Results 11 to 20 of about 61,976 (190)
Tk-deleted pseudorabies virus retains high pathogenicity in rats
Journal of Veterinary Research, 2021 The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion.
Zhang Lirong +11 more
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Mitochondrial DNA Depletion Syndrome
Pediatric Neurology Briefs, 2002 Twenty patients with myopathic mitochondrial DNA (mtDNA) depletion syndrome (MDS) were screened for mutations in thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) genes at Columbia University, New York, NY.
J Gordon Millichap
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Molecular Therapy: Oncolytics, 2017 Multiple myeloma is a malignancy of plasma cells of the bone marrow. Although the prognosis is variable, no curative therapy has been defined. Vaccinia virus infects cancer cells and kills such cells in a variety of ways.
Muneyoshi Futami +5 more
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Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
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Disorders of purines and pyrimidines metabolism in human gastrointestinal tract cancer
Current Issues in Pharmacy and Medical Sciences, 2013 Patients with cancer of stomach, colon cancer and rectum showed an increase in the thymidine kinase, 5'–nucleotidase of adenylate, adenosine deaminase activities and a decrease in the thymidine phosphorylase activity, which can cause DNA biosynthesis ...
Berta Borzenko +2 more
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Molecular Therapy: Oncolytics, 2019 Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe +9 more
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Structural Basis for the Dual Thymidine and Thymidylate Kinase Activity of Herpes Thymidine Kinases [PDF]
Structure, 2003 Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined ...
Gardberg, A. +4 more
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BMC Neuroscience, 2022 Background Deoxythymidine triphosphate (dTTP) is an essential building block of DNA, and defects in enzymes involved in dTTP synthesis cause neurodegenerative disorders.
Junmei Hu Frisk +4 more
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Molecular Therapy: Oncolytics, 2016 Tunneling nanotubes (TNTs) are ultrafine, filamentous actin-based cytoplasmic extensions which form spontaneously to connect cells at short and long-range distances.
Justin Ady +7 more
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Thymidine kinase in breast cancer [PDF]
British Journal of Cancer, 1990 The enzyme thymidine kinase is associated with DNA synthesis. Thymidine kinase serum levels were studied in normal controls (n = 20), patients with primary breast cancer (n = 60), patients with systemic breast cancer (n = 20) and as a non-cancer disease control group in patients with inflammatory gastrointestinal disorders (n = 20).
J F, Robertson +4 more
openaire +2 more sources