Results 21 to 30 of about 16,647 (226)

Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic ...
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee   +8 more
doaj   +1 more source

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells [PDF]

The Journal of Immunology, 2001
AbstractThe sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family ...
Reche Gallardo, Pedro Antonio, Soumelis, Vassili, Gorman, D M, Clifford, T, Liu, MR, Travis, M, Zurawski, Sandra M., Johnston, J, Liu, Yong-Jun, Spits, H, Waal-Malefyt, Rene de, Kastelein, Robert A., Bazan, Fernando   +12 more
openaire   +4 more sources

Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903‐induced Skin Inflammation [PDF]

Eur J Immunol
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon ...
González‐Rodríguez M, Salomaa T, Cabalin C, Komulainen T, Hiihtola L, Kummola L, Järvinen T, Junttila I.   +7 more
europepmc   +2 more sources

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

Down-regulation of thymic stromal lymphopoietin by curcumin [PDF]

Pharmacological Reports, 2013
Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the pathogenesis of allergic diseases such as asthma, atopic dermatitis and allergic rhinitis. Curcumin has various effects such as antidepressant, antioxidant, antihyperglycemic, antitumor and anti-inflammatory.
Phil-Dong, Moon, Hyun-Ja, Jeong, Hyung-Min, Kim   +2 more
openaire   +2 more sources

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]

, 2017
BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz, Andras Schaffer, Arturo P. Saavedra, Cipolat, Fenske, Hengameh Mirzaalian, Jean-Pierre Eliane, Lynn A. Cornelius, Mary Tabacchi, Michael Wallendorf, Raphael Kopan, Salasche, Sara Moradi Tuchayi, Seckin, Shadmehr Demehri, Sindhu Manivasagam, Stockfleth, Trevor J. Cunningham, Warino   +18 more
core   +2 more sources

Cryoglobulinemic Glomerulonephritis in Thymic Stromal Lymphopoietin Transgenic Mice [PDF]

The American Journal of Pathology, 2001
Mixed cryoglobulins are complexes of immunoglobulins that reversibly precipitate in the cold and lead to a systemic disease in humans. Renal involvement usually manifests as a membranoproliferative glomerulonephritis with marked monocyte infiltration and, at times, intracapillary thrombi.
S, Taneda, S, Segerer, K L, Hudkins, Y, Cui, M, Wen, M, Segerer, M H, Wener, C G, Khairallah, A G, Farr, C E, Alpers   +9 more
openaire   +2 more sources

Effects of Resveratrol on Thymic Stromal Lymphopoietin Expression in Mast Cells

Medicina, 2020
Background and objectives: Cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathogenesis of atopic diseases such as atopic dermatitis, allergic rhinitis, and asthma. Resveratrol (RSV) exerts various pharmacological effects such as
Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Hyun-Woo Jee, Ji-Hyeon Kim, Hyung-Min Kim, Hyun-Ja Jeong   +6 more
doaj   +1 more source

A thymic stromal lymphopoietin szerepe a bőrben és egyéb barriereken [PDF]

, 2018
L
Béke, Gabriella, Dajnoki, Zsolt, Kapitány, Anikó, Szegedi, Andrea   +3 more
core   +1 more source

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Haematologica, 2016
Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell precursors. However, its in vivo role during normal human B lymphopoiesis is unknown.
Olivia L. Francis, Terry-Ann M. Milford, Shannalee R. Martinez, Ineavely Baez, Jacqueline S. Coats, Karina Mayagoitia, Katherine R. Concepcion, Elizabeth Ginelli, Cornelia Beldiman, Abigail Benitez, Abby J. Weldon, Keshav Arogyaswamy, Parveen Shiraz, Ross Fisher, Christopher L. Morris, Xiao-Bing Zhang, Valeri Filippov, Ben Van Handel, Zheng Ge, Chunhua Song, Sinisa Dovat, Ruijun Jeanna Su, Kimberly J. Payne   +22 more
doaj   +1 more source