Results 81 to 90 of about 62,555 (239)

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

Neoplasia: An International Journal for Oncology Research, 1999
Current gene therapy technology is limited by the paucity of methodology for determining the location and magnitude of therapeutic transgene expression in vivo.
Andreas Jacobs, Michael Dubrovin, Jeff Hewett, Miguel Sena-Esteves, Cui-Wen Tan, Mark Slack, Michele Sadelain, Xandra O. Breakefield, Juri G. Tjuvajev   +8 more
doaj   +1 more source

Astrocyte in Neurological Disease: Pathogenesis and Therapy

MedComm, Volume 6, Issue 8, August 2025.
This review provides comprehensive overview of astrocytes in neurological disorders. Astrocytes contribute to neurological disorders via A1/A2 polarization, inducing neuroinflammation, synaptic, and BBB dysfunction. Metabolic disturbances in glucose, lipid, and amino acid pathways leading to oxidative stress and mitochondrial damage.
Meihui Huang, Aoyang Long, Lingjia Hao, Zilin Shi, Mengqi Zhang   +4 more
wiley   +1 more source

β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression

Molecular Therapy: Oncolytics, 2022
Glioblastoma multiforme (GBM) is the most invasive form of primary brain astrocytoma. Gene therapy using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) is a new strategy for GBM treatment.
Saereh Hosseindoost, Seyed Mojtaba Mousavi, Ahmad Reza Dehpour, Seyed Amirhossein Javadi, Babak Arjmand, Ali Fallah, Mahmoudreza Hadjighassem   +6 more
doaj  

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

Cancer Science, Volume 116, Issue 8, Page 2137-2149, August 2025.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu, Yuka Itoh, Tomoe Sawaguchi, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa   +6 more
wiley   +1 more source

Transcriptional effects of Organochlorine o,p′-DDT and its Metabolite p,p′-DDE in Transfected MDA-MB 231 and MCF-7 Breast Cancer Cell Lines

Research in Molecular Medicine, 2015
Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine ...
Ehsan zayerzadeh, Mohammad Kazem Koohi, Azadeh Fardipour   +2 more
doaj  

Activin A induces ovine follicle stimulating hormone beta using -169/-58 bp of its promoter and a simple TATA box

Reproductive Biology and Endocrinology, 2009
Background Activin A increases production of follicle stimulating hormone (FSH) by inducing transcription of its beta subunit (FSHB). This induction has been studied here in LbetaT2 gonadotropes using transient expression of ovine FSHBLuc (-4741 bp of ...
Miller William L, Han Sang-oh
doaj   +1 more source

MOLECULAR FACETS OF MITOTIC REGULATION, II. FACTORS UNDERLYING THE REMOVAL OF THYMIDINE KINASE [PDF]

, 1963
Yasou Hotta, Herbert Stern
openalex   +1 more source

Senescence in human AC16 cardiac cells is associated with thymidine kinase induction and histone loss. [PDF]

MicroPubl Biol, 2023
Kastury N, Hidalgo V, Pandi B, Li L, Lam MPY, Lau E.   +5 more
europepmc   +1 more source

Thymidine kinase 1 as a target is regulated by the hsa-let-7b-5p/LINC00665 axis and affects NSCLC prognosis. [PDF]

Heliyon, 2023
Zhu XD, Fan YF, Zhao Y, Song XY, Liu XS, Gao ZJ, Yuan K.   +6 more
europepmc   +1 more source

Thymidine kinase 1 appears to be a marker for the prognosis of hepatocellular carcinoma based on a large-scale, multicenter study. [PDF]

J Cancer Res Clin Oncol, 2023
Jiang Y, Guo L, Han L, Li H, Li C, Wen L, Song Y, Wang Z, Wang P, Guo Q, Zhao W, Liu M, Chen J, Wu Z, Yan Y, Xu K, Gu T, Wu X, He K, Su K, Han Y.   +20 more
europepmc   +1 more source