Results 41 to 50 of about 12,710 (220)

Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation [PDF]

, 2018
Interaction between intestinal epithelial cells (IECs) and the underlying immune systems is critical for maintaining intestinal immune homeostasis and mounting appropriate immune responses.
Bacon, Bacon, Chambers, Chambers, Chu, de Jong, Fernandez, Khodoun, Lee, Li, Man, Man, Mehta, Mowat, Neill, Neutra, Peake, Peterson, Presky, Rimoldi, Sansonetti, Sato, Sorensen, Spadoni, Taylor, Temblay, Verhagen, Vidal, Wu, Wu, Wurster, Zeuthen, Ziegler, Ziegler   +33 more
core   +9 more sources

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells [PDF]

, 2013
Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses.
Ghaemmaghami, Amir M., Salazar, Fabian
core   +1 more source

Virtual screening for inhibitors of the human TSLP:TSLPR interaction [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis.
AA Bogan, AC Braisted, AJ Souers, C Ghirelli, D Sun, DR Hall, G Neudert, G Pérez-Hernández, GM Gauvreau, HH Loeffler, J Corren, J Felix, J Yin, JM Wang, K Lindorff-Larsen, K Verstraete, K Verstraete, L Deng, LS Park, M Guillot-Delost, M Noti, M Piazza Di, MJ Abraham, NS Redhu, O Trott, P Buchwald, P Chames, RL Rich, S Demehri, S Doerr, S Ulrich, SD Levin, SF Ziegler, T Clackson   +33 more
core   +2 more sources

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis [PDF]

, 2016
Advances in the field of cancer immunology, including studies on tumor-infiltrating CD8(+) cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers.
Cipolat, David G. DeNardo, Kenneth H. Ngo, Kim, Lee, Melissa A. Meyers, Osuala, Rasika Reddy, Sara Moradi Tuchayi, Shadmehr Demehri, Sindhu Manivasagam, Trevor J. Cunningham, Vena, Wayne M. Yokoyama, Yu   +14 more
core   +2 more sources

The role of thymic stromal lymphopoietin (TSLP) in allergic disorders [PDF]

Current Opinion in Immunology, 2010
The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways and gastrointestinal tract.
openaire   +2 more sources

Peripheral blood TSLP (thymic stromal lymphopoietin) in children as a biomarker?

Paediatric asthma and allergy, 2021
Introduction There is substantial evidence that alarmin TSLP plays one of the key roles in driving type 2 inflammation and it is also thought that it has a role in neutrophilic, type 2-low airway inflammation. There is much less known about the role of alarmins in type 2-low asthma and its role in the heterogeneity of inflammation in acute asthma ...
Vrsalovic, Renata, Korosec, Peter, Stojkovic, Urska Bidovec, Stefanovic, Iva Mihatov, Cicak, Biserka, Samija, Ivan, Skrgat, Sabina   +6 more
openaire   +2 more sources

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. [PDF]

, 2017
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown.
Alain Hovnanian, Alculumbre, Andrea Cavani, Andrea Chiricozzi, Ballesteros-Tato, Bernasconi, Bernhard Homey, Brandt, Briot, Bryant, Choi, Coline Trichot, Coquet, Crotty, Deenick, Elisabetta Volpe, Furio, Giacomin, Glatman Zaretsky, Gould, Grewe, Gringhuis, Hatzi, He, Hovnanian, Ito, Ito, Jacquemin, Kemeny, Kim, Kroenke, Kusam, Leyva-Castillo, Liang, Liu, Locci, Lonati, Lucia Pattarini, Ma, Ma, Marco Romanelli, Maximilien Grandclaudon, Melanie Durand, Morita, Nakazawa, Nies, Niu, O’Shea, Pène, Ramalingam, Schmitt, Schmitt, Schmitt, Shin, Sofia Bogiatzi, Soumelis, Stefania Madonna, Stephan Meller, Tangye, Toshiyuki Hori, Trinchieri, Ueno, Van Roey, Vassili Soumelis, Volpe, Volpe, Wang, Weinstein, Ying, Yusuf, Zela Keuylian, Ziegler   +71 more
core   +3 more sources

Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases

Frontiers in Immunology, 2021
Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of
Si-Hang Wang, Ya-Gang Zuo
doaj   +1 more source

A Comparison for Type 2 Cytokines and Lesional Inflammatory Infiltrations in Bullous Pemphigoid and Atopic Dermatitis

Clinical, Cosmetic and Investigational Dermatology, 2022
Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
doaj  

Az atópiás dermatitis patomechanizmusa [PDF]

, 2018
L
Steuer-Hajdu, Krisztina, Szegedi, Andrea
core   +1 more source