Results 31 to 40 of about 312,982 (289)
PLoS ONE, 2021 Adult growth hormone deficiency (GHD), a condition characterized by increased oxidative stress, is related to augmented cardiovascular, metabolic and oncological risk. A case-control observational study has been performed to evaluate DNA oxidative damage
Antonio Mancini +8 more
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EFFECTS OF INTESTINALLY ABSORBED THYMIDINE ON TRITIATED THYMIDINE UTILIZATION
Cell Proliferation, 1979 ABSTRACTExperimental evidence presented suggests that [3H]TdR can be rapidly and efficiently transported from the intestine to the systemic circulation. This pathway for thymidine transport may be physiologically important since administration of cold thymidine in the drinking water enhances the utilization of a parenterally injected dose of [3H]TdR in
R P, Williams, I L, Cameron, E K, Adrian
openaire +2 more sources
Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]
, 2015 Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A +17 more
core +2 more sources
Hydrogen Peroxide-Induced Thymidine Incorporation Into Cultured Rat Astrocytes
Journal of Pharmacological Sciences, 2006 We characterized [methyl-3H]thymidine ([3H]thymidine) and [5-3H]uridine ([3H]uridine) incorporation into cultured astrocytes and neurons in the presence and absence of hydrogen peroxide (H2O2) in order to define the response to oxidative stress in the ...
Koh-ichi Tanaka +3 more
doaj +1 more source
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil [PDF]
, 1968 With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo ...
Shigehisa, Morio
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Erythrocyte encapsulated thymidine phosphorylase is recombinant Escherichia coli thymidine phosphorylase encapsulated within human autologous erythrocytes and is under development as an enzyme replacement therapy for the ultra-rare inherited metabolic ...
Michelle Levene +5 more
doaj +1 more source
Inhibitory Effect of Bridged Nucleosides on Thermus aquaticus DNA Polymerase and Insight into the Binding Interactions. [PDF]
PLoS ONE, 2016 Modified nucleosides have the potential to inhibit DNA polymerases for the treatment of viral infections and cancer. With the hope of developing potent drug candidates by the modification of the 2',4'-position of the ribose with the inclusion of a bridge,
Sung-Kun Kim +5 more
doaj +1 more source
Frontiers in Pediatrics, 2022 BackgroundPatients with T cell deficiency <10% of normal proliferation are indicated to receive immune reconstruction by hematopoietic stem cell transplantation (HSCT).
Hsin-Ju Lee +13 more
doaj +1 more source
Acta Societatis Botanicorum Poloniae, 2015 Hydroxyurea treatment of onion roots induced mitotic block which was released by transfer of bulbs to water, and also to some extent by addition of cold or 3H-thymidine to hydroxyurea solutions.
H. Habdas
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PLoS ONE, 2020 Bacterial production has been often estimated from DNA synthesis rates by using tritium-labeled thymidine. Some bacteria species cannot incorporate extracellular thymidine into their DNA, suggesting their biomass production might be overlooked when using
Kenji Tsuchiya +8 more
doaj +1 more source