Results 41 to 50 of about 12,839 (218)

Sebaceous gland rich skin is characterized by TSLP expression and distinct immune surveillance which is disturbed in rosacea [PDF]

, 2017
K
Bácsi, Attila, Béke, Gabriella, Bíró, Tamás, Dajnoki, Zsolt, Gáspár, Krisztián, Hendrik, Zoltán, Juhász, István, Kapitány, Anikó, Mócsai, Gábor, Rühl, Ralph, Szegedi, Andrea, Töröcsik, Dániel, Zouboulis, Christos C.   +12 more
core   +1 more source

Virtual screening for inhibitors of the human TSLP:TSLPR interaction [PDF]

, 2017
The pro-inflammatory cytokine thymic stromal lymphopoietin (TSLP) plays a pivotal role in the pathophysiology of various allergy disorders that are mediated by type 2 helper T cell (Th2) responses, such as asthma and atopic dermatitis.
AA Bogan, AC Braisted, AJ Souers, C Ghirelli, D Sun, DR Hall, G Neudert, G Pérez-Hernández, GM Gauvreau, HH Loeffler, J Corren, J Felix, J Yin, JM Wang, K Lindorff-Larsen, K Verstraete, K Verstraete, L Deng, LS Park, M Guillot-Delost, M Noti, M Piazza Di, MJ Abraham, NS Redhu, O Trott, P Buchwald, P Chames, RL Rich, S Demehri, S Doerr, S Ulrich, SD Levin, SF Ziegler, T Clackson   +33 more
core   +2 more sources

Morphological and Functional Characterization of IL-12Rβ2 Chain on Intestinal Epithelial Cells: Implications for Local and Systemic Immunoregulation [PDF]

, 2018
Interaction between intestinal epithelial cells (IECs) and the underlying immune systems is critical for maintaining intestinal immune homeostasis and mounting appropriate immune responses.
Bacon, Bacon, Chambers, Chambers, Chu, de Jong, Fernandez, Khodoun, Lee, Li, Man, Man, Mehta, Mowat, Neill, Neutra, Peake, Peterson, Presky, Rimoldi, Sansonetti, Sato, Sorensen, Spadoni, Taylor, Temblay, Verhagen, Vidal, Wu, Wu, Wurster, Zeuthen, Ziegler, Ziegler   +33 more
core   +9 more sources

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells [PDF]

, 2013
Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses.
Ghaemmaghami, Amir M., Salazar, Fabian
core   +1 more source

Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease [PDF]

, 2015
OBJECTIVE: The short isoform of thymic stromal lymphopoietin (TSLP), a cytokine constitutively expressed by epithelial cells, is crucial in preserving immune tolerance in the gut.
Alastair Forbes, Alessandra Pasini, Alessandro Vanoli, Andoh, Antonio Di Sabatino, Biancheri, Bjerkan, Caruso, Christmann, Ciccocioppo, Ciccocioppo, Cinzia Papadia, Comeau, Corazza, Cristina Ubezio, Datta, Daum, Di Sabatino, Di Sabatino, Di Sabatino, Di Sabatino, Eleanor Wood, Fornasa, Gino R Corazza, Giulia Fornasa, He, Iliev, Iliev, Iliev, Kashyap, Katerina Tsilingiri, Liu, Maria Rescigno, Monteleone, Monteleone, Nagarkar, Otte, Paolo Biancheri, Paolo Giuffrida, Pender, Pender, Rescigno, Rimoldi, Roan, Rubio-Tapia, Spadoni, Sylvia L F Pender, Takai, Thomas, Thomas T MacDonald, Usategui, Vaira, Zhou, Ziegler   +53 more
core   +1 more source

The role of thymic stromal lymphopoietin (TSLP) in allergic disorders [PDF]

Current Opinion in Immunology, 2010
The importance of the epithelium in initiating and controlling immune responses is becoming more appreciated. For example, allergen contact first occurs at mucosal sites exposed to the external environment, such as the skin, airways and gastrointestinal tract.
openaire   +2 more sources

Peripheral blood TSLP (thymic stromal lymphopoietin) in children as a biomarker?

Paediatric asthma and allergy, 2021
Introduction There is substantial evidence that alarmin TSLP plays one of the key roles in driving type 2 inflammation and it is also thought that it has a role in neutrophilic, type 2-low airway inflammation. There is much less known about the role of alarmins in type 2-low asthma and its role in the heterogeneity of inflammation in acute asthma ...
Vrsalovic, Renata, Korosec, Peter, Stojkovic, Urska Bidovec, Stefanovic, Iva Mihatov, Cicak, Biserka, Samija, Ivan, Skrgat, Sabina   +6 more
openaire   +2 more sources

Thymic stromal lymphopoietin blocks early stages of breast carcinogenesis [PDF]

, 2016
Advances in the field of cancer immunology, including studies on tumor-infiltrating CD8(+) cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers.
Cipolat, David G. DeNardo, Kenneth H. Ngo, Kim, Lee, Melissa A. Meyers, Osuala, Rasika Reddy, Sara Moradi Tuchayi, Shadmehr Demehri, Sindhu Manivasagam, Trevor J. Cunningham, Vena, Wayne M. Yokoyama, Yu   +14 more
core   +2 more sources

Thymic Stromal Lymphopoietin in Cutaneous Immune-Mediated Diseases

Frontiers in Immunology, 2021
Thymic stromal lymphopoietin (TSLP) was initially demonstrated to be critical in regulating inflammatory responses among various allergic disorders (such as atopic dermatitis, food allergy, and asthma). Although two isoforms (short form and long form) of
Si-Hang Wang, Ya-Gang Zuo
doaj   +1 more source

TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway [PDF]

, 2010
Background Even though thymic stromal lymphopoietin (TSLP) has been implicated in the development of allergic inflammation, its influence on immune tolerance mediated by regulatory T cells (Treg) have not been explored.
Khoa D Nguyen, Christopher Vanichsarn, Kari C Nadeau   +2 more
core   +2 more sources