Results 151 to 160 of about 286,478 (209)

Targeting the COX1/2-Driven thromboxane A2 pathway suppresses Barrett's esophagus and esophageal adenocarcinoma development. [PDF]

EBioMedicine, 2019
Zhang T, Wang Q, Ma WY, Wang K, Chang X, Johnson ML, Bai R, Bode AM, Foster NR, Falk GW, Limburg PJ, Iyer PG, Dong Z.   +12 more
europepmc   +1 more source

Thromboxane A₂ Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14-3-3γ/StAR Signaling. [PDF]

Adv Sci (Weinh)
Yan S, Wang Y, Wang B, Zuo S, Yu Y.
europepmc   +1 more source

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. [PDF]

J Clin Invest, 2019
Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ.   +13 more
europepmc   +1 more source

[Determination of three metabolites of thromboxane A₂ and 8-iso-prostaglandin F_2α in urine by ultra performance liquid chromatography-tandem mass spectrometry]. [PDF]

Se Pu
Liu SJ, Zhao FR, Zhang YL, Sun XY, Zhang MM, Hou K, Cao YF.   +6 more
europepmc   +1 more source

Effects of thromboxane A2 on lymphocyte proliferation

Cellular Immunology, 1985
The main cyclooxygenase-dependent arachidonic acid derivatives produced by monocytes and macrophages have been shown to be thromboxane A2 and prostaglandin E2. The immunomodulatory effects of thromboxane A2 were examined using a specific thromboxane synthase inhibitor (dazoxiben), a thromboxane A2 analog (U46619), and a thromboxane A2 receptor blocker (
J L, Ceuppens, S, Vertessen, H, Deckmyn, J, Vermylen   +3 more
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Anti-thromboxane A2 actions of pinane thromboxane A2 derivatives

Prostaglandins, Leukotrienes and Medicine, 1982
Six pinane-thromboxane A2 analogs have been synthesized and tested for their ability to antagonize carbocyclic thromboxane A2 (CTA2) induced coronary vasoconstriction and prostaglandin endoperoxide analog induced platelet aggregation. Two of the derivatives, 5C-15S BPTA2 and 5T-15S BPTA2 and 5T-15S BPTA2 (1 microM) showed 76 +/- 3 and 72 +/- 9 percent ...
D M, Roth, A M, Lefer, J B, Smith, K C, Nicolaou   +3 more
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Role of Thromboxane A2

1985
When platelets are stimulated to aggregate and secrete by a sub-maximal concentration of an agonist, the platelets on the outside of an aggregate appear more degranulated than those on the inside (1) (fig. 1). In the example shown, aggregation of rabbit platelet-rich plasma (PRP) was induced by a sub-maximal concentration of collagen.
J, Ambler, J, Birch, E D, Maguire, R B, Wallis   +3 more
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Analogues of thromboxane A2

Tetrahedron, 1995
Abstract A synthesis of 7[3(3 R -hydroxy-3-cyclohexyl-l-propyl)-7-oxa-l S ,2 S ,3 S ,4- R -bicyclo[2.2.1]-heptan-2-yl-5Z-heptenoic acid 1, an ω-chain saturated analogue of Thromboxane A 2 is described. The relative and the absolute configurations of the intermediates and the target compound were determined by 2D FT NMR methods.
Anne Paju, Alo Soone, Tonis Pehk, Margus Lopp   +3 more
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On the structure of thromboxane A2

Tetrahedron Letters, 1984
Abstract The reactions of the 2-alkoxyoxetane 5 with sodium azide and methanol yield the α-azidoether 7 and the dimethyl acetal 8, respectively, paralleling reactions reported for TXA 2 . The hydrolysis of 5 reported by Bruice to involve general acid catalysis proceeds at a rate similar to that reported for TXA 2 .
Josef Fried, Ziqing Zhou, Chen Chien-Kuang   +2 more
openaire   +1 more source