Results 21 to 30 of about 67,342 (249)
Thymidine plaque autoradiography of thymidine kinase-positive and thymidine kinase-negative herpesviruses [PDF]
Journal of Clinical Microbiology, 1983 Plaques formed by herpes simplex virus (HSV), pseudorabies virus, and varicella-zoster virus were studied by plaque autoradiography after [14C]thymidine labeling. Standard thymidine kinase-positive (TK+) viruses and TK- mutants of HSV types 1 and 2 and pseudorabies virus were studied, including cell cultured viruses and viruses isolated from animals ...
R B, Tenser +3 more
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Clinical Case Reports, 2021 Adenovirus‐mediated herpes simplex virus thymidine kinase gene therapy (ADV‐TK) in combination with interventional treatment could relieve the symptoms in patients with widespread splenic metastasis.
Qing Liu +5 more
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Tk-deleted pseudorabies virus retains high pathogenicity in rats
Journal of Veterinary Research, 2021 The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion.
Zhang Lirong +11 more
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, 2023 Metabolic chemical probes are small-molecule reagents that utilize naturally occurring biosynthetic enzymes for in situ incorporation into biomolecules of interest.
Hilko, David +4 more
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Mitochondrial DNA Depletion Syndrome
Pediatric Neurology Briefs, 2002 Twenty patients with myopathic mitochondrial DNA (mtDNA) depletion syndrome (MDS) were screened for mutations in thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) genes at Columbia University, New York, NY.
J Gordon Millichap
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Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. [PDF]
PLoS ONE, 2018 INTRODUCTION:Successful inhibition of thymidylate synthase (TS) by pemetrexed, a TS inhibitor, results in a reproducible transient burst or "flare" in thymidine salvage pathway activity at 2 hrs.
Xiao Chen, Yizeng Yang, Sharyn I Katz
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Molecular Therapy: Oncolytics, 2017 Multiple myeloma is a malignancy of plasma cells of the bone marrow. Although the prognosis is variable, no curative therapy has been defined. Vaccinia virus infects cancer cells and kills such cells in a variety of ways.
Muneyoshi Futami +5 more
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Molecular Therapy: Oncolytics, 2019 Oncolytic vaccinia viruses are currently in clinical development. However, the safety and the tumor selectivity of these oncolytic viruses must be improved.
Johann Foloppe +9 more
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Thymidine kinase in breast cancer [PDF]
British Journal of Cancer, 1990 The enzyme thymidine kinase is associated with DNA synthesis. Thymidine kinase serum levels were studied in normal controls (n = 20), patients with primary breast cancer (n = 60), patients with systemic breast cancer (n = 20) and as a non-cancer disease control group in patients with inflammatory gastrointestinal disorders (n = 20).
J F, Robertson +4 more
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Crystal Structures of T. b. rhodesiense Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation [PDF]
, 2011 Background: The essential purine salvage pathway of Trypanosoma brucei bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis.
Jason Greenwald +17 more
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