Structural Basis for the Dual Thymidine and Thymidylate Kinase Activity of Herpes Thymidine Kinases [PDF]
Structure, 2003 Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined ...
Gardberg, A. +4 more
openaire +5 more sources
Thymidine Kinase+/− Mammalian Cell Mutagenicity Assays for Assessment of Nanomaterials [PDF]
Frontiers in Toxicology, 2022 Graphical ...
Tao Chen +2 more
doaj +2 more sources
Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dogs [PDF]
Journal of Veterinary Internal MedicineBackground Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in‐house method has not been established.
Yoonhee Kim +12 more
doaj +2 more sources
INDUCIBILITY OF THYMIDINE KINASE BY THYMIDINE AS A FUNCTION OF INTERPHASE STAGE [PDF]
Journal of Cell Biology, 1965 Thymidine may act as an inducer of thymidine kinase activity in cells of higher plants. The general response is demonstrable in a randomly developing cell population such as is found in germinating wheat embryos. If a synchronously developing cell population is studied, however, potentially inducible cells are found to be susceptible to the inductive ...
Yasuo Hotta +2 more
exaly +3 more sources
Predictive levels of vascular endothelial growth factor (VEGF), thymidine kinase 1 (TK1) with interleukin-6 (IL-6), plasma T cells, NK cells as well as B cells in treating diffuse large B-cell lymphoma receiving rituximab [PDF]
Journal of Medical BiochemistryBackground: The aim was to explore the effect of rituximab in combination with chemotherapy in treating diffuse large B-cell lymphoma and levels of vascular endothelial growth factor (VEGF), thymidine kinase 1(TK1) with interleukin-6 (IL-6), plasma T ...
Tian Lihua +3 more
doaj +2 more sources
Optimization of Thymidine Kinase-Based Safety Switch for Neural Cell Therapy [PDF]
Cells, 2022 Cell therapies based on pluripotent stem cells (PSC), have opened new therapeutic strategies for neurodegenerative diseases. However, insufficiently differentiated PSC can lead to tumor formation.
Manon Locatelli +7 more
doaj +2 more sources
Increased levels of thymidine kinase 1 in malignant cell-derived extracellular vesicles [PDF]
Biochemistry and Biophysics ReportsExtracellular vesicles (EVs), whose main subtypes are exosomes, microparticles, and apoptotic bodies, are secreted by all cells and harbor biomolecules such as DNA, RNA, and proteins.
Ehsan Manouchehri Doulabi +7 more
doaj +2 more sources
Validation of a novel HPLC-based serum thymidine kinase assay for breast cancer detection [PDF]
BioDiscovery, 2017 Validation of a novel HPLC-based serum thymidine kinase assay for breast cancer ...
Elena Kuzmanova +3 more
doaj +5 more sources
Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complex for the viability in response to the anti-cancer drug 5-fluorodeoxyuridine. [PDF]
PLoS ONE, 2017 Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causes disruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim +5 more
doaj +1 more source
Putting drug resistant epithelial herpes keratitis in the spotlight: A case series
American Journal of Ophthalmology Case Reports, 2022 Purpose: To strengthen the sparse evidence on acyclovir (ACV) resistance, especially in recalcitrant herpetic keratitis (HK), by describing the clinical course of 3 genotypically proven ACV resistant HK cases.
Ivo De Clerck +6 more
doaj +1 more source