Results 71 to 80 of about 1,541,967 (286)

Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies

open access: yesmAbs
The correct pairing of cognate heavy and light chains is critical to the efficient manufacturing of IgG-like bispecific antibodies (bsAbs) from a single host cell.
Kyle A. Barlow   +13 more
doaj   +1 more source

De novo genome assembly resolving repetitive structures enables genomic analysis of 35 European Mycoplasmopsis bovis strains

open access: yesBMC Genomics, 2023
Mycoplasmopsis (M.) bovis, the agent of mastitis, pneumonia, and arthritis in cattle, harbors a small genome of approximately 1 Mbp. Combining data from Illumina and Nanopore technologies, we sequenced and assembled the genomes of 35 European strains and
Sandra Triebel   +7 more
doaj   +1 more source

High-Throughput Phenomics

open access: yes, 2015
Standard protocols are available in order to apply Phenotype MicroArray (PM) technology to characterize different groups of microorganisms. Nevertheless, there is the need to pay attention to several crucial steps in order to obtain high-quality and reproducible data from PM, such as the choice of the Dye mix, the type and concentration of the carbon ...
Carlo, Viti   +4 more
openaire   +3 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Uplink Downlink Rate Balancing and throughput scaling in FDD Massive MIMO Systems

open access: yes, 2015
In this work we extend the concept of uplink-downlink rate balancing to frequency division duplex (FDD) massive MIMO systems. We consider a base station with large number antennas serving many single antenna users.
Bergel, Itsik   +2 more
core   +1 more source

A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor

open access: yesCancer Cell International, 2019
Background The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs in the development of colorectal ...
Qingmei Wang   +8 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Network Utility Maximization under Maximum Delay Constraints and Throughput Requirements

open access: yes, 2018
We consider the problem of maximizing aggregate user utilities over a multi-hop network, subject to link capacity constraints, maximum end-to-end delay constraints, and user throughput requirements.
Chen, Minghua, Liu, Qingyu, Zeng, Haibo
core   +1 more source

High-throughput Technology and High-throughput Factory

open access: yesNihon Kessho Gakkaishi, 2003
Structural Genomics has launched over the world including National Project of Protein Structural and Functional Analysis in Japan in a post-genomic era. It remains many bottlenecks to determine the protein structures with SR protein crystallography based on full-genome sequence information in high throughput manner.
Masashi MIYANO   +2 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

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