Results 161 to 170 of about 286,478 (209)

Carbocyclic thromboxane A2: Aggrevation of myocardial ischemia by a new synthetic thromboxane A2 analog

Prostaglandins, 1981
In vitro experiments indicate that thromboxane A2 (TA2) is a potent platelet aggregator and vascular constrictor. However, it is unclear what roles these specific actions may contribute in the pathophysiology of myocardial ischemia. Carbocyclic thromboxane A2 (CTA2), a TA2 analog, constrict isolated perfused cat coronary arteries, but does not ...
E F, Smith, A M, Lefer, D, Aharony, J B, Smith, R L, Magolda, D, Claremon, K C, Nicolaou   +6 more
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Thromboxane A2 in acute myocardial infarction

The American Journal of Cardiology, 1982
We evaluated the presence of thromboxane B2, the stable metabolite of thromboxane A2, early in the course of acute myocardial infarction (AMI) in both animal and patient studies. In an open-chest model, the left anterior descending artery (LAD) was isolated and the great cardiac vein was cannulated in nine dogs.
P, Walinsky, J B, Smith, A M, Lefer, M, Lebenthal, P, Urban, A, Greenspon, S, Goldberg   +6 more
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Novel prostanoid thromboxane A2 agonists

Prostaglandins, 1995
The chemistry and biology of novel TXA2(TP)-receptor agonists based on the prostanoid skeleton is described and structure-activity-relationships are discussed. One compound,(5Z,13E), (9R,15R)-9-fluoro-15-hydroxy-16-phenoxy-17,18,19,20-tetranor- 5,13-prostadienoic acid (33), was identified which is 10 times more potent than the standard TP-receptor ...
K D, Joachim, U, Klar, A, Pletsch, H, Rehwinkel, W, Skuballa   +4 more
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Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion

Journal of Molecular Medicine, 2010
Thromboxane A(2) (TXA(2)) is a potent prothrombotic and immune modulating lipid mediator, which is implicated in cardiovascular diseases, in particular, atherosclerotic lesion development and thrombogenicity. Here, we tested the hypothesis that thromboxane synthase (TXAS), the obligate enzyme required to synthesize TXA(2), is expressed within the human
Anders, Gabrielsen, Hong, Qiu, Magnus, Bäck, Mats, Hamberg, Anne-Louise, Hemdahl, Hanna, Agardh, Lasse, Folkersen, Jesper, Swedenborg, Ulf, Hedin, Gabrielle, Paulsson-Berne, Jesper Z, Haeggström, Göran K, Hansson   +11 more
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Thromboxane A2 Inhibition

American Journal of Respiratory Medicine, 2002
Bronchial asthma is a disease defined by reversible airway obstruction, bronchial hyperresponsiveness and inflammation. In addition to histamine and acetylcholine, recent studies have emphasized the role of arachidonic acid metabolites (leukotrienes, prostaglandins and thromboxane A(2)) in the pathogenesis of asthma.
Dogné, Jean-Michel, de Leval, Xavier, Benoît, Patricia, Delarge, Jacques, Masereel, Bernard   +4 more
openaire   +3 more sources

Cyclosporine A nephrotoxicity — the role of thromboxane A2

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 1988
Cyclosporinc A (CyA) is now established as the immunosuppressant of choice in human organ transplantation since it improves graft survival and is not associated with myelosuppression. It is also used as a prophylaxis against grafts versus host disease in bone marrow transplant recipients.
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Synthesis of thromboxane A2 analog, dl-(9,11)-methano-(11,12)-amino thromboxane A2

Tetrahedron Letters, 1982
Abstract A synthesis of nitrogen containing thromboxane, A 2 analog, dl -(9,11)-methano-(11,12)-amino thromboxane A 2 ( 1 ) is described.
Shunji Kosuge, Masaki Hayashi, Nobuyuki Hamanaka   +2 more
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The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor

Coronary Artery Disease, 1994
The role of thromboxane A2 (TxA2) in unstable angina has not yet been defined. TxA2 receptor antagonists may be of value in studying this role.To investigate whether TxA2 has a pathogenetic effect on the occurrence of myocardial ischemia and from what source TxA2 originates, we studied TxA2 formation by unstimulated monocytes from patients with ...
Gian Gastone Neri Serneri, Gian Franco Gensini, Loredana Poggesi, Pietro Amedeo Modesti, Carlo Rostagno, Maria Boddi, Anna Maria Gori, Francesca Martini, Aldo leri, Massimo Margheri, Rosanna Abbate   +10 more
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Thromboxane A2 receptors

Journal of Lipid Mediators and Cell Signalling, 1995
P V, Halushka, C J, Allan, K L, Davis-Bruno   +2 more
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Thromboxane A2 and Prostacyclin in Tumorigenesis

1988
A tumour cell arises from a normal cell by changes in the processes of cell regulation, growth and differentiation. The complexity of such regulatory mechanisms, however, makes it difficult to understand the pathogenesis of malignant growth.
V. Ullrich, M. Hecker, R. Nüsing, T. Rosenbach   +3 more
openaire   +1 more source