Results 41 to 50 of about 199,261 (304)
Frontiers in Cellular and Infection Microbiology, 2017 Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can ...
Irene Rodríguez-Arce +20 more
doaj +1 more source
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
Journal of Neuroscience, 2000 Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect of antidepressants on hippocampal neurogenesis in the adult rat ...
J. Malberg +3 more
semanticscholar +1 more source
Nature, 1968 Thymidine Metabolism and Cell Kinetics By J. E. Cleaver. (North-Holland Research Monographs: Frontiers of Biology. Vol. 6.) Pp. 259. (Amsterdam: North-Holland Publishing Company, 1967.) 86s.
openaire +2 more sources
Advances in Hematology, 2011 Thymidine phosphorylase may be overexpressed in both neoplastic cells and tumor stromal cells in a variety of malignancies. Our study explores thymidine phosphorylase expression in lymph nodes (LNs) from patients with mycosis fungoides (MF) or Sézary ...
Xingcao Nie +4 more
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Molecular Oncology, EarlyView.The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld +7 more
wiley +1 more source
The dual role of thymidine phosphorylase in cancer development and chemotherapy
Medicinal research reviews (Print), 2009 Thymidine phosphorylase (TP), also known as “platelet‐derived endothelial cell growth factor” (PD‐ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers. TP promotes tumor growth and metastasis
A. Bronckaers +3 more
semanticscholar +1 more source
A Dual‐Emissive DNA‐Templated Silver Nanocluster with Near‐Infrared I and II Emission
Advanced Optical Materials, Volume 13, Issue 8, March 13, 2025.This study presents a dual‐emissive DNA‐stabilized silver nanocluster with a nanosecond‐lived NIR‐I emission band and a microsecond‐lived NIR‐II emission band. Mass spectrometry establishes that the nanocluster has molecular formula (DNA)2[Ag17]11+. DNA sequence variations reveal critical nucleobases for stabilization, and modifications at the DNA 5 ...
Anna Gonzàlez‐Rosell +6 more
wiley +1 more source
The Scientific World Journal, 2012 5-fluorouracil (5-FU) is one of the most commonly used antineoplastic drugs in the anticancer therapy. The hand-foot (HF) syndrome (palmar-plantar erythrodysesthesia) is an adverse effect frequently related to long-term i.v. administration of 5-FU or its
J. Hartinger +5 more
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Pharmacogenetic variation influences sensory neuropathy occurrence in Southern Africans treated with stavudine-containing antiretroviral therapy. [PDF]
PLoS ONE, 2018 BACKGROUND:The use of the HIV antiretroviral drug stavudine (d4T), a thymidine analogue, is associated with the development of mitochondrial toxicities such as sensory neuropathy (SN).
Marvin Blessings Moketla +3 more
doaj +1 more source
IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation
Advanced Science, EarlyView.LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu +10 more
wiley +1 more source