Results 61 to 70 of about 286,478 (209)
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
An aspirin a day keeps cancer at bay
BJC ReportsIt has long been hypothesised that aspirin prevents cancer deaths by preventing metastasis. A recent study demonstrates this to be mediated through inhibition of Thromboxane A2 (TXA2) leading to reversal of suppression of T cell immunity.
Mangesh A. Thorat
doaj +1 more source
Investigation of a Thromboxane A2 Receptor–Based Vaccine for Managing Thrombogenesis
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 Background Despite the well‐established role for the thromboxane A2 receptor (TPR) in the development of thrombotic disorders, none of the antagonists developed to date has been approved for clinical use.
Fatima Z. Alshbool +4 more
doaj +1 more source
On the mechanism of prostacyclin and thromboxane A2 biosynthesis
Journal of Biological Chemistry, 1989 The present research describes studies which address the mechanism of prostacyclin (PGI2) and thromboxane A2 (TXA2) biosynthesis. In addition to prostaglandin H1 (PGH1), PGG2, PGH2, and PGH3, also 8-iso-PGH2, 13(S)-hydroxy-PGH2, and 15-keto-PGH2 were applied to determine the substrate specificities and kinetics of prostacyclin and thromboxane synthase ...
M, Hecker, V, Ullrich
openaire +2 more sources
Experimental Physiology, EarlyView.Abstract Vascular endothelial growth factor receptor (VEGFR) inhibitors are effective antiangiogenic agents used in cancer therapy. However, they are associated with cardiovascular disease, including hypertension and vascular dysfunction. The molecular mechanisms underlying these cardiovascular toxicities are unclear, but oxidative stress might be ...
Karla B. Neves +3 more
wiley +1 more source
Investigation of thromboxane A2 synthase knockout mice
, 2007 Thromboxane A2合成酶(TXA2 synthase)所生產的TXA2具有引發血小板凝集、血管收縮及調節腎臟等功能，且在包含心肌梗塞、中風、氣喘及許多的腎臟疾病發生的過程中均扮演重要的角色。除了參與眾所周知的凝血與血栓形成外，TXA2被認為可能參與血小板生成及淋巴球的分化。為了進一步了解其生理功能，本論文以基因轉殖的方式製作TXA2合成酶基因剔除(TXAS-/-)小鼠模式。分析結果發現TXAS-/-小鼠具有正常的骨髓巨核細胞，其胸腺及脾臟的淋巴球數量也正常。但其出血時間異常且以花生四烯酸 ...
Yu, I-Shing, 游益興
core
iScienceSummary: Thromboxane prostanoid (TP) receptors play an important role in platelet activation and hemostasis. Although TP receptors undergo palmitoylation within the platelet proteome, its impact on platelet functions and the underlying mechanisms have ...
Suresh Govatati +3 more
doaj +1 more source
Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice
Journal of Xenobiotics, 2011 Prostanoids are lipid compounds that mediate a variety of physiological and pathological functions in almost all body tissues and organs. Thromboxane (TX) A2 is a powerful inducer of platelet aggregation and vasoconstriction and it has ulcerogenic ...
Ivan Ćavar +3 more
doaj +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Journal of Lipid Research, 2001 Lipid hydroperoxides have been reported to regulate cell function and eicosanoid formation. The aim of the present study was to determine the effect of 12(S)-hydroperoxy-eicosatetraenoic acid [12(S)-HPETE], the platelet 12-lipoxygenase-derived ...
Catherine Calzada +4 more
doaj +1 more source