Results 51 to 60 of about 12,839 (218)

A Comparison for Type 2 Cytokines and Lesional Inflammatory Infiltrations in Bullous Pemphigoid and Atopic Dermatitis

Clinical, Cosmetic and Investigational Dermatology, 2022
Yu-qing Hu, Jian-zhong Zhang Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic ChinaCorrespondence: Jian-zhong Zhang, Tel +86-10-88325472, Fax +86-10-68318386, Email rmzjz@126.comBackground: Bullous pemphigoid (BP)
Hu YQ, Zhang JZ
doaj  

Inhibition of Virus-Induced Cytokine Production from Airway Epithelial Cells by the Late Addition of Budesonide

Medicina, 2020
Background: Viral infection is the main cause of asthma and COPD (chronic obstructive pulmonary disease) exacerbation and accumulate inflammatory cells to airway tissue.
Tetsuya Homma, Yosuke Fukuda, Yoshitaka Uchida, Tomoki Uno, Megumi Jinno, Yasunari Kishino, Mayumi Yamamoto, Hiroki Sato, Kaho Akimoto, Keisuke Kaneko, Akiko Fujiwara, Haruna Sato, Kuniaki Hirai, Yoshito Miyata, Hideki Inoue, Shin Ohta, Yoshio Watanabe, Sojiro Kusumoto, Koichi Ando, Shintaro Suzuki, Toshimitsu Yamaoka, Akihiko Tanaka, Tohru Ohmori, Hironori Sagara   +23 more
doaj   +1 more source

Thymic stromal lymphopoietin-stimulated CD4+ T cells induce senescence in advanced breast cancer

Frontiers in Cell and Developmental Biology, 2022
Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune response, commonly associated with atopic diseases. TSLP-activated CD4+ T helper 2 cells block early carcinogenesis by inducing terminal differentiation in spontaneous ...
Margherita Boieri, Margherita Boieri, Emanuela Marchese, Emanuela Marchese, Quan Minh Pham, Quan Minh Pham, Marjan Azin, Marjan Azin, Lauren E. Steidl, Lauren E. Steidl, Anna Malishkevich, Anna Malishkevich, Shadmehr Demehri, Shadmehr Demehri   +13 more
doaj   +1 more source

TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. [PDF]

, 2017
T follicular helper cells (Tfh) are important regulators of humoral responses. Human Tfh polarization pathways have been thus far associated with Th1 and Th17 polarization pathways. How human Tfh cells differentiate in Th2-skewed environments is unknown.
Alain Hovnanian, Alculumbre, Andrea Cavani, Andrea Chiricozzi, Ballesteros-Tato, Bernasconi, Bernhard Homey, Brandt, Briot, Bryant, Choi, Coline Trichot, Coquet, Crotty, Deenick, Elisabetta Volpe, Furio, Giacomin, Glatman Zaretsky, Gould, Grewe, Gringhuis, Hatzi, He, Hovnanian, Ito, Ito, Jacquemin, Kemeny, Kim, Kroenke, Kusam, Leyva-Castillo, Liang, Liu, Locci, Lonati, Lucia Pattarini, Ma, Ma, Marco Romanelli, Maximilien Grandclaudon, Melanie Durand, Morita, Nakazawa, Nies, Niu, O’Shea, Pène, Ramalingam, Schmitt, Schmitt, Schmitt, Shin, Sofia Bogiatzi, Soumelis, Stefania Madonna, Stephan Meller, Tangye, Toshiyuki Hori, Trinchieri, Ueno, Van Roey, Vassili Soumelis, Volpe, Volpe, Wang, Weinstein, Ying, Yusuf, Zela Keuylian, Ziegler   +71 more
core   +3 more sources

Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. [PDF]

, 2017
The epithelial and epidermal innate cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) have pivotal roles in the initiation of allergic inflammation in asthma and atopic dermatitis (AD).
Cheng, D, Di, H, Erle, DJ, Huo, X, Mo, Y, Shi, H, Xu, Y, Yi, L, Zhang, H, Zhang, K, Zhao, J, Zhen, G, Zou, Y   +12 more
core   +1 more source

Thymic Stromal Lymphopoietin Interferes with the Apoptosis of Human Skin Mast Cells by a Dual Strategy Involving STAT5/Mcl-1 and JNK/Bcl-xL [PDF]

, 2019
Mast cells (MCs) play critical roles in allergic and inflammatory reactions and contribute to multiple pathologies in the skin, in which they show increased numbers, which frequently correlates with severity. It remains ill-defined how MC accumulation is
Babina, Magda, Eberle, Jürgen, Hazzan, Tarek, Worm, Margitta   +3 more
core   +1 more source

Tezepelumab achieves improvement of severe uncontrolled asthma and rhinosinusitis: Case series

Journal of Allergy and Clinical Immunology: Global
Tezepelumab, a mAb targeting thymic stromal lymphopoietin (TSLP), reduces exacerbations in severe asthma. Four cases in which patients with severe asthma and chronic rhinosinusitis with nasal polyps showed improvements in both conditions after receiving ...
Shigesato Inoue, MD, Hiroaki Ogata, MD, PhD, Yoichi Dotake, MD, Koichi Takagi, MD, PhD, Ayaka Shiota, MD, Yumiko Ishii, MD, PhD, Kentaro Tanaka, MD, PhD, Keiko Kan-o, MD, PhD, Hiromasa Inoue, MD, PhD   +8 more
doaj   +1 more source

Az atópiás dermatitis patomechanizmusa [PDF]

, 2018
L
Steuer-Hajdu, Krisztina, Szegedi, Andrea
core   +1 more source

Early and Sustained Improvements in Sense of Smell With Tezepelumab Treatment in Patients With Chronic Rhinosinusitis With Nasal Polyps (WAYPOINT)

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health‐related quality of life and posing a safety hazard. Methods WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo ...
Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose   +14 more
wiley   +1 more source

TSLP Expression: Cellular Sources, Triggers, and Regulatory Mechanisms

Allergology International, 2012
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine initially identified in the culture supernatant of a thymic stromal cell line. Highly expressed in the epidermis in skin lesions of atopic dermatitis patients, TSLP was subsequently found to be
Toshiro Takai
doaj   +1 more source