Results 201 to 210 of about 62,555 (239)
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Thymidine kinase assay in canine lymphoma
Veterinary and Comparative Oncology, 2011The aim of the study was to evaluate if thymidine kinase (TK) correlated with duration of first remission (DFR) or survival in dogs with lymphoma and if initial TK levels correlated with stage and substage; and also to assess if TK level at diagnosis correlated with immunophenotype.
J. W. Elliott +2 more
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Characterization of the EBV Thymidine Kinase [PDF]
, 1987 Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis (IM) and has been shown chronically to infect immunocompromised hosts. Recently the nucleoside analogue acylovir (ACV) has been shown to have an anti-EBV effect both in vitro and in the treatment of IM patients (2,9).
J. R. Arrand, E. Littler
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1991
Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
Staffan Eriksson +3 more
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Deoxynucleoside kinases catalyze 5′-phosphorylation of deoxynucleosides and deoxynucleoside analogs used in chemotherapy. Cytosolic thymidine kinase (TK1), mitochondrial thymidine kinase (TK2) and cytosolic deoxycytidine kinase (dCK) are key enzymes in this metabolism.
Staffan Eriksson +3 more
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Characterization of the Thymidine Kinase of Physarum polycephalum
The Journal of Biochemistry, 1983Thymidine kinase [ATP: thymidine 5'-phosphotransferase, EC 2.7.1.21] has been purified more than 3,500 fold from microplasmodia of Physarum polycephalum. Properties of the enzyme were determined on preparations purified 1,400 fold. Thymidine was transformed to dTMP while a stoichiometric quantity of ATP was transformed to ADP.
Michel Wright, Rachid Chraibi
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The role of thymidine kinase in cancer diseases
Expert Opinion on Medical Diagnostics, 2008Thymidine kinase 1 (TK 1-fetal) is a cell cycle-dependent marker that increases dramatically during the S-phase of the cell cycle. In this review, the authors discuss serum levels of thymidine kinase in a variety of neoplasias. Determination of thymidine kinase helps to monitor the follow-up of solid tumours and haematological malignancies as well as ...
Lubos Holubec, Ondrej Topolcan
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Thymidine kinase in brain-tumor cysts
Journal of Neurosurgery, 1985✓ A recently developed method for deoxythymidine kinase (TK) determination was applied to brain-tumor cyst fluid and fluid from a non-neoplastic intracerebral cyst. The fluid from all tumors tested positive for TK whereas the non-neoplastic cyst lacked TK. Cyst fluid was also analyzed for TK before and after intracystic instillation of BCNU.
Claes Källander +4 more
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Serum thymidine kinase in colorectal neoplasia
European Journal of Surgical Oncology (EJSO), 1995Thymidine kinase (TK), an enzyme known to be associated with DNA synthesis, has been measured in the serum of patients with asymptomatic colorectal adenomas (n = 40), asymptomatic colorectal carcinoma (n = 21) and patients known to have hepatic metastases form colorectal tumours (n = 33); enzyme levels have been compared with an age-matched group of ...
W. M. Thomas +5 more
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Methotrexate decreases thymidine kinase activity
Biochemical and Biophysical Research Communications, 1992MTX cytotoxicity is not fully explained by its well-known inhibition of dihydrofolate reductase activity which leads to a decrease in the dTMP synthase reaction, since TdR kinase which converts TdR to dTMP could readily circumvent MTX action through this salvage activity.
Noemi Prajda +4 more
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Thymidine-kinase in cytomegalovirus infected cells
Archives of Virology, 1976In human diploid fibroblast LEP cells infected with AD169 strain of human cytomegalovirus (CMV) a sharp increase of cytosol thymidine kinase activity was observed. The properties of the cytosol enzymes from infected and non-infected cells were compared.
Vladimír Vonka +3 more
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Semisynthesis of human thymidine monophosphate kinase
Peptide Science, 2010AbstractProtein semisynthesis based on native chemical ligation has become a major protein engineering tool that allows manipulation of domains of proteins of all sizes. It helps to overcome limitations in chemical protein synthesis set by the inherent size limits of solid phase peptide synthesis.
Roger S. Goody +4 more
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