Results 21 to 30 of about 61,976 (190)

The diagnostic value of serum microRNA-183 and TK1 as biomarkers for colorectal cancer diagnosis

Open Life Sciences, 2017
To evaluate the serum levels of microRNA-183 (miR-183) and thymidine kinase 1 (TK1) in colorectal cancer patients and their clinical value as biomarkers for colorectal cancer auxiliary diagnosis.
Zhu Xiangrong, Wang Xiongtie, Chen Xihua
doaj   +1 more source

Serum Thymidine Kinase (TK) Evaluation in HIV Infection

The International Journal of Biological Markers, 1989
Serum thymidine kinase (TK), measured using Prolifigen TK-REA, from AB Sangtec Medical, was investigated in 24 HIV seropositive patients without immunological alterations, 26 seropositives with immunological alterations, 125 LAS, 25 ARC, and 20 AIDS ...
S. Sabbatani, A. Fini, E. Raise, F.M. Gritti   +3 more
doaj   +1 more source

Thymidine kinase 1 through the ages: a comprehensive review

Cell & Bioscience, 2020
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter, Michelle H. Townsend, Rachel Erickson, Carolyn Allen, Kim L. O’Neill   +4 more
doaj   +1 more source

Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions

Cardiovascular Diabetology, 2007
Background Inhibition of vascular smooth muscle cell (vSMC) proliferation by oral anti-hyperglycemic agents may have a role to play in the amelioration of vascular disease in diabetes.
de Dios Stephanie T, Osman Narin, Little Peter J, Cemerlang Nelly, Ballinger Mandy, Nigro Julie   +5 more
doaj   +1 more source

Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiencyResearch in context

EBioMedicine, 2019
Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway.
Carlos Lopez-Gomez, Henly Hewan, Carlos Sierra, Hasan O. Akman, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Saba Tadesse, Kurenai Tanji, Elisa E. Konofagou, Michio Hirano   +9 more
doaj   +1 more source

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major. [PDF]

PLoS Neglected Tropical Diseases, 2015
Leishmania spp. is a protozoan parasite and the causative agent of leishmaniasis. Thymidine kinase (TK) catalyses the transfer of the γ-phosphate of ATP to 2'-deoxythymidine (dThd) forming thymidine monophosphate (dTMP). L.
Jennifer Timm, Cristina Bosch-Navarrete, Eliseo Recio, Joanne E Nettleship, Heather Rada, Dolores González-Pacanowska, Keith S Wilson   +6 more
doaj   +1 more source

Bi-allelic Homology-Directed Repair with Helper-Dependent Adenoviruses

Molecular Therapy: Methods & Clinical Development, 2019
We describe a strategy to achieve footprintless bi-allelic homology-directed repair (HDR) using helper-dependent adenoviruses (HDAds). This approach utilizes two HDAds to deliver the donor DNA.
Donna J. Palmer, Dustin L. Turner, Philip Ng   +2 more
doaj   +1 more source

Concentration of human thymidine kinase 1 discover invisible malignant human tumours

European Journal of Cell Biology, 2022
Early discover of risk progression of invisible carcinomas is important for a prerequisite successful treatment. Here, we investigated whether concentration of human thymidine kinase 1 (HTK1) discover invisible malignant human tumours.
Ji Zhou, Huijun Li, Cong Fang, Peng Gao, Cuicui Jin, Sonbo Liu, Rougu Zou, Jin Li, Yougping Liu, Ellen He, Sven Skog   +10 more
doaj   +1 more source

Development of a Novel Recombinant Full-Length IgY Monoclonal Antibody against Human Thymidine Kinase 1 for Automatic Chemiluminescence Analysis on a Sandwich Biotin-Streptavidin Platform for Early Tumour Discovery

Journal of Immunology Research, 2023
Serum thymidine kinase 1 protein (STK1p) concentration has been used successfully as a reliable proliferating serum biomarker in early tumour discovery and clinical settings.
Xiangbin Wang, Shan Li, Rui Zhao, Huijun Li, Peng Gao, Cuicui Jin, Cong Fang, Yongping Liu, Ailian Hei, Ji Zhou, Jin Li, Ellen He, Sven Skog   +12 more
doaj   +1 more source

Thymidine Kinase in IDU Resistance.

Experimental Biology and Medicine, 1965
SummaryStudies were done to determine whether 5-iodo-2′-deoxyuridine resistance of herpes simplex in rabbit corneal infection was a function of thymidine kinase deficiency in the viral genome. Herpes simplex virus passed in rabbit kidney cells in the presence of 5-iodo-2′-deoxyuridine was resistant to it in vivo although this resistant virus induced ...
Y, Centifanto, H E, Kaufman
openaire   +2 more sources