Results 81 to 90 of about 58,824 (241)

Age-Associated Decline in Thymic B Cell Expression of Aire and Aire-Dependent Self-Antigens

Cell Reports, 2018
Summary: Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood.
Sergio Cepeda, Carolina Cantu, Stephanie Orozco, Yangming Xiao, Zoe Brown, Manpreet K. Semwal, Thomas Venables, Mark S. Anderson, Ann V. Griffith   +8 more
doaj   +1 more source

Retinoic acid as a modulator of T cell immunity [PDF]

, 2016
Indexación: Scopus. DOAJ.Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual system,
Bono, M.R., Fernandez, D., Flores-Santibañez, F, Rosemblatt, M., Sauma, D., Tejon, G.   +5 more
core   +1 more source

Regenerative capacity of adult cortical thymic epithelial cells [PDF]

Proceedings of the National Academy of Sciences, 2012
Involution of the thymus is accompanied by a decline in the number of thymic epithelial cells (TECs) and a severely restricted peripheral repertoire of T-cell specificities. TECs are essential for T-cell differentiation; they originate from a bipotent progenitor that gives rise to cells of cortical (cTEC) and medullary (mTEC) phenotypes ...
Rode, Immanuel, Boehm, Thomas
openaire   +4 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma [PDF]

, 2008
Thymic epithelial cells can produce many kinds of cytokines, and interleukin (IL)-6-producing thymic carcinoma cases have been reported. However, a cytokine-producing human thymic tumor cell line has not previously been established.
59698, 59699, 59700, 59701, 59702, 59703, 59704, 59705, IMAMURA, Yoshiaki, INAI, Kunihiko, NAIKI, Hironobu, NORIKI, Sakon, OKADA, Hiromi, TAKAGI, Kazutaka, TAKIMOTO, Nobuo, UEDA, Takanori   +15 more
core   +1 more source

Understanding the Thymic Microenvironment: the Cellular and Molecular Basis of T Cell Development

Central Asian Journal of Medical Sciences, 2016
Objectives: The thymus is a primary lymphoid organ that provides specialized microenvironment for T cell development. A variety of thymic stromal cells form the thymic tissue architecture and critically regulate the development and repertoire selection ...
Takeshi Nitta
doaj   +1 more source

p73 Is Expressed in Human Thymic Epithelial Cells [PDF]

Journal of Histochemistry & Cytochemistry, 2002
The thymus is a heterogeneous immune organ in which immature T-cells develop and eventually specialize to make certain immune responses of their own. Among various types of stromal cells in the thymus, thymic epithelial cells (TECs) have a crucially important function for presenting self-antigens and secreting cytokines to thymocytes for their ...
Shingo, Ichimiya, Takashi, Kojima, Hiroyuki, Momota, Nobuhiko, Kondo, Toshinori, Ozaki, Akira, Nakagawara, María Luisa, Toribio, Masakatsu, Imamura, Noriyuki, Sato   +8 more
openaire   +2 more sources

Successful treatment of eosinophilic esophagitis with upadacitinib prescribed for atopic dermatitis

JPGN Reports, EarlyView.
Abstract We describe a pediatric patient treated with upadacitinib for atopic dermatitis (AD) who subsequently achieved sustained clinical and histologic remission of eosinophilic esophagitis (EoE). Upadacitinib is an oral small molecule selective Janus kinase 1 inhibitor that inhibits janus kinase‐signal transduction and activation of transcription ...
Nathalie Nguyen, Maureen Bauer
wiley   +1 more source

Long-term human hematopoiesis in the SCID-hu mouse. [PDF]

, 1990
Coimplantation of small fragments of human fetal thymus and fetal liver into immunodeficient SCID mice resulted in the formation of a unique structure (Thy/Liv).
Kaneshima, H, McCune, Joseph, Namikawa, R, Weilbaecher, K, Yee, E   +4 more
core  

Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype. [PDF]

, 2014
To access publisher's full text version of this article click on the hyperlink at the bottom of the pageDown syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and ...
Annerén, Göran, Berglund, Martin, Ekwall, Olov, Gudmundsdottir, Judith, Gustafsson, Jan, Kämpe, Olle, Lindgren, Susanne, Lundberg, Vanja, Sandström, Kerstin, Skogberg, Gabriel, Sunnegårdh, Jan, Telemo, Esbjörn, van der Post, Sjoerd   +12 more
core   +1 more source