Results 11 to 20 of about 3,493 (184)
Cold Spring Harbor Perspectives in Biology, 2004 Thrombospondins are evolutionarily conserved, calcium-binding glycoproteins that undergo transient or longer-term interactions with other extracellular matrix components. They share properties with other matrix molecules, cytokines, adaptor proteins, and chaperones, modulate the organization of collagen fibrils, and bind and localize an array of growth
Adams, JC, Lawler, J
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Invoking the power of thrombospondins: Regulation of thrombospondins expression
Matrix Biology, 2014 Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of physiological and pathological processes. With the growing understanding of the importance of these matricellular proteins, the need to understand the mechanisms of regulation of their expression and potential approaches to modulate their levels is also increasing.
Olga Stenina-Adognravi
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Current Opinion in Lipidology, 2013 Thrombospondins (TSPs) are secreted extracellular matrix (ECM) proteins from TSP family, which consists of five homologous members. They share a complex domain structure and have numerous binding partners in ECM and multiple cell surface receptors. Information that has emerged over the past decade identifies TSPs as important mediators of cellular ...
Olga Stenina-Adognravi
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BMC Evolutionary Biology, 2006 Background Thrombospondins (TSPs) are evolutionarily-conserved, extracellular, calcium-binding glycoproteins with important roles in cell-extracellular matrix interactions, angiogenesis, synaptogenesis and connective tissue organisation.
Adams Josephine C +3 more
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Characterisation of Drosophila Thrombospondin Defines an Early Origin of Pentameric Thrombospondins
Journal of Molecular Biology, 2003 Thrombospondins (TSPs) are multidomain oligomers that have complex roles in cell interactions and tissue organisation. The five vertebrate TSPs comprise two subgroups, A and B, that are assembled as trimers or pentamers, respectively. An invertebrate TSP was recently discovered in Drosophila melanogaster, but there is no knowledge of the ...
Josephine C, Adams +6 more
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Clinical and Translational Medicine, 2021 Background Improved understanding of the interconnectedness of structural remodeling processes in atrial fibrillation (AF) in patients could identify targets for future therapies.
Nicoline W. E. van den Berg +13 more
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THBS1 (thrombospondin-1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020 Thrombospondins are encoded in vertebrates by a family of 5 THBS genes. THBS1 is infrequently mutated in most cancers, but its expression is positively regulated by several tumor suppressor genes and negatively regulated by activated oncogenes and promoter hypermethylation. Consequently, thrombospondin-1 expression is frequently lost during oncogenesis
Isenberg, Jeffrey S, Roberts, David D
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Role of A Single Nucleotide Polymorphism in Thrombospondine 4 Gene in Premature Myocardial Infarction among Population of Southern Iran [PDF]
ARYA Atherosclerosis, 2023 Background: Coronary Artery Diseases (CAD) are the leading cause of Myocardial Infarction (MI). However, their underlying etiology can be found in the interplay between environmental and genetic factors.
Nazanin Farahbakhsh +5 more
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