Results 11 to 20 of about 12,710 (220)

The Role of Thymic Stromal Lymphopoietin (TSLP) in Glomerulonephritis [PDF]

Childhood Kidney Diseases, 2018
Thymic stromal lymphopoietin (TSLP) is an interleukin-7-like cytokine that is an important trigger and initiator of many allergic diseases. TSLP promotes a T-helper type 2 (Th2) cytokine response that can be pathological. A relationship is formed both at
Keum Hwa Lee, Jae Won Yang, Jin Young Cho, Joo Yup Lee, Eun Kyung Lim, Michael Eisenhut, Dong Yeon Jeong, Johanna Steingroever, Jae Il Shin   +8 more
doaj   +4 more sources

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma [PDF]

Cell Communication and Signaling, 2008
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype.
Kuepper Michael, Borowski Andreas, Sebastian Katrin, Friedrich Karlheinz   +3 more
doaj   +3 more sources

Regulation of Thymic Stromal Lymphopoietin (TSLP) receptor expression [PDF]

Allergy, Asthma & Clinical Immunology, 2010
Objective/purpose TSLP plays a major role in the induction and effector phases of allergic diseases by acting on dendritic cells, mast cells (MCs), T cells and CD34 hemopoietic progenitor cells. Whereas the cellular origin and the mechanisms regulating TSLP production are well documented, little is known about the regulation of TSLP receptor expression.
Allakhverdi Zoulfia, Delespesse Guy
doaj   +3 more sources

S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty. [PDF]

Respir Res, 2023
Abstract Rationale Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe asthma after considering biologics therapy.
Gagnon PA, Klein M, De Vos J, Biardel S, Côté A, Godbout K, Laviolette M, Laprise C, Assou S, Chakir J.   +9 more
europepmc   +5 more sources

The biology of thymic stromal lymphopoietin (TSLP). [PDF]

Adv Pharmacol, 2013
Originally shown to promote the growth and activation of B cells, thymic stromal lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic and nonhematopoietic cell lineages, including dendritic cells, basophils, eosinophils, mast cells, CD4⁺, CD8⁺ and natural killer T cells, B cells and epithelial cells. While TSLP's role in
Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H.   +5 more
europepmc   +4 more sources

Thymic Stromal Lymphopoietin (TSLP) Is Cleaved by Human Mast Cell Tryptase and Chymase. [PDF]

Int J Mol Sci
Thymic stromal lymphopoietin (TSLP), mainly expressed by epithelial cells, plays a central role in asthma. In humans, TSLP exists in two variants: the long form TSLP (lfTSLP) and a shorter TSLP isoform (sfTSLP). Macrophages (HLMs) and mast cells (HLMCs) are in close proximity in the human lung and play key roles in asthma.
Canè L, Poto R, Palestra F, Iacobucci I, Pirozzi M, Parashuraman S, Ferrara AL, Illiano A, La Rocca A, Mercadante E, Pucci P, Marone G, Spadaro G, Loffredo S, Monti M, Varricchi G.   +15 more
europepmc   +4 more sources

Role of the TSLP and its Receptor in the Treatment of Asthma

Barcelona Respiratory Network Reviews, 2023
Thymic stromal lymphopoietin (TSLP) is a crucial cytokine in initiating and regulating immune responses. Various cell types, including epithelial cells, fibroblasts, and dendritic cells, synthesize TSLP. TSLP activates dendritic cells, which subsequently
Miguel Estravís, Ignacio Dávila, Asunción García-Sánchez   +2 more
doaj   +1 more source

Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms

Frontiers in Immunology, 2020
The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti, Maria Pia Protti, Lucia De Monte, Lucia De Monte   +3 more
doaj   +1 more source

Multiple Functions of the New Cytokine-Based Antimicrobial Peptide Thymic Stromal Lymphopoietin (TSLP). [PDF]

Pharmaceuticals (Basel), 2016
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a short, constitutively-expressed form (sfTSLP), that appears to be ...
Bjerkan L, Sonesson A, Schenck K.
europepmc   +5 more sources

TSLP activates the production of IFN-γ via CD8-positive T cells in recurrent tonsillitis

Clinical Immunology Communications, 2022
The role of thymic stromal lymphopoietin (TSLP) in chronic infection is not well understood. We report an increased number of cluster of differentiation 8 (CD8+ T) cells and higher expression of TSLP in the tonsil tissues of patients with recurrent ...
Kota Hiraoka, Toshiaki Kawano, Takashi Hirano, Masashi Urabe, Kaori Tateyama, Masashi Suzuki   +5 more
doaj   +1 more source