Results 31 to 40 of about 12,839 (218)

TSLP signaling pathway map: a platform for analysis of TSLP-mediated signaling [PDF]

, 2014
Thymic stromal lymphopoietin (TSLP) is a four-helix bundle cytokine that plays a critical role in the regulation of immune responses and in the differentiation of hematopoietic cells. TSLP signals through a heterodimeric receptor complex consisting of an
Huang, Tai-Chung, Palapetta, Shyam Mohan, Pandey, Akhilesh, Prasad, T. S. Keshava, Raju, Rajesh, Sharma, Jyoti, Tyner, Jeffrey W., van Bodegom, Diederik, Weinstock, David M., Yoda, Akinori, Zhong, Jun, Ziegler, Steven F.   +11 more
core   +1 more source

Cytokine and Lipid Mediator Regulation of Group 2 Innate Lymphoid Cells (ILC2s) in Human Allergic Airway Disease. [PDF]

, 2017
The recent discovery of group 2 innate lymphoid cells (ILC2s) has caused a paradigm shift in the understanding of allergic airway disease pathogenesis.
Cavagnero, Kellen, Doherty, Taylor A
core   +2 more sources

Dynamic Thymic Stromal Lymphopoietin and Its Receptor Complex Expression on Skin Langerhans Cells in Response to MC903‐induced Skin Inflammation [PDF]

Eur J Immunol
Thymic Stromal Lymphopoietin (TSLP) regulates the skin microenvironment during type 2 inflammation. Epidermal APCs, Langerhans cells (LCs), might be the target of TSLP, but whether LCs express CD127 needed for TSLP signaling has been unclear. We found that LCs express both receptor chains needed by TSLP (CD127 and TSLPR) and upregulate the TSLPR upon ...
González‐Rodríguez M, Salomaa T, Cabalin C, Komulainen T, Hiihtola L, Kummola L, Järvinen T, Junttila I.   +7 more
europepmc   +2 more sources

TSLP expression in the skin is mediated via RAR-RXR pathways [PDF]

, 2018
K
de Lera, Ángel R., Gericke, Janine, Lucas, Renata, Mihály, Johanna, Rühl, Ralph, Töröcsik, Dániel, Álvarez, Susana   +6 more
core   +1 more source

A novel xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis

Haematologica, 2016
Thymic stromal lymphopoietin (TSLP) stimulates in vitro proliferation of human fetal B-cell precursors. However, its in vivo role during normal human B lymphopoiesis is unknown.
Olivia L. Francis, Terry-Ann M. Milford, Shannalee R. Martinez, Ineavely Baez, Jacqueline S. Coats, Karina Mayagoitia, Katherine R. Concepcion, Elizabeth Ginelli, Cornelia Beldiman, Abigail Benitez, Abby J. Weldon, Keshav Arogyaswamy, Parveen Shiraz, Ross Fisher, Christopher L. Morris, Xiao-Bing Zhang, Valeri Filippov, Ben Van Handel, Zheng Ge, Chunhua Song, Sinisa Dovat, Ruijun Jeanna Su, Kimberly J. Payne   +22 more
doaj   +1 more source

Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

eLife, 2021
Thymic stromal lymphopoietin (TSLP) is a cytokine that acts directly on CD4+ T cells and dendritic cells to promote progression of asthma, atopic dermatitis, and allergic inflammation.
Risa Ebina-Shibuya, Erin E West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B McGavern, Warren J Leonard   +10 more
doaj   +1 more source

Thymic Stromal Lymphopoietin Induces Migration in Human Airway Smooth Muscle Cells [PDF]

, 2014
Airway remodeling due to increased airway smooth muscle (ASM) mass, likely due to enhanced migration and proliferation, has been shown to be highly associated with decline in lung function in asthma.
Gounni, Abdelilah S., Movassagh, Hesam, Redhu, Naresh Singh, Shan, Lianyu   +3 more
core   +1 more source

TSLP is involved in expansion of early thymocyte progenitors

BMC Immunology, 2007
Background Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
Coffield V McNeil, Jiang Qi, Kondo Motonari, Su Lishan   +3 more
doaj   +1 more source

Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects [PDF]

, 2012
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine, implicated in the development and progression of allergic diseases.
Claus Bachert, Luo Zhang, Xiaohong Song, Yanming Zhao, Yuan Zhang   +4 more
core   +2 more sources

Thymic Stromal Lymphopoietin (TSLP) and Airway Smooth Muscle

The FASEB Journal, 2009
TSLP is a newly‐identified cytokine thought to be involved in airway inflammation. TSLP levels have been shown to significantly increase in airway smooth muscle (ASM) with chronic obstructive pulmonary disease and other inflammatory diseases. This study evaluated the expression of TSLP in
Dan Smelter, Michael Thompson, Lucas Meuchel, Elizabeth Townsend, Alexander Ryu, Christina Pabelick, Robert Vassallo, Y S Prakash   +7 more
openaire   +1 more source