Results 241 to 250 of about 5,098,470 (266)

Notch activation in thymic epithelial cells induces development of thymic microenvironments

Molecular Immunology, 2009
The development and maintenance of thymic microenvironments depends on sustained crosstalk signals derived from developing thymocytes. However, the molecular basis for the initial phase in the lymphoid dependent development of thymic epithelial cells (TECs) remains unclear.
Kyoko, Masuda, Wilfred T V, Germeraad, Rumi, Satoh, Manami, Itoi, Tomokatsu, Ikawa, Nagahiro, Minato, Yoshimoto, Katsura, Willem, van Ewijk, Hiroshi, Kawamoto   +8 more
openaire   +2 more sources

Characterization of human thymic epithelial cell surface antigens: Phenotypic similarity of thymic epithelial cells to epidermal keratinocytes

Journal of Clinical Immunology, 1995
Cellular interactions between developing thymocytes and cells of the thymic microenvironment are necessary for maturation of thymocytes into mature T cells. While much is known about the molecules on developing T cells that mediate these interactions, little is known about the surface molecules of human thymic epithelial (TE) cells.
D D, Patel, L P, Whichard, G, Radcliff, S M, Denning, B F, Haynes   +4 more
openaire   +2 more sources

The adaptive phenotype of cortical thymic epithelial cells

European Journal of Immunology, 2009
AbstractEpithelial cells in the thymus are required for positive and negative selection of developing thymocytes. Although medullary epithelial cells play a major role in negative selection owing to their facility of expressing peripheral self‐antigens, the adaptive features of cortical epithelial cells are largely unknown. A paper in this issue of the
openaire   +3 more sources

Development and Function of Cortical Thymic Epithelial Cells

2013
The thymic cortex provides a microenvironment that supports the generation and T cell antigen receptor (TCR)-mediated selection of CD4(+)CD8(+)TCRαβ(+) thymocytes. Cortical thymic epithelial cells (cTECs) are the essential component that forms the architecture of the thymic cortex and induces the generation as well as the selection of newly generated T
Kensuke, Takada, Izumi, Ohigashi, Michiyuki, Kasai, Hiroshi, Nakase, Yousuke, Takahama   +4 more
openaire   +2 more sources

Transcriptional and epigenetic regulation in thymic epithelial cells*

Immunological Reviews, 2022
Avinash Bhandoola
exaly  

Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus

Journal of Allergy and Clinical Immunology, 2022
Mohsen Khosravi Maharlooei, Megan Sykes, Amanda Ruiz   +2 more
exaly  

Thymic Epithelial Cell

2020
openaire   +1 more source

Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development

Frontiers in Immunology, 2020
Yong Zhao, Hongxia Wang, Yurong Qiu
exaly  

THYMIC EPITHELIAL CELL CONTAINS ACETYLCHOLINE RECEPTOR

The Lancet, 1977
E K, Engel, J L, Trotter, D E, McFarlin, C L, McIntosh   +3 more
openaire   +2 more sources

Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation

Biomaterials, 2017
Ann Chidgey, John A M Ramshaw, Kahlia Wong   +2 more
exaly