Results 61 to 70 of about 1,560,074 (286)

Defining the elusive oncogenic role of the methyltransferase TMT1B

Frontiers in Oncology, 2023
Methyltransferases are enzymes fundamental to a wide range of normal biological activities that can become dysregulated during oncogenesis. For instance, the recent description of the methyltransferase-like (METTL) family of enzymes, has demonstrated the
Sarah E. Denford, Brian T. Wilhelm, Brian T. Wilhelm   +2 more
doaj   +1 more source

Throughput Analysis of Primary and Secondary Networks in a Shared IEEE 802.11 System

, 2012
In this paper, we analyze the coexistence of a primary and a secondary (cognitive) network when both networks use the IEEE 802.11 based distributed coordination function for medium access control.
Ayyagari, Arun, Kumar, Santhosh, Murthy, Chandra R., Shende, Nirmal   +3 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

RIBAP: a comprehensive bacterial core genome annotation pipeline for pangenome calculation beyond the species level

Genome Biology
Microbial pangenome analysis identifies present or absent genes in prokaryotic genomes. However, current tools are limited when analyzing species with higher sequence diversity or higher taxonomic orders such as genera or families.
Kevin Lamkiewicz, Lisa-Marie Barf, Konrad Sachse, Martin Hölzer   +3 more
doaj   +1 more source

Effects of Transport Delays of Manual Control System Performance [PDF]

, 1984
Throughput or transport delays in manual control systems can cause degraded performance and lead to potentially unstable operation. With the expanding use of digital processors, throughput delays can occur in manual control systems in a variety of ways ...
Allen, R. W., Dimarco, R. J.
core   +1 more source

Uplink Downlink Rate Balancing and throughput scaling in FDD Massive MIMO Systems

, 2015
In this work we extend the concept of uplink-downlink rate balancing to frequency division duplex (FDD) massive MIMO systems. We consider a base station with large number antennas serving many single antenna users.
Bergel, Itsik, Perets, Yona, Shamai, Shlomo   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Design of orthogonal constant domain interfaces to aid proper heavy/light chain pairing of bispecific antibodies

mAbs
The correct pairing of cognate heavy and light chains is critical to the efficient manufacturing of IgG-like bispecific antibodies (bsAbs) from a single host cell.
Kyle A. Barlow, Michael B. Battles, Michael E. Brown, Kaleigh Canfield, Xiaojun Lu, Heather Lynaugh, Morgan Morrill, C. Garrett Rappazzo, Saira P. Reyes, Chanita Sandberg, Beth Sharkey, Christin Strong, Jingfu Zhao, Arvind Sivasubramanian   +13 more
doaj   +1 more source

Throughput of ADSL modems [PDF]

, 1999
This paper considers the throughput of ADSL (Asymmetric Digital Subscriber Line) modems, used for high-speed data transmission over relatively unreliable connections, e.g. copper telephone wires.
Broersma, Haitze J., Bruin, N., Hurink, Johann L., Meester, L.E., op de Beek, S.S., Westhuis, J., Westhuis, J.H.   +6 more
core   +2 more sources

High-throughput Technology and High-throughput Factory

Nihon Kessho Gakkaishi, 2003
Structural Genomics has launched over the world including National Project of Protein Structural and Functional Analysis in Japan in a post-genomic era. It remains many bottlenecks to determine the protein structures with SR protein crystallography based on full-genome sequence information in high throughput manner.
MIYANO, Masashi, SUGAHARA, Mitsuaki, YAMAMOTO, Masaki   +2 more
openaire   +2 more sources