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The mechanobiology of extracellular matrix: a focus on thrombospondins [PDF]

Cell Communication and Signaling
Mechanosensitive thrombospondins (TSPs), a class of extracellular matrix (ECM) glycoproteins, have garnered increasing attention for their pivotal roles in transducing mechanical cues into biochemical signals during tissue adaptation and disease ...
Ying Zhao, Ting Lei, Xin Ge, Liumeizi Fan, Yinbin He, Zhou Yu, Sheng Hu   +6 more
doaj   +2 more sources

Age and Sex Impact the Role of Thrombospondin‐2 and Thrombospondin‐5 in Response to Hindlimb Ischemia [PDF]

FASEB BioAdvances
Peripheral arterial disease progression to critical limb ischemia remains a significant burden in the aged, necessitating revascularization. Therapies to enhance neovascularization, such as angiogenesis or arteriogenesis, may provide an option for ...
Ashley A. Peters, Melissa Rangel, Corinne Bunn, Xuerong Wang, Irene Helenowski, Kristopher G. Maier, Vivian Gahtan   +6 more
doaj   +2 more sources

Integrating bulk RNA-seq and scRNA-seq analyses revealed the function and clinical value of thrombospondins in colon cancer [PDF]

Computational and Structural Biotechnology Journal
Background: Acting as mediators in cell-matrix and cell-cell communication, matricellular proteins play a crucial role in cancer progression. Thrombospondins (TSPs), a type of matricellular glycoproteins, are key regulators in cancer biology with ...
Jing Li, Ying Tang, Fei Long, Luyao Tian, Ao Tang, LiHui Ding, Juan Chen, Mingwei Liu   +7 more
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Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model [PDF]

BMC Musculoskeletal Disorders
Background Osteoarthritis (OA) is a common cause of disability around the world, but the pathophysiology is still poorly understood. The study sought to investigate the effects of umbilical cord mesenchymal stem cells (UC-MSCs) injection in OA, with a ...
Yanqun Li, Qipeng Han, Shayan Chen, Wenlong Huang, Yanqing Chen, Zhihuang Wu, Fengming Tan, Muyun Liu, Jiangying Zou   +8 more
doaj   +2 more sources

The Significance of Selected Collagens and Their Connection with Relevant Extracellular Matrix Proteins in Bovine Early-Mid-Pregnancy and Parturition with and Without Retained Foetal Membranes [PDF]

Biomolecules
Appropriate placental structure and function assure foetal development, delivery of nutrients, and removal of waste. Collagens, as structural proteins, are crucial for the maintenance of placental growth and function.
Jacek Wawrzykowski, Monika Jamioł, Marta Kankofer   +2 more
doaj   +2 more sources

Structure, evolution and expression of zebrafish cartilage oligomeric matrix protein (COMP, TSP5). CRISPR-Cas mutants show a dominant phenotype in myosepta

Frontiers in Endocrinology, 2022
COMP (Cartilage Oligomeric Matrix Protein), also named thrombospondin-5, is a member of the thrombospondin family of extracellular matrix proteins. It is of clinical relevance, as in humans mutations in COMP lead to chondrodysplasias.
Helena Fabiana Forte-Gomez, Roberta Gioia, Francesca Tonelli, Birgit Kobbe, Peter Koch, Wilhelm Bloch, Mats Paulsson, Frank Zaucke, Antonella Forlino, Raimund Wagener   +9 more
doaj   +1 more source

Different expression pattern of thrombospondin gene in the presence and absence of β-glucan fed Penaeus monodon challenged with white spot syndrome virus

Fish and Shellfish Immunology Reports, 2021
Thrombospondins (TSPs) are extracellular, calcium-binding glycoproteins that play an essential role in cell homeostasis and development, wound-healing, angiogenesis, connective tissue organization, immune response etc.
Moger Rajeish, Mundanda Muthappa Dechamma, Madhu K. Mani, Praveen Rai, Iddya Karunasagar, Peter Bossier, Indrani Karunasagar, Biswajit Maiti   +7 more
doaj   +1 more source

The Calcium Channel α2δ1 Subunit: Interactional Targets in Primary Sensory Neurons and Role in Neuropathic Pain

Frontiers in Cellular Neuroscience, 2021
Neuropathic pain is mainly triggered after nerve injury and associated with plasticity of the nociceptive pathway in primary sensory neurons. Currently, the treatment remains a challenge. In order to identify specific therapeutic targets, it is necessary
Wenqiang Cui, Hongyun Wu, Xiaowen Yu, Ting Song, Xiangqing Xu, Fei Xu   +5 more
doaj   +1 more source

Endothelial Cell Behavior Is Determined by Receptor Clustering Induced by Thrombospondin-1

Frontiers in Cell and Developmental Biology, 2021
The thrombospondins (TSPs) are a family of multimeric extracellular matrix proteins that dynamically regulate cellular behavior and response to stimuli.
Verônica Morandi, Jim Petrik, Jack Lawler   +2 more
doaj   +1 more source

A thrombospondin in the anthozoan Nematostella vectensis is associated with the nervous system and upregulated during regeneration

Biology Open, 2012
Summary Thrombospondins are multimeric extracellular matrix glycoproteins that play important roles in development, synaptogenesis and wound healing in mammals.
Richard P. Tucker, John F. Hess, Qizhi Gong, Katrina Garvey, Bradley Shibata, Josephine C. Adams   +5 more
doaj   +1 more source