Results 31 to 40 of about 21,196 (261)

Thymic Stromal Lymphopoietin and Cancer [PDF]

The Journal of Immunology, 2014
Abstract Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging effects on both hematopoietic and nonhematopoietic cell lineages. These include dendritic cells, basophils, mast cells, B cells, epithelial cells, and CD4+, CD8+, and NK T cells. Although TSLP’s
Emma, Lo Kuan, Steven F, Ziegler
openaire   +2 more sources

Use of the complex of models of regression for analysis of the factors that determine the severity of bronchial asthma [PDF]

, 2020
Background: According to an International Study of Asthma and Allergies in Childhood (ISAAC), the prevalence of asthma in children of 6-7 years old has increased by 10%, and at the age of 13-14 years by 16% over the last decade.
Kozhyna, Olga S., Pihnastyi, O. M.
core   +2 more sources

Mucosal Overexpression of Thymic Stromal Lymphopoietin and Proinflammatory Cytokines in Patients With Autoimmune Atrophic Gastritis

Clinical and Translational Gastroenterology, 2022
INTRODUCTION: The immune mechanisms underlying human autoimmune atrophic gastritis (AAG) are poorly understood. We sought to assess immune mucosal alterations in patients with AAG.
M. Lenti, F. Facciotti, E. Miceli, A. Vanoli, G. Fornasa, E. Lahner, I. Spadoni, P. Giuffrida, Giovanni Arpa, A. Pasini, L. Rovedatti, F. Caprioli, C. Travelli, G. Lattanzi, L. Conti, C. Klersy, M. Vecchi, M. Paulli, B. Annibale, G. Corazza, M. Rescigno, A. Di Sabatino   +21 more
semanticscholar   +1 more source

The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis

Clinical Respiratory Journal, 2022
Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and remodeling, whereas
Xuefeng Xu, H. Dai, Jing-lan Zhang
semanticscholar   +1 more source

Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that plays a key role in Th2-mediated inflammation, both directly by promoting the proliferation of naïve CD4 Th2 cells, and indirectly by activating dendritic ...
Hea Yon Lee, Hwa Young Lee, Jung Hur, Hye Seon Kang, Joon Young Choi, Chin Kook Rhee, Ji Young Kang, Young Kyoon Kim, Sook Young Lee   +8 more
doaj   +1 more source

Thymic stromal lymphopoietin induces platelet mitophagy and promotes thrombosis in Kawasaki disease

British Journal of Haematology, 2022
Kawasaki disease (KD) is an acute systemic vasculitis primarily affecting infants and children. Activated platelets predispose patients to coronary artery structural lesions that may lead to thrombotic cardiovascular events.
Lanyan Fu, Daniel T. MacKeigan, Qing Gong, Di Che, Yufen Xu, Lei Pi, Chaonan Sun, Hongyan Yu, Kaining Chen, Huazhong Zhou, Zhiyong Jiang, Zhouping Wang, Li Zhang, Eric G. Cerenzia, H. Ni, Xiaoqiong Gu   +15 more
semanticscholar   +1 more source

Human Thymic Stromal Lymphopoietin Preferentially Stimulates Myeloid Cells [PDF]

The Journal of Immunology, 2001
AbstractThe sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family ...
Reche Gallardo, Pedro Antonio, Soumelis, Vassili, Gorman, D M, Clifford, T, Liu, MR, Travis, M, Zurawski, Sandra M., Johnston, J, Liu, Yong-Jun, Spits, H, Waal-Malefyt, Rene de, Kastelein, Robert A., Bazan, Fernando   +12 more
openaire   +4 more sources

Thymic stromal lymphopoietin: its role and potential as a therapeutic target in asthma

Expert opinion on therapeutic targets, 2020
Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a central regulator of the immune response to inhaled environmental insults such as allergens, viruses and pollutants, initiating a cascade of downstream inflammation.
G. Gauvreau, R. Sehmi, C. Ambrose, J. Griffiths   +3 more
semanticscholar   +1 more source

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Cells, 2021
Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD).
M. Babina, Zhao Wang, K. Franke, T. Zuberbier   +3 more
semanticscholar   +1 more source

A thymic stromal lymphopoietin szerepe a bőrben és egyéb barriereken [PDF]

, 2018
L
Béke, Gabriella, Dajnoki, Zsolt, Kapitány, Anikó, Szegedi, Andrea   +3 more
core   +1 more source