Results 81 to 90 of about 946,060 (233)

Activin A induces ovine follicle stimulating hormone beta using -169/-58 bp of its promoter and a simple TATA box

Reproductive Biology and Endocrinology, 2009
Background Activin A increases production of follicle stimulating hormone (FSH) by inducing transcription of its beta subunit (FSHB). This induction has been studied here in LbetaT2 gonadotropes using transient expression of ovine FSHBLuc (-4741 bp of ...
Miller William L, Han Sang-oh
doaj   +1 more source

A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography.

Proceedings of the National Academy of Sciences of the United States of America, 2000
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report here a method to improve the detection of lower levels of
S. Gambhir, Eileen Bauer, M. Black, Q. Liang, M. Kokoris, J. Barrio, M. Iyer, M. Namavari, M. Phelps, H. Herschman   +9 more
semanticscholar   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression

Molecular Therapy: Oncolytics, 2022
Glioblastoma multiforme (GBM) is the most invasive form of primary brain astrocytoma. Gene therapy using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) is a new strategy for GBM treatment.
Saereh Hosseindoost, Seyed Mojtaba Mousavi, Ahmad Reza Dehpour, Seyed Amirhossein Javadi, Babak Arjmand, Ali Fallah, Mahmoudreza Hadjighassem   +6 more
doaj  

Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Grey hair, a common ageing‐associated phenomenon in humans, is mainly attributed to the damage of melanocytes and the absence of melanin. Grey hair has long been treated with traditional medicine, and new research has shown that various plant‐derived monomers can increase tyrosinase activity and melanogenesis, indicating that they may have ...
Chengjie Wei, Xiaomin Hou, Xuelu Jiang, Ming Gao, Yan Gao, Lin Bi, Jisheng Nie, Liangyuan Zhao, Yiwei Shi, Xiaojiang Qin   +9 more
wiley   +1 more source

In silico investigation of acyclovir derivatives potency against herpes simplex virus

Scientific African, 2023
Herpes simplex virus (HSV) is a major human pathogen, sub-divided into two types: HSV-1 which causes oral and perioral infections and HSV-2 which causes genital herpes.
Clive M. Nyaribo, Florence A. Ng'ong'a, Steven G. Nyanjom   +2 more
doaj  

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

Neoplasia: An International Journal for Oncology Research, 1999
Current gene therapy technology is limited by the paucity of methodology for determining the location and magnitude of therapeutic transgene expression in vivo.
Andreas Jacobs, Michael Dubrovin, Jeff Hewett, Miguel Sena-Esteves, Cui-Wen Tan, Mark Slack, Michele Sadelain, Xandra O. Breakefield, Juri G. Tjuvajev   +8 more
doaj   +1 more source

Megalocytivirus: A Review of Epidemiology, Pathogenicity, Immune Evasion, and Prevention Strategies

Reviews in Aquaculture, Volume 17, Issue 3, June 2025.
ABSTRACT Megalocytivirus, a large double‐stranded DNA virus belonging to the Iridoviridae family, has infected over 100 species of fish, leading to significant economic losses in the aquaculture, food, and ornamental fish industries. These viruses exhibit icosahedral symmetry and have diameters ranging from 120 to 200 nm.
Changjun Guo, Jian He, Xiaopeng Xu, Shaoping Weng, Jianguo He   +4 more
wiley   +1 more source

Transcriptional effects of Organochlorine o,p′-DDT and its Metabolite p,p′-DDE in Transfected MDA-MB 231 and MCF-7 Breast Cancer Cell Lines

Research in Molecular Medicine, 2015
Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine ...
Ehsan zayerzadeh, Mohammad Kazem Koohi, Azadeh Fardipour   +2 more
doaj  

Beyond fluorodeoxyglucose: Molecular imaging of cancer in precision medicine

CA: A Cancer Journal for Clinicians, Volume 75, Issue 3, Page 226-242, May/June 2025.
Abstract Cancer molecular imaging is the noninvasive visualization of a process unique to or altered in neoplasia, such as proliferation, glucose metabolism, and receptor expression, which is relevant to patient management. Several molecular imaging modalities are now available, including magnetic resonance, optical, and nuclear imaging.
Malik E. Juweid, Soud F. Al‐Qasem, Fadlo R. Khuri, Andrea Gallamini, Philipp Lohmann, Hans‐Joachim Ziellenbach, Felix M. Mottaghy   +6 more
wiley   +1 more source