Results 21 to 30 of about 12,839 (218)

Multiple Functions of the New Cytokine-Based Antimicrobial Peptide Thymic Stromal Lymphopoietin (TSLP). [PDF]

Pharmaceuticals (Basel), 2016
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine, hitherto mostly known to be involved in inflammatory responses and immunoregulation. The human tslp gene gives rise to two transcription and translation variants: a long form (lfTSLP) that is induced by inflammation, and a short, constitutively-expressed form (sfTSLP), that appears to be ...
Bjerkan L, Sonesson A, Schenck K.
europepmc   +5 more sources

Thymic Stromal Lymphopoietin: To Cut a Long Story ShortSummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Thymic stromal lymphopoietin (TSLP) was identified more than 20 years ago as a secreted factor of a mouse thymic stromal cell line; later, a human orthologue was also identified.
Katerina Tsilingiri, Giulia Fornasa, Maria Rescigno   +2 more
doaj   +1 more source

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma [PDF]

Mucosal Immunology, 2012
Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as the "atopic march." Although the ...
Han, Hongwei, Xu, Whitney, Headley, Mark B., Jessup, Heidi K., Lee, Karen S., Omori, Miyuki, Comeau, Michael R., Marshak-Rothstein, Ann, Ziegler, Steven F.   +8 more
openaire   +2 more sources

Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype [PDF]

Mucosal Immunology, 2015
Recent candidate gene and genome-wide association studies have identified "protective" associations between the single-nucleotide polymorphism (SNP) rs1837253 in the TSLP gene and risk for allergy, asthma, and airway hyperresponsiveness. The absence of linkage disequilibrium of rs1837253 with other SNPs in the region suggests it is likely a causal ...
C C K, Hui, A, Yu, D, Heroux, L, Akhabir, A J, Sandford, H, Neighbour, J A, Denburg   +6 more
openaire   +6 more sources

Exacerbation of Allergic Diseases by Chemicals: Role of TSLP

Journal of Pharmacological Sciences, 2014
Environmental chemicals, such as cigarette smoke and diesel exhaust, have been reported as risk factors that exacerbate allergic diseases. However, the exacerbation mechanisms induced by these chemicals are not yet fully understood.
Ryosuke Segawa, Noriyasu Hirasawa
doaj   +1 more source

Natural Compounds Targeting Thymic Stromal Lymphopoietin (TSLP): A Promising Therapeutic Strategy for Atopic Dermatitis. [PDF]

Biomolecules
Atopic dermatitis (AD) is a chronic inflammatory skin disease with rising prevalence, marked by eczematous lesions, itching, and a weakened skin barrier often tied to filaggrin gene mutations. This breakdown allows allergen and microbe entry, with thymic stromal lymphopoietin (TSLP) playing a crucial role by activating immune pathways that amplify the ...
Suleman M, Moltrasio C, Tricarico PM, Marzano AV, Crovella S.   +4 more
europepmc   +4 more sources

Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy [PDF]

, 2017
BACKGROUND. Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments.
Ahu Turkoz, Andras Schaffer, Arturo P. Saavedra, Cipolat, Fenske, Hengameh Mirzaalian, Jean-Pierre Eliane, Lynn A. Cornelius, Mary Tabacchi, Michael Wallendorf, Raphael Kopan, Salasche, Sara Moradi Tuchayi, Seckin, Shadmehr Demehri, Sindhu Manivasagam, Stockfleth, Trevor J. Cunningham, Warino   +18 more
core   +2 more sources

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

Frontiers in Immunology, 2018
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin ...
Gilda Varricchi, Gilda Varricchi, Antonio Pecoraro, Antonio Pecoraro, Giancarlo Marone, Giancarlo Marone, Gjada Criscuolo, Gjada Criscuolo, Giuseppe Spadaro, Giuseppe Spadaro, Arturo Genovese, Arturo Genovese, Gianni Marone, Gianni Marone, Gianni Marone   +14 more
doaj   +1 more source

A thymic stromal lymphopoietin szerepe a bőrben és egyéb barriereken [PDF]

, 2018
L
Béke, Gabriella, Dajnoki, Zsolt, Kapitány, Anikó, Szegedi, Andrea   +3 more
core   +1 more source