Results 81 to 90 of about 12,839 (218)

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis. [PDF]

, 2019
Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Barton, Gregory M, Bautista, Diana M, Brem, Rachel B, Brock, Emily C, Deguine, Jacques, Gronert, Karsten, Hill, Rose Z, Kucirek, Natalie, Rifi, Ziad, Schwendinger-Schreck, Jamie, Walsh, Carolyn M, Wei, Jessica   +11 more
core   +1 more source

TSLP promoting B cell proliferation and polarizing follicular helper T cell as a therapeutic target in IgG4-related disease

Journal of Translational Medicine, 2022
Objective To figure out the functions of thymic stromal lymphopoietin (TSLP) in IgG4-related disease (IgG4-RD). Methods Plasma TSLP levels were tested by Elisa, and its receptors were detected by flow cytometry.
Hui Lu, Xunyao Wu, Yu Peng, Ruijie Sun, Yuxue Nie, Jingna Li, Mu Wang, Yaping Luo, Linyi Peng, Yunyun Fei, Jiaxin Zhou, Wen Zhang, Xiaofeng Zeng   +12 more
doaj   +1 more source

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Sensitizer‐Induced Basophils Accelerate Skin Re‐Epithelialization via IL‐4/IL‐13‐Mediated Macrophage Polarization

Allergy, EarlyView.
Oxazolone exposure drives rapid basophil recruitment to wounded skin, accelerating re‐epithelialization, angiogenesis, and tissue regeneration. Basophils are the dominant early source of IL‐4 and IL‐13 in the wound microenvironment. Basophil‐derived IL‐4/IL‐13 promote macrophage polarization toward a pro‐repair M2 phenotype, enabling efficient wound ...
Yufei Zhang, Xueting Peng, Kaixuan Ren, Shiran Kang, Zihan Xue, Yazhuo Li, Zhu Yan, Rongfang Feng, Min Gao, Qin Chen, Xiaoying Ning, Fan Bai, Liesu Meng, Yumin Xia, Yale Liu   +14 more
wiley   +1 more source

Correction: Corrigendum: Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma [PDF]

Mucosal Immunology, 2012
Correction to: Mucosal Immunology 2012; 5: 342–351; doi: 10.1038/mi.2012.14 The Asthma and Allergy Foundation of America was a funding source for these studies. The authors regret that this information was missing from the article.
H Han, W Xu, M B Headley, H K Jessup, K S Lee, M Omori, M R Comeau, A Marshak-Rothstein, S F Ziegler   +8 more
openaire   +1 more source

Targeting thymic stromal lymphopoietin in nasal type 2 inflammation

Eye & ENT Research
Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic ...
Xintong Li, Jingjing Guo, Jing Song, Ming Wang   +3 more
doaj   +1 more source

Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation [PDF]

, 2016
Additional file 2: Table S2. Primary and secondary antibodies used during western blot analysis of lung homogenate samples. All primary antibodies were diluted in TBS-T with 5 % BSA, while the secondary antibody was diluted in TBS-T with 5 ...
Akbarshahi, Hamid,, Brandelius, Angelica,, Lund University., Mahmutovic Persson, Irma,, Menzel, Mandy,, Uller, Lena,   +5 more
core   +4 more sources

Chinese Position Paper on Biologic Therapy for Allergic Rhinitis

Allergy, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a common, persistent nasal disorder that poses significant public health challenges worldwide. Current treatment options frequently fail to achieve adequate symptom control in a substantial subset of patients. Over the past two decades, biologic therapies that target type 2 inflammatory pathways have been used to ...
Yuan Zhang, Jingyun Li, Xian Li, Menglin Wang, Xiangli Yang, Li Shi, Zhiwei Cao, Yan Feng, Weiwei Liu, Zhendong Xu, Ruixia Ma, Xiaoping Gao, Wen Liu, Jinmei Xue, Xiaoyong Ren, Xuezhong Li, Xicheng Song, Yi Yang, Fang Quan, Lei Cheng, Weihong Jiang, Huabin Li, Jian Li, Huanhai Liu, Jianfeng Liu, Zheng Liu, Wei Lv, Qianhui Qiu, Xiangdong Wang, Yu Xu, Yuanteng Xu, Qintai Yang, Yucheng Yang, Jing Ye, Hongmeng Yu, Dongdong Zhu, Chengshuo Wang, Luo Zhang   +37 more
wiley   +1 more source

Thymic stromal lymphopoietin in leukemia: A double-edged sword?

Leukemia Research Reports
Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by various cell types. It is involved in the development of allergies, autoimmune diseases, and cancers.
Xing Zou, Mengmeng Gu, Yue Su, Dayong Yao, Hao Gang, Yang Li, Ce Shi   +6 more
doaj   +1 more source