Results 11 to 20 of about 21,196 (261)

Thymic stromal lymphopoietin in dermatological diseases

Clinical Dermatology Review, 2020
Thymic stromal lymphopoietin is an epithelial cell-derived cytokine expressed in gut, lungs, skin, and thymus. It affects both the local dermal dendritic cells (DCs) and the circulating myeloid DCs.
Mohamed Ibrahim ElGhareeb
doaj   +2 more sources

Thymic Stromal Lymphopoietin and Tezepelumab in Airway Diseases: From Physiological Role to Target Therapy. [PDF]

Int J Mol Sci
Thymic stromal lymphopoietin (TSLP), is a protein belonging to a class of epithelial cytokines commonly called alarmins, which also includes IL-25 and IL-33. Functionally, TSLP is a key player in the immune response to environmental insults, initiating a
Bagnasco D, De Ferrari L, Bondi B, Candeliere MG, Mincarini M, Riccio AM, Braido F.   +6 more
europepmc   +2 more sources

Thymic stromal lymphopoietin in leukemia: A double-edged sword? [PDF]

Leukemia Research Reports
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou, Mengmeng Gu, Yue Su, Dayong Yao, Hao Gang, Yang Li, Ce Shi   +6 more
doaj   +2 more sources

Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase. [PDF]

Int J Mol Sci
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP).
Canè L, Poto R, Palestra F, Iacobucci I, Pirozzi M, Parashuraman S, Ferrara AL, Illiano A, La Rocca A, Mercadante E, Pucci P, Marone G, Spadaro G, Loffredo S, Monti M, Varricchi G.   +15 more
europepmc   +2 more sources

Inhibition of thymic stromal lymphopoietin production by FK3453

Journal of Pharmacological Sciences, 2022
To prevent the onset and aggravation of allergic diseases, it is necessary to modulate excessive Th2-type immune responses. It is well accepted that thymic stromal lymphopoietin (TSLP) plays important roles in the change of Th1/Th2 balance to Th2 ...
Ryosuke Segawa, Ryosuke Ishihara, Masahiro Hiratsuka, Noriyasu Hirasawa   +3 more
doaj   +3 more sources

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

Medicina, 2020
Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as
Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Hyun-Woo Jee, Ji-Hyeon Kim, Hyung-Min Kim, Hyun-Ja Jeong   +6 more
doaj   +2 more sources

Thymic Stromal Lymphopoietin Induction Suppresses Lung Cancer Development

Cancers, 2022
Simple Summary The recurrence rate for lung cancer is high after the removal of the primary tumor. Herein, we demonstrate the potential of immunotherapy against lung cancer by examining the impact of Thymic Stromal Lymphopoietin (TSLP) cytokine induction
R. Guennoun, Jennet Hojanazarova, Kathryn E Trerice, M. Azin, Matthew T. McGoldrick, Erik B. Schiferle, Michael P. Stover, S. Demehri   +7 more
semanticscholar   +3 more sources

Tezepelumab, an anti–thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial

Journal of the American Academy of Dermatology, 2019
Background: Tezepelumab (AMG 157/MEDI9929), a first‐in‐class monoclonal antibody, targets thymic stromal lymphopoietin, a cytokine that is implicated in the pathogenesis of atopic dermatitis (AD).
E. Simpson, J. Parnes, D. She, Sarah Crouch, W. Rees, M. Mo, R. van der Merwe   +6 more
exaly   +2 more sources

Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms

Frontiers in Immunology, 2020
The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti, Maria Pia Protti, Lucia De Monte, Lucia De Monte   +3 more
doaj   +2 more sources

Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL [PDF]

Cells, 2019
Mast cells (MCs) play critical roles in allergic and inflammatory reactions and contribute to multiple pathologies in the skin, in which they show increased numbers, which frequently correlates with severity. It remains ill-defined how MC accumulation is
Babina, Magda, Eberle, Jürgen, Hazzan, Tarek, Worm, Margitta   +3 more
core   +2 more sources