Results 171 to 180 of about 199,261 (304)

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

A DNP‐Supported Solid‐State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine‐Stabilized Hoogsteen Structures in Mitochondria

Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.
Mitochondria are vital for energy production and rely on intricate nucleic acid structures to regulate gene expression. Using DNP‐ssNMR (dynamic nuclear polarization solid‐state NMR), we observed G‐quadruplex formation in intact mitochondria treated with berberine.
Michaela Dzurov Krafčíková, David Beriashvili, Salima Bahri, Menno Bergmeijer, Stuart C. Howes, Andrei Gurinov, Friedrich G. Förster, Gert E. Folkers, Marc Baldus   +8 more
wiley   +2 more sources

The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types. [PDF]

PLoS Biol
Trouth A, Ravichandran K, Gafken PR, Martire S, Boyle GE, Veronezi GMB, La V, Namciu SJ, Banaszynski LA, Sarthy JF, Ramachandran S.   +10 more
europepmc   +1 more source

In Vitro Structure–Activity Relationship Stability Study of Antisense Oligonucleotide Therapeutics Using Biological Matrices and Nucleases

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT The primary degradation pathway for antisense oligonucleotides (ASOs) involves endonuclease and exonuclease‐mediated breakdown. The effect of various chemical modifications on the stability of oligonucleotides has not been systematically investigated.
Jelena Lovrić, Jingjing Yan, XueQing Li, Tony Karlsborn, Mattias Bood, Anders Dahlén, Constanze Hilgendorf, Deepak Kumar Bhatt   +7 more
wiley   +1 more source

Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy. [PDF]

Front Immunol
Huang B, Yuan Q, Sun J, Wang C, Yang D.
europepmc   +1 more source

Activities of Thymidine Kinase and Thymine Deoxyribonucleotide Phosphatase during Growth of Cells in Tissue Culture

, 1965
Per Eker
openalex   +1 more source

Uptake and Incorporation of Thymine, Thymidine, Uracil, Uridine, and 5-Fluorouracil into the Nucleic Acids of Bacillus subtilis [PDF]

, 1965
Walter F. Bodmer, Susan Grether
openalex   +1 more source

Integrated Analysis of Gene Expression, Protein Synthesis, and Epigenetic Modifications in Alcanivorax borkumensis SK2 Under Iron Limitation

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Summarised transcriptomics, methylomics, and proteomics data plotted to circular maps using Circos software. Meanings of circles and histograms on the plots are explained in the figure legend. ABSTRACT This study aimed to understand the genetic and molecular mechanisms enabling Alcanivorax borkumensis SK2, a hydrocarbonoclastic marine bacterium, to ...
Francesco Smedile, Renata Denaro, Francesca Crisafi, Domenico Giosa, Giuseppe D'Auria, Manuel Ferrer, Riccardo Rosselli, Martin S. Staege, Michail M. Yakimov, Laura Giuliano, Oleg N. Reva   +10 more
wiley   +1 more source

Facile post-synthesis of isomeric covalent organic frameworks <i>via</i> precise pore surface engineering. [PDF]

Chem Sci
Liu Y, Chen Y, Shi K, Peng H, Lu C.
europepmc   +1 more source

Duration of the Mitotic Cycle in two Cultivars ofTriticum Durumas Measured by³H-Thymidine Labelling [PDF]

, 1969
S. Avanzi, Paolo Deri
openalex   +1 more source