Results 61 to 70 of about 21,196 (261)

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells [PDF]

, 2013
Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses.
Ghaemmaghami, Amir M., Salazar, Fabian
core   +1 more source

Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease [PDF]

, 2015
OBJECTIVE: The short isoform of thymic stromal lymphopoietin (TSLP), a cytokine constitutively expressed by epithelial cells, is crucial in preserving immune tolerance in the gut.
Alastair Forbes, Alessandra Pasini, Alessandro Vanoli, Andoh, Antonio Di Sabatino, Biancheri, Bjerkan, Caruso, Christmann, Ciccocioppo, Ciccocioppo, Cinzia Papadia, Comeau, Corazza, Cristina Ubezio, Datta, Daum, Di Sabatino, Di Sabatino, Di Sabatino, Di Sabatino, Eleanor Wood, Fornasa, Gino R Corazza, Giulia Fornasa, He, Iliev, Iliev, Iliev, Kashyap, Katerina Tsilingiri, Liu, Maria Rescigno, Monteleone, Monteleone, Nagarkar, Otte, Paolo Biancheri, Paolo Giuffrida, Pender, Pender, Rescigno, Rimoldi, Roan, Rubio-Tapia, Spadoni, Sylvia L F Pender, Takai, Thomas, Thomas T MacDonald, Usategui, Vaira, Zhou, Ziegler   +53 more
core   +1 more source

Thymic stromal lymphopoietin: a new cytokine in asthma [PDF]

Current Opinion in Pharmacology, 2008
Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans.
Yrina, Rochman, Warren J, Leonard
openaire   +2 more sources

Virtual screening for inhibitors of the human TSLP:TSLPR interaction [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis.
AA Bogan, AC Braisted, AJ Souers, C Ghirelli, D Sun, DR Hall, G Neudert, G Pérez-Hernández, GM Gauvreau, HH Loeffler, J Corren, J Felix, J Yin, JM Wang, K Lindorff-Larsen, K Verstraete, K Verstraete, L Deng, LS Park, M Guillot-Delost, M Noti, M Piazza Di, MJ Abraham, NS Redhu, O Trott, P Buchwald, P Chames, RL Rich, S Demehri, S Doerr, S Ulrich, SD Levin, SF Ziegler, T Clackson   +33 more
core   +2 more sources

Thymic stromal lymphopoietin does not activate human basophils [PDF]

Journal of Allergy and Clinical Immunology, 2018
International ...
Salabert-Le Guen, Nina, Hemont, Caroline, Delbove, Agathe, Poli, Caroline, Braudeau, Cécile, Fantou, Aurelie, Amouriaux, Karine, Bériou, Gaëlle, Martin, Jerome C, Colas, Luc, Soumelis, Vassili, Josien, Regis   +11 more
openaire   +4 more sources

Az atópiás dermatitis patomechanizmusa [PDF]

, 2018
L
Steuer-Hajdu, Krisztina, Szegedi, Andrea
core   +1 more source

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. [PDF]

, 2017
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown.
Alain Hovnanian, Alculumbre, Andrea Cavani, Andrea Chiricozzi, Ballesteros-Tato, Bernasconi, Bernhard Homey, Brandt, Briot, Bryant, Choi, Coline Trichot, Coquet, Crotty, Deenick, Elisabetta Volpe, Furio, Giacomin, Glatman Zaretsky, Gould, Grewe, Gringhuis, Hatzi, He, Hovnanian, Ito, Ito, Jacquemin, Kemeny, Kim, Kroenke, Kusam, Leyva-Castillo, Liang, Liu, Locci, Lonati, Lucia Pattarini, Ma, Ma, Marco Romanelli, Maximilien Grandclaudon, Melanie Durand, Morita, Nakazawa, Nies, Niu, O’Shea, Pène, Ramalingam, Schmitt, Schmitt, Schmitt, Shin, Sofia Bogiatzi, Soumelis, Stefania Madonna, Stephan Meller, Tangye, Toshiyuki Hori, Trinchieri, Ueno, Van Roey, Vassili Soumelis, Volpe, Volpe, Wang, Weinstein, Ying, Yusuf, Zela Keuylian, Ziegler   +71 more
core   +3 more sources

Thymic stromal lymphopoietin deficiency attenuates experimental autoimmune encephalomyelitis [PDF]

Clinical and Experimental Immunology, 2015
SummaryIn the present study we examined the role of thymic stromal lymphopoietin (TSLP) in experimental autoimmune encephalomyelitis (EAE). Here, we report that TSLP knock-out (KO) mice display a delayed onset of disease and an attenuated form of EAE. This delayed onset was accompanied by a reduced number of encephalitogenic T helper type 1 (Th1) cells
J, Eckhardt, M, Döbbeler, C, König, K, Kuczera, C, Kuhnt, C, Ostalecki, E, Zinser, T W, Mak, A, Steinkasserer, M, Lechmann   +9 more
openaire   +2 more sources

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +1 more source

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]

, 2019
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M, Bautista, Diana M, Brem, Rachel B, Brock, Emily C, Deguine, Jacques, Gronert, Karsten, Hill, Rose Z, Kucirek, Natalie, Rifi, Ziad, Schwendinger-Schreck, Jamie, Walsh, Carolyn M, Wei, Jessica   +11 more
core   +1 more source