Results 191 to 200 of about 127,095 (220)
Some of the next articles are maybe not open access.
Mitochondrial Thymidine Kinase Inhibitors
Current Topics in Medicinal Chemistry, 2005Mitochondrial thymidine kinase or TK-2 belongs to the family of mammalian deoxynucleoside kinases (dNKs) that catalyze the phosphorylation of deoxynucleosides to their corresponding deoxynucleoside monophosphates by gamma-phosphoryl transfer of ATP.
María-Jesús, Pérez-Pérez +6 more
openaire +2 more sources
Cancer, 1980
This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
D S, Martin +6 more
openaire +2 more sources
This review summarizes a body of information suggesting that proper metabolic modulation with certain metabolites can sensitize tumor cells to anti-metabolites, and others can de-sensitize (i.e. protect) normal cells from the toxicity of anti-metabolites.
D S, Martin +6 more
openaire +2 more sources
Nucleosides, Nucleotides and Nucleic Acids, 2006
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
openaire +2 more sources
Twenty-six fully sequenced archaeal genomes were searched for genes coding for putative deoxyribonucleoside kinases (dNKs). We identified only 5 human-like thymidine kinase 1 genes (TK1s) and none for non-TK1 kinases. Four TK1s were identified in the Euryarchaea and one was found in the Crenarchaea, while none was found in Nanoarchaeum.
A R, Clausen +3 more
openaire +2 more sources
Chemische Berichte, 1960
AbstractDie Kondensation von Monoquecksilberthymin mit Di‐p‐toluyl‐desoxy‐D‐ribofuranosylchlorid führt vorwiegend zum α‐Thymidinderivat, wenn man sie in stark polaren Verdünnungsmitteln wie Dimethylformamid ausführt. Daß es sich nicht um eine Kondensation am N‐3 des Thymins handelt, kann durch Methylierung des Produktes am N‐3 gezeigt werden.
openaire +1 more source
AbstractDie Kondensation von Monoquecksilberthymin mit Di‐p‐toluyl‐desoxy‐D‐ribofuranosylchlorid führt vorwiegend zum α‐Thymidinderivat, wenn man sie in stark polaren Verdünnungsmitteln wie Dimethylformamid ausführt. Daß es sich nicht um eine Kondensation am N‐3 des Thymins handelt, kann durch Methylierung des Produktes am N‐3 gezeigt werden.
openaire +1 more source
Radiation effects of thymidine-3H and thymidine-14C
Experimental Cell Research, 1960Results are reported from a comparative study of the fequencies of chromosome aberrations induced by tritiumgroup and in the number two position of the pyrimidine ring, C/sup 14/ in the methyl group produced twice as many abberations as C/sup 14/ in the pyrimidine ring. (auth)
H.A. McQuade, M. Friedkin
openaire +1 more source