Results 121 to 130 of about 21,196 (261)

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis [PDF]

, 2015
Objective. IL-9 has been shown to be upregulated before the clinical onset of articular disease in RA. The exact role of IL-9 and Th9 cells in RA, however, has not yet been adequately studied.
ALESSANDRO, Riccardo, CICCIA, Francesco, DIELI, Francesco, Giardina, G., GUGGINO, Giuliana, Manna, M., Manzo, A., Montecucco, C., Rizzo, A., SIRECI, Guido, TRIOLO, Giovanni, Vitolo, B.   +11 more
core   +2 more sources

Thymic stromal lymphopoietin production induced by skin irritation results from concomitant activation of protease‐activated receptor 2 and interleukin 1 pathways

British Journal of Dermatology, 2019
Thymic stromal lymphopoietin (TSLP) mediates proallergic T helper 2‐type responses by acting on leucocytes. Endogenous pathways regulating TSLP production are poorly defined.
D. Redhu, Kristin Franke, Vandana Kumari, Wojciech Francuzik, Magda Babina, Margitta Worm   +5 more
semanticscholar   +1 more source

Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications—An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS) and asthma are prevalent conditions that often coexist. These diseases share common inflammatory mechanisms, such as T‐helper cell 2 (T2)‐high inflammation, driven by interleukin (IL)‐4, IL‐5, and IL‐13 cytokines.
Sanna Toppila‐Salmi, Sietze Reitsma, Valérie Hox, Simon Gane, Philippe Gevaert, Juan Maza‐Solano, Alma Helevä, Ida Sulku, Kaisa Santala, Iiris Kangasniemi, Ludger Klimek, Adam Chaker, Aspasia Karavelia, Michael Rudenko, Oliver Pfaar, Laura Van Gerven, Shaari Ariana, Michele Schiappoli, Marie Lundberg, Jan Hagemann, Ibon Eguíluz‐Gracia, Andre Moreira   +21 more
wiley   +1 more source

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma

Cell Communication and Signaling, 2008
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype.
Kuepper Michael, Borowski Andreas, Sebastian Katrin, Friedrich Karlheinz   +3 more
doaj   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Evaluation of mucosal adjuvants and immunization routes for the induction of systemic and mucosal humoral immune responses in macaques

, 2015
Delivering vaccine antigens to mucosal surfaces is potentially very attractive, especially as protection from mucosal infections may be mediated by local immune responses.
Buffa, V, Doyle-Meyers, L, Fischetti, L, King, DF, Klein, K, Shattock, RJ, Siddiqui, A, Tregoning, JS, Veazey, RS   +8 more
core   +2 more sources

Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma [PDF]

, 2012
Background Biomarkers facilitate early detection of disease and measurement of therapeutic efficacy, both at clinical and experimental levels. Recent advances in analytics and disease models allow comprehensive screening for biomarkers in complex ...
Beaumont, Maribel, de Waal Malefyt, Rene, Emson, Claire, Fick, Robert B., Li, Ying, Louten, Jennifer, Malinao, Maria-Christina, Mattson, Jeanine D., McClanahan, Terrill K., NC DOCKS at East Carolina University, Van Scott, Michael R., Vega, Felix, Wardle, Robert L.   +12 more
core   +3 more sources

Tumor-derived Thymic stromal lymphopoietin expands bone marrow B-cell precursors in circulation to support metastasis.

Cancer Research, 2019
Immature B cells in the bone marrow (BM) emigrate into the spleen during adult lymphopoiesis. Here, we report that emigration is shifted to earlier B-cell stages in mice with orthotopic breast cancer, spontaneous ovarian cancer, and possibly in human ...
Emeline Ragonnaud, Kanako Moritoh, M. Bodogai, Fedor Gusev, S. Garaud, Chen Chen, Xin Wang, Tuvshintugs Baljinnyam, K. Becker, R. Maul, K. Willard-Gallo, E. Rogaev, A. Biragyn   +12 more
semanticscholar   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source