Results 201 to 210 of about 151,356 (287)

¹⁹F NMR Functional Screening on a Benchtop NMR Instrument: Theoretical Analysis and Efficient Application to Drug Discovery. [PDF]

Anal Chem
Jordan C, Piotto M, Loss S, Dalvit C, Gossert AD.   +4 more
europepmc   +1 more source

Human Absorption, Metabolism, and Excretion (hAME) Mass Balance Studies in Patients With Cancer

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Radiolabeled mass balance human studies are a critical component of clinical pharmacology programs supporting the development of new investigational drugs. These studies provide information about absorption, metabolism, and excretion (AME) of the parent drug and metabolite(s) in the human body and are normally conducted in healthy volunteers ...
Begoña de las Heras, Claudine Oelke, Pamela Atwell, Hector Herrero, Paulo Nunes, Kamal S. Saini, Laura Vidal Boixader, Catherine Laing, James Bush, Emiliano Calvo   +9 more
wiley   +1 more source

Metabolic reconstruction reveals ATP salvage as a key response to trimethoprim treatment. [PDF]

iScience
Carter C, Singh D, Wain J, Langridge GC.
europepmc   +1 more source

Proteomic Profiling of Plasma to Uncover Novel Intervention Targets and Prognostic Biomarkers for Chronic Liver Diseases

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5029-5042, June 2026.
ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li, Jing Sun, Jianhui Zhao, Fangyuan Jiang, Meng Zhang, Hao Wu, Shuai Yuan, Xue Li, Juan Lu, Christos S. Mantzoros   +9 more
wiley   +1 more source

Chemical Synthesis of Native ADP-Ribosylated Oligonucleotides Enables Analysis of DNA ADP-Ribosylation Hydrolase Specificity. [PDF]

J Am Chem Soc
Tang L, Lu Y, van der Heijden FLAM, Chen Y, Jiang S, Meeuwenoord NJ, Liu L, Yu Z, Chen Z, Schuller M, Filippov DV, Ahel I, Liu Q.   +12 more
europepmc   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, Volume 293, Issue 11, Page 3166-3186, June 2026.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Cyclic di-AMP inhibits <i>Listeria monocytogenes</i> thymineless death during infection. [PDF]

mBio
Leeming JP, Elkassih OM, Oyebode DT, Woodward JJ, Tang Q.   +4 more
europepmc   +1 more source

Gastroprotective Effects of Hexanic Extract of the Leaves of Spondias purpurea and Its Underlying Mechanism of Action

Journal of Food Process Engineering, Volume 49, Issue 6, June 2026.
Histopathological analysis of gastric mucosa stained with HE and PAS of rats submitted to induction of ulcers with acetic acid. The animals were treated orally with vehicle (injured control), ranitidine, and SpHE (25 mg/kg) for 14 days. In A and B, observe preserved mucosa and submucosal layers (black asterisk) and presence of the barrier protection of
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Alves Bandeira Alves Costa, Caroline Leal Rodrigues Soares, Natalie Emanuelle Ribeiro Rodrigues, Vanda Lucia dos Santos, Almir Gonçalves Wanderley, Henrique D. M. Coutinho, Teresinha Gonçalves da Silva   +9 more
wiley   +1 more source

Author Correction: Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotency. [PDF]

Exp Mol Med
Kim HK, Song Y, Kye M, Yu B, Choi HK, Moon SH, Lee MR.   +6 more
europepmc   +1 more source

Losing genes, gaining edits: how relaxed selection and inverted repeat expansion shape RNA editing in Schizaeaceae plastomes

The Plant Journal, Volume 126, Issue 5, June 2026.
SUMMARY RNA editing is a post‐transcriptional pyrimidine exchange process that alters plastid and mitochondrial transcripts in nearly all land plants. Although confined to organelles, it is directed by nuclear‐encoded PLS‐type pentatricopeptide repeat (PPR) proteins, each typically recognizing a specific RNA target.
Blake D. Fauskee, Li‐Yaung Kuo, Farley Kwok van der Giezen, Kathleen M. Pryer   +3 more
wiley   +1 more source