Results 41 to 50 of about 3,493 (184)
Modulation of the extracellular matrix patterning of thrombospondins by actin dynamics and thrombospondin oligomer state [PDF]
, 2015 Thrombospondins (TSPs) are evolutionarily-conserved, secreted glycoproteins that interact with cell surfaces and extracellular matrix (ECM) and have complex roles in cell interactions.
Christofidou, Elena +4 more
core +1 more source
Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth
Pain and Therapy, 2020 Introduction Recent years have seen a dramatic escalation of off-label prescribing for gabapentin and pregabalin (gabapentinoids) owing in part to generic versions of each being released over the past two decades, but also in part as a response to ...
Heath McAnally, Udo Bonnet, Alan D. Kaye
doaj +1 more source
Inter-Molecular Interactions Of Thrombospondins Drive Their Accumulation In Extracellular Matrix
, 2015 Thrombospondins participate in many aspects of tissue organisation in adult tissue homeostasis, and their dysregulation contributes to pathological processes such as fibrosis and tumour progression. The incorporation of thrombospondins into extracellular
Elena D. Christofidou (7633637) +9 more
core +1 more source
A new look at the etiopathogenesis ofadolescent idiopathic scoliosis
Pediatria i Medycyna Rodzinna, 2016 Adolescent idiopathic scoliosis is the most common form of spinal deformity in children. The aetiology of the condition has not been elucidated. Currently, the multifactorial theory seems to be the most probable.
Maciej Brzęczek +2 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC).
Yu Shi +10 more
doaj +1 more source
Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus. [PDF]
PLoS ONE, 2013 The lithium-pilocarpine model of epilepsy reproduces in rodents several features of human temporal lobe epilepsy, by inducing an acute status epilepticus (SE) followed by a latency period.
Alicia Raquel Rossi +4 more
doaj +1 more source
Biophysical Characterization of the Signature Domains of Thrombospondin-4 and Thrombospondin-2 [PDF]
Journal of Biological Chemistry, 2005 The signature domain of thrombospondins consists of tandem epidermal growth factor-like modules, 13 calcium-binding repeats, and a lectin-like module. Although very similar, the signature domains of thrombospondin-1 and -2 differ in several potentially important ways from the domains of thrombospondin-3, -4, and -5.
Tina M, Misenheimer, Deane F, Mosher
openaire +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: Fibroblast growth factor receptor 2 (FGFR2) has attracted considerable interest as a therapeutic target in gastric cancer (GC). There is growing evidence to suggest that the bioavailability of the potent pro-tumor function of FGFR2 is ...
Tingting Huang +9 more
doaj +1 more source
Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review)
International Journal of Molecular Medicine, 2020 Thrombospondin (TSP)‑1 and TSP‑2 are matricellular proteins in the extracellular matrix (ECM), which serve a significant role in the pathological processes of various cardiovascular diseases (CVDs). The multiple effects of TSP‑1 and TSP‑2 are due to their ability to interact with various ligands, such as structural components of the ECM, cytokines ...
Zhang, Kaijie +4 more
openaire +3 more sources
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages
Cellular Physiology and Biochemistry, 2018 Background/Aims: ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions.
Jianjun Chen +8 more
doaj +1 more source