Results 121 to 130 of about 16,647 (226)

The Effect of Thymic Stromal Lymphopoietin on Reflux Esophagitis

Journal of Physiological Investigation
Reflux esophagitis (RE) is characterized by the infiltration of inflammatory cells into the damaged squamous epithelium. Thymic stromal lymphopoietin (TSLP) has been implicated in promoting T helper type 2 (Th2) inflammation.
Ruidong Chen, Longfei Zhao, Yunyun Hu, Hong Li   +3 more
doaj   +1 more source

Thymic stromal lymphopoietin levels are increased in patients with celiac disease

Biomolecules & Biomedicine, 2019
Thymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells in the lungs, skin, and intestinal mucosa and is involved in several physiological and pathological processes.
Evrim Kahramanoğlu Aksoy, Muhammet Yener Akpınar, Ferdane Pirinççi Sapmaz, Özlem Doğan, Metin Uzman, Yaşar Nazlıgül   +5 more
doaj   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

TSLP is involved in expansion of early thymocyte progenitors

BMC Immunology, 2007
Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil, Jiang Qi, Kondo Motonari, Su Lishan   +3 more
doaj   +1 more source

The last step to achieve barrier damage control

Frontiers in Immunology
Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role ...
Ilaria Baglivo, Stefania Colantuono, Arianna Lumaca, Alfredo Papa, Antonio Gasbarrini, Cristiano Caruso   +5 more
doaj   +1 more source

A Comparison for Type 2 Cytokines and Lesional Inflammatory Infiltrations in Bullous Pemphigoid and Atopic Dermatitis

Clinical, Cosmetic and Investigational Dermatology, 2022
Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
doaj  

Potential of alarmin-targeted bispecific and combination therapies in airway disease

Frontiers in Allergy
Thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 are epithelial-derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).
H. Kiyomi Komori, Hector Ortega
doaj   +1 more source

Mechanistic study on the alleviation of LPS-induced hepatocyte injury by thymic stromal lymphopoietin

Guangxi Yike Daxue xuebao
Objective To explore the mechanism of thymic stromal lymphopoietin (TSLP) in regulating lipopolysaccharide (LPS) -induced inflammation in mouse hepatocytes. Methods Ten male C57BL/6J wild-type (WT) mice and 10 male TSLP receptor-deficient (TSLPR-/-) mice
Jiarui ZHANG, Shaolei WU, Shilai LI
doaj   +1 more source

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core