Results 51 to 60 of about 286,478 (209)

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

Thromboxane A2 Antagonist : Discovery of Seratrodast

YAKUGAKU ZASSHI, 1999
We were interested in RCS (rabbit aorta contracting substance) and SRS-A (slow reacting substance of anaphylaxis) and their involvement in human bronchial asthma. When we started our anti-asthmatic drug research in the 1970's. We synthesized a lot of chemical compounds and eventually discovered that AA-861 inhibited the generation of SRS-A from the ...
S, Terao, M, Shiraishi, T, Matsumoto, Y, Ashida   +3 more
openaire   +3 more sources

Role of plasma neuropeptide Y in acute myocardial infarction: a case-control study

BMC Cardiovascular Disorders
Background As neuropeptide Y is associated with endothelial dysfunction, this study explored the relationship between neuropeptide Y and acute myocardial infarction. Methods We included 128 acute myocardial infarction cases and 62 controls.
Yan-li Zheng, Hui-li Lin, Yue-ting Li, Mei-mei Li, Jing-ru Du, Wan-da Wang, Yao-guo Wang, Yin-lian Cai   +7 more
doaj   +1 more source

Urinary leukotriene E4 and 11-dehydro-thromboxane B2 excretion in children with bronchial asthma

Allergology International, 2004
Background: Cysteinyl leukotrienes (CysLTs) and thromboxane (TX) A2 have been implicated in the pathogenesis of bronchial asthma. Urinary leukotriene E4 (LTE4) and 11-dehydro-TXB2 (11 DTXB2) levels are often used to assess the production of CysLTs and ...
Kaori Yoshikawa, Eiko Matsui, Ryosuke Inoue, Hideo Kaneko, Takahide Teramoto, Minako Aoki, Kimiko Kasahara, Shinji Shinoda, Osamu Fukutomi, Naomi Kondo   +9 more
doaj   +1 more source

Inverse agonism of SQ 29,548 and Ramatroban on Thromboxane A2 receptor. [PDF]

PLoS ONE, 2014
G protein-coupled receptors (GPCRs) show some level of basal activity even in the absence of an agonist, a phenomenon referred to as constitutive activity.
Raja Chakraborty, Rajinder P Bhullar, Shyamala Dakshinamurti, John Hwa, Prashen Chelikani   +4 more
doaj   +1 more source

ALOX15 links lipid metabolism to receptor trafficking in platelet activation

The FEBS Journal, EarlyView.
This schematic summarizes known and newly identified mechanisms of thrombin‐mediated platelet activation. In addition to classical thrombin‐induced PAR4 signaling pathways, thrombin activates an ALOX15–HETE–PKCθ–NMT1 signaling cascade that promotes protein myristoylation, facilitates receptor trafficking, and enhances PAR4 surface expression on ...
Yosef Eshetie Amare, Sharad Saxena, Serena Zacchigna   +2 more
wiley   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source

The Role of Thromboxane A2 in Reperfusion Injury

Experimental Biology and Medicine, 1988
Thromboxane A2 (TXA2) receptor antagonists can limit infarct size in models of coronary occlusion and reperfusion, but it was unknown if these compounds can mitigate reperfusion injury. Anesthetized open chest dogs were subjected to left circumflex coronary (LCX) occlusion for 90 min.
G J, Grover, P G, Sleph, C, Parham
openaire   +2 more sources

Testing for Non‐Severe Heritable Platelet Function Disorders

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Heritable platelet function disorders (HPFD) are a diverse group of bleeding disorders characterised by a primary qualitative defect in platelet function rather than platelet number. HPFD may be broadly categorised according to the severity of bleeding, with Glanzmann thrombasthenia and Bernard Soulier syndrome classically considered severe ...
Kate Burley, Naomi Cornish, Maria Molina Carretero, Sarah K. Westbury   +3 more
wiley   +1 more source