Results 41 to 50 of about 107,915 (237)
Concentration of human thymidine kinase 1 discover invisible malignant human tumours
European Journal of Cell Biology, 2022 Early discover of risk progression of invisible carcinomas is important for a prerequisite successful treatment. Here, we investigated whether concentration of human thymidine kinase 1 (HTK1) discover invisible malignant human tumours.
Ji Zhou +10 more
doaj +1 more source
Structural Basis for the Dual Thymidine and Thymidylate Kinase Activity of Herpes Thymidine Kinases [PDF]
Structure, 2003 Crystal structures of equine herpesvirus type-4 thymidine kinase (EHV4-TK) in complex with (i). thymidine and ADP, (ii). thymidine and SO(4) and the bisubstrate analogs, (iii). TP(4)A, and (iv). TP(5)A have been solved. Additionally, the structure of herpes simplex virus type-1 thymidine kinase (HSV1-TK) in complex with TP(5)A has been determined ...
Gardberg, A. +4 more
openaire +3 more sources
UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
core +1 more source
Journal of Experimental Life Science, 2018 Koi herpesvirus (KHV) is a virus that usually infects carp and koi causing mass mortality, as well as economic and social loss. The results of varied test are often found in its development.
Amira Baihani +2 more
doaj +1 more source
Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. [PDF]
PLoS ONE, 2011 BACKGROUND: The maintenance of the intestinal epithelium is of great importance for the survival of the organism. A possible nervous control of epithelial cell renewal was studied in rats and mice.
Ove Lundgren +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. [PDF]
PLoS ONE, 2013 Non-invasive imaging biomarkers of cellular proliferation hold great promise for quantifying response to personalized medicine in oncology. An emerging approach to assess tumor proliferation utilizes the positron emission tomography (PET) tracer 3'-deoxy-
Eliot T McKinley +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
In silico investigation of acyclovir derivatives potency against herpes simplex virus
Scientific African, 2023 Herpes simplex virus (HSV) is a major human pathogen, sub-divided into two types: HSV-1 which causes oral and perioral infections and HSV-2 which causes genital herpes.
Clive M. Nyaribo +2 more
doaj +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source