Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. [PDF]
, 2017 The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift in the understanding of allergic airway disease pathogenesis.
Cavagnero, Kellen, Doherty, Taylor A
core +2 more sources
Acta Dermato-Venereologica, 2019 Prurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in ...
Weilong Zhong +9 more
doaj +1 more source
TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling [PDF]
, 2014 Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an
Huang, Tai-Chung +11 more
core +1 more source
Thymic Stromal Lymphopoietin Induces Migration in Human Airway Smooth Muscle Cells [PDF]
, 2014 Airway remodeling due to increased airway smooth muscle (ASM) mass, likely due to enhanced migration and proliferation, has been shown to be highly associated with decline in lung function in asthma.
Gounni, Abdelilah S. +3 more
core +1 more source
Thymic stromal lymphopoietin and allergic disease [PDF]
Journal of Allergy and Clinical Immunology, 2012 The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways, and gastrointestinal tract.
openaire +2 more sources
Exacerbation of Allergic Diseases by Chemicals: Role of TSLP
Journal of Pharmacological Sciences, 2014 Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj +1 more source
TSLP expression in the skin is mediated via RAR-RXR pathways [PDF]
, 2018 K
de Lera, Ángel R. +6 more
core +1 more source
The Biology of Thymic Stromal Lymphopoietin (TSLP) [PDF]
, 2013 Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Steven F, Ziegler +5 more
openaire +2 more sources
Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects [PDF]
, 2012 BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases.
Claus Bachert +4 more
core +2 more sources
Thymic Stromal Lymphopoietin Is Produced by Dendritic Cells [PDF]
The Journal of Immunology, 2011 Abstract Thymic stromal lymphopoietin (TSLP) is a type 1 cytokine that contributes to lymphopoiesis and the development of asthma and atopic dermatitis. TSLP acts on multiple lineages, including dendritic cells (DCs), T cells, NKT cells, eosinophils, and mast cells, mediating proliferation and survival and linking innate and adaptive ...
Mohit, Kashyap +4 more
openaire +2 more sources