Results 91 to 100 of about 12,710 (220)

Tissue signals imprint ILC2 identity with anticipatory function. [PDF]

, 2018
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP).
Eckalbar, Walter L, Erle, David J, Lee, Jinwoo, Liang, Hong-Erh, Locksley, Richard M, Molofsky, Ari B, Nussbaum, Jesse C, Ricardo-Gonzalez, Roberto R, Schneider, Christoph, Vaka, Dedeepya, Van Dyken, Steven J   +10 more
core  

Potential involvement of IL-9 and Th9 cells in the pathogenesis of rheumatoid arthritis [PDF]

, 2015
Objective. IL-9 has been shown to be upregulated before the clinical onset of articular disease in RA. The exact role of IL-9 and Th9 cells in RA, however, has not yet been adequately studied.
ALESSANDRO, Riccardo, CICCIA, Francesco, DIELI, Francesco, Giardina, G., GUGGINO, Giuliana, Manna, M., Manzo, A., Montecucco, C., Rizzo, A., SIRECI, Guido, TRIOLO, Giovanni, Vitolo, B.   +11 more
core   +2 more sources

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

Interleukin (IL)‐5, Eosinophils and IL‐5 Pathway Inhibitors in Eosinophilic Granulomatosis with Polyangiitis.

Arthritis &Rheumatology, Accepted Article.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Verekitug, a Novel Antibody Antagonist to the TSLP Receptor in Adults with Asthma: A 32‐Week Randomized Phase 1b Multiple Ascending‐Dose Trial

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 782-790, March 2026.
Verekitug, a novel, high‐affinity, fully human monoclonal antibody targeting thymic stromal lymphopoietin receptor (TSLPR), is in development as a potential treatment for severe asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and chronic obstructive pulmonary disease (COPD).
Dave Singh, Chaim M. Brickman, Peter Lloyd, Ashish Kalra, Subhabrata Biswas, Arkadeep Sinha, Alex Mulvanny, Sumathi Sivapalasingam, Oren M. Becker, Aaron Deykin   +9 more
wiley   +1 more source

LINFOPOYETINA ESTROMAL TÍMICA: REGULACIÓN DE LA RESPUESTA INMUNE Y LA ENFERMEDAD ALÉRGICA

Universitas Scientiarum, 2007
Recientemente se ha descrito una citocina similar a interleucina (IL) 7: Thymic Stromal Lymphopoietin (TSLP). La molécula TSLP es secretada por células epiteliales y en humanos estimula principalmente células de linaje mieloide, a diferencia del ratón ...
A. Cuéllar
doaj  

TSLP and Immune Homeostasis

Allergology International, 2012
In an immune system, dendritic cells (DCs) are professional antigen-presenting cells (APCs) as well as powerful sensors of danger signals. When DCs receive signals from infection and tissue stress, they immediately activate and instruct the initiation of
Shino Hanabuchi, Norihiko Watanabe, Yong-Jun Liu   +2 more
doaj   +1 more source

TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice [PDF]

, 2017
TGF-βRII signaling prevents the development of Hassall's ...
Boyd, Richard, Hauri-Hohl, Mathias, Holländer, Georg A., Matsumoto, Mitsuru, Nishikawa, Yomiko, Odaka, Chikako, Takizawa, Kazuya, Yano, Masashi   +7 more
core  

Accumulation of prelamin A compromises NF-kB-regulated B-lymphopoiesis in progeria mouse model. [PDF]

, 2013
published_or_final_versio
Liu, B, Liu, X, Zhang, F, Zhou, K, ZHOU, S, Zhou, Z   +5 more
core   +1 more source

Mucosal vaccination with long-form TSLP induces migratory cDC1-mediated adaptive immunity against SARS-CoV-2 infection

Journal of Virology
A combination of vaccination strategies will potentially be required for effective control of the virus pandemic. We report that mice intranasally immunized with commercial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit vaccines ...
Jing Hu, Housheng Zheng, Wei Ran, Xuefei Wang, Chenghui Liao, Jian Zhou, Liang Ye   +6 more
doaj   +1 more source