Results 31 to 40 of about 5,593 (118)

Guanylate Kinase 1 Deficiency: A Novel and Potentially Treatable Mitochondrial DNA Depletion/Deletions Disease

Annals of Neurology, Volume 96, Issue 6, Page 1209-1224, December 2024.
Objective Mitochondrial DNA (mtDNA) depletion/deletions syndrome (MDDS) comprises a group of diseases caused by primary autosomal defects of mtDNA maintenance. Our objective was to study the etiology of MDDS in 4 patients who lack pathogenic variants in known genetic causes.
Agustin Hidalgo‐Gutierrez, Jonathan Shintaku, Javier Ramon, Eliana Barriocanal‐Casado, Alba Pesini, Russell P. Saneto, Gloria Garrabou, Jose Cesar Milisenda, Ana Matas‐Garcia, Laura Gort, Olatz Ugarteburu, Yue Gu, Lahari Koganti, Tian Wang, Saba Tadesse, Megi Meneri, Monica Sciacco, Shuang Wang, Kurenai Tanji, Marshall S. Horwitz, Michael O. Dorschner, Mahesh Mansukhani, Giacomo Pietro Comi, Dario Ronchi, Ramon Marti, Antonia Ribes, Frederic Tort, Michio Hirano   +27 more
wiley   +1 more source

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase [PDF]

British Journal of Cancer, 2010
Potentiation of anticancer activity of capecitabine is required to improve its therapeutic index. In colorectal cancer (CRC) cells, we evaluated whether the histone deacetylase-inhibitor vorinostat may induce synergistic antitumour effects in combination with capecitabine by modulating the expression of thymidine phosphorylase (TP), a key enzyme in the
Di Gennaro E, Piro G, Chianese MI, FRANCO, Renato, Di Cintio A, Moccia T, Luciano A, De Ruggiero I, Bruzzese F, Avallone A, Arra C, Budillon A.   +11 more
openaire   +3 more sources

Serum proteome profiling of plateau acclimatization in men using Olink proteomics approach

Physiological Reports, Volume 12, Issue 24, December 2024.
Abstract Plateau acclimatization involves adaptive changes in the body's neurohumoral regulation and metabolic processes due to hypoxic conditions at high altitudes. This study utilizes Olink targeted proteomics to analyze serum protein expression differences in Han Chinese individuals acclimatized for 6 months–1 year at 4500 and 5300 m altitudes ...
Jingyu Pan, Yue Dong, Zhihao Zou, Tianyan Gu, Ling Chen, Kai Li, Li Wang, Qinghai Shi   +7 more
wiley   +1 more source

Metabolomics‐driven approaches for identifying therapeutic targets in drug discovery

MedComm, Volume 5, Issue 11, November 2024.
Various metabolomics‐based methods were outlined that have been employed for target identification, such as dose–response metabolomics, stable isotope‐resolved metabolomics, mass spectrometry imaging metabolomics. Furthermore, the emerging potentials of target identification based on metabolomics, such as artificial intelligence, single‐cell ...
Shanshan Pan, Luan Yin, Jie Liu, Jie Tong, Zichuan Wang, Jiahui Zhao, Xuesong Liu, Yong Chen, Jing Miao, Yuan Zhou, Su Zeng, Tengfei Xu   +11 more
wiley   +1 more source

A proteomic atlas of glypican‐3 interacting partners: Identification of alpha‐fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer

Proteoglycan Research, Volume 2, Issue 4, October-December 2024.
Abstract Antibody and cell‐based therapeutics targeting cell surface receptors have emerged as a major class of immune therapeutics for treating cancer. However, the number of cell surface targets for cancer immunotherapy remains limited. Glypican‐3 (GPC3) is a cell surface proteoglycan and an oncofetal antigen.
Yi‐Fan Zhang, Shaoli Lin, Zhen Xiao, Mitchell Ho   +3 more
wiley   +1 more source

Biological biomarkers of oral cancer

Periodontology 2000, Volume 96, Issue 1, Page 250-280, October 2024.
Abstract The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant ...
Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo‐Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton‐That, Cun‐Yu Wang, Yvonne L. Kapila   +9 more
wiley   +1 more source

Hyaluronic acid metabolism and chemotherapy resistance: recent advances and therapeutic potential

Molecular Oncology, Volume 18, Issue 9, Page 2087-2106, September 2024.
Hyaluronic acid (HA), a major component of the extracellular matrix, mediates essential biochemical signals required for tissue homeostasis. Many solid tumors are characterized by dysregulated HA metabolism. Here, we review the current knowledge on the role of HA in cancer chemotherapy and examine the status and prospects of HA‐based cancer therapy ...
Zhanhong Liu, Pengbo Hou, Jiankai Fang, Changshun Shao, Yufang Shi, Gerry Melino, Angelo Peschiaroli   +6 more
wiley   +1 more source

Biocatalytic Nucleobase Diversification of 4′‐Thionucleosides and Application of Derived 5‐Ethynyl‐4′‐thiouridine for RNA Synthesis Detection

Angewandte Chemie, Volume 136, Issue 33, August 12, 2024.
A synergistic platform towards 4′‐thionucleosides is presented that enables both biocatalytic nucleobase diversification from 4′‐thiouridine in a one‐pot process and chemical functionalization to access new entities. This approach delivers entry to pyrimidine and purine 4′‐thionucleosides, and chemoenzymatic synthesis provided 5‐ethynyl‐4′‐thiouridine ...
Sarah Westarp, Caecilie M. M. Benckendorff, Jonas Motter, Viola Röhrs, Yogesh S. Sanghvi, Peter Neubauer, Jens Kurreck, Anke Kurreck, Gavin J. Miller   +8 more
wiley   +1 more source

7‐Deazaxanthine, a novel prototype inhibitor of thymidine phosphorylase

FEBS Letters, 1998
7‐Deazaxanthine (7DX) was identified as a novel inhibitor of thymidine (dThd) phosphorylase (TPase). It inhibited the TPase reaction in a concentration‐dependent manner. At 1 mM, it almost completely prevented the TPase‐catalysed hydrolysis of dThd to thymine.
Balzarini, J, Gamboa, A, Esnouf, R, Liekens, S, Neyts, J, De Clercq, E, Camarasa, M, Pérez-Pérez, M   +7 more
openaire   +4 more sources

Dihydropyrimidone Derivatives as Thymidine Phosphorylase Inhibitors: Inhibition Kinetics, Cytotoxicity, and Molecular Docking. [PDF]

Molecules, 2023
Cui TM, Altaf M, Aldarhami A, Bazaid AS, Saeedi NH, Alkayyal AA, Alshabrmi FM, Ali F, Aladhadh M, Khan MY, Alsaiari AA, Ma YR.   +11 more
europepmc   +1 more source