Results 71 to 80 of about 12,710 (220)

Dupilumab Beyond the Airway: Decreased Morbidity in a Real‐World Analysis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Post hoc analyses of clinical trials have characterized dupilumab's adverse effects, yet the real‐world impact in chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma is not well described. This study aims to characterize the risks of lymphoma, cardiovascular events, eosinophilia, joint pain, inflammatory arthritis, and ...
Emma J. Anisman, Spencer Short, Emma Tam, Benjamin F. Bitner, Abdulghafoor Alani, Marc Rosen, Mindy Rabinowitz, Damaris Pena Evertz, Elina Toskala, Gurston G. Nyquist   +9 more
wiley   +1 more source

Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis.
Abdalla Sheikh, Abdalla Sheikh, Ninan Abraham, Ninan Abraham, Ninan Abraham   +4 more
doaj   +1 more source

Development of an analytical method for detecting triterpene alcohols in camellia oil and evaluation of their anti‐inflammatory effects

JSFA reports, EarlyView.
Abstract Background Camellia oil is a characteristic Chinese plant oil and is hailed as “the olive oil of the East”. However, there is a significant difference in the active ingredient between it and olive oil, which consequently leads to different effects.
Hengguang Cheng, Qing Jiang, Xiaoxia Li, Yunjie Jiang, Tinghuan Fang, Lirong Tang   +5 more
wiley   +1 more source

TSLP/dendritic cell axis promotes CD4+ T cell tolerance to the gut microbiome

JCI Insight, 2023
Thymic stromal lymphopoietin (TSLP) overexpression is widely associated with atopy. However, TSLP is expressed in normal barrier organs, suggesting a homeostatic function.
Jonathan L. Messerschmidt, Marjan Azin, Kaitlin E. Dempsey, Shadmehr Demehri   +3 more
doaj   +1 more source

Expression of Thymic Stromal Lymphopoietin in Immune-Related Dermatoses

Mediators of Inflammation, 2022
Thymic stromal lymphopoietin (TSLP), long known to be involved in Th2 response, is also implicated in multiple inflammatory dermatoses and cancers. The purpose of this study was to improve our understanding of the expression of TSLP in the skin of those ...
Si-Zhe Li, Xin-Xing Jin, Yin Shan, Hong-Zhong Jin, Ya-Gang Zuo   +4 more
doaj   +1 more source

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation [PDF]

, 2016
Additional file 2: Table S2. Primary and secondary antibodies used during western blot analysis of lung homogenate samples. All primary antibodies were diluted in TBS-T with 5 % BSA, while the secondary antibody was diluted in TBS-T with 5 ...
Akbarshahi, Hamid,, Brandelius, Angelica,, Lund University., Mahmutovic Persson, Irma,, Menzel, Mandy,, Uller, Lena,   +5 more
core   +4 more sources

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis [PDF]

Human Reproduction, 2012
Is thymic stromal lymphopoietin (TSLP) involved in the pathophysiology of endometriosis?TSLP is up-regulated by interleukin (IL)-1β and may be involved in the development of endometriosis.Endometriosis is a chronic inflammatory disease in which the Th2 immune response is activated and has been suggested to promote the disease. TSLP is a master cytokine
Yoko, Urata, Yutaka, Osuga, Gentaro, Izumi, Masashi, Takamura, Kaori, Koga, Miwako, Nagai, Miyuki, Harada, Tetsuya, Hirata, Yasushi, Hirota, Osamu, Yoshino, Yuji, Taketani   +10 more
openaire   +2 more sources

Dendritic Cell-Derived TSLP Negatively Regulates HIF-1α and IL-1β During Dectin-1 Signaling

Frontiers in Immunology, 2019
Thymic stromal lymphopoietin (TSLP) is a functionally pleotropic cytokine important in immune regulation, and TSLP dysregulation is associated with numerous diseases.
Matthew J. Elder, Matthew J. Elder, Steve J. Webster, Steve J. Webster, Timothy J. Fitzmaurice, Aran S. D. Shaunak, Martin Steinmetz, Ronnie Chee, Ziad Mallat, E. Suzanne Cohen, David L. Williams, J. S. Hill Gaston, Jane C. Goodall   +12 more
doaj   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source