Photoinduced Formation Mechanism of the Thymine–Thymine (6–4) Adduct
The Journal of Physical Chemistry B, 2013 The photoinduced mechanism leading to the formation of the thymine-thymine (6-4) photolesion has been studied by using the CASPT2//CASSCF approach over a dinucleotide model in vacuo. Following light absorption, localization of the excitation on a single thymine leads to fast singlet-triplet crossing that populates the triplet (3)(nπ*) state of thymine.
Angelo Giussani +4 more
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Thymine dissociation and dimer formation: A Raman and synchronous fluorescence spectroscopic study
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Bacteria inactivation by ultraviolet light is caused due to the formation of thymine dimers that inhibit DNA replication. We have used spectroscopic means for the identification of thymine dimer(s) that may pave the way for fast and definite
Anushka Nagpal +5 more
semanticscholar +1 more source
Prebiotic Route to Thymine from Formamide—A Combined Experimental–Theoretical Study
Molecules, 2021 Synthesis of RNA nucleobases from formamide is one of the recurring topics of prebiotic chemistry research. Earlier reports suggest that thymine, the substitute for uracil in DNA, may also be synthesized from formamide in the presence of catalysts ...
Lukáš Petera +12 more
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De novo emergence of adaptive membrane proteins from thymine-rich genomic sequences
Nature Communications, 2020 Recent evidence demonstrates that novel protein-coding genes can arise de novo from non-genic loci. This evolutionary innovation is thought to be facilitated by the pervasive translation of non-genic transcripts, which exposes a reservoir of variable ...
Nikolaos Vakirlis +15 more
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Adenine and Thymine Effect on Quartz Dissolution at Different Artificial Seawaters
Orbital: The Electronic Journal of Chemistry, 2018 According to Bernal (1951) minerals may have played important roles in the origin of life such as: protect biomolecules against degradation by UV radiation or hydrolysis, pre-concentrate biomolecules from prebiotic seas and formation of polymers.
Dimas Augusto Morozin Zaia +2 more
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Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa [PDF]
شیمی کاربردی روز, 2019 In this study, due to the importance of dipeptide compounds in diagnosis of disease or as drug compounds, new dipeptide compounds were synthesized using pyrimidine derivatives of thymine and uracil.
Azam Heidari +3 more
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Investigation of the spin-forbidden process in thymine [PDF]
Hemijska Industrija, 2012 The intersystem crossing rate from the lowest singlet to the lowest triplet state of thymine was studied by means of the ab initio methods. The rate was calculated employing the time-dependent approach based on the correlation function.
Etinski Mihajlo R.
doaj +1 more source
Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells
Molecules, 2023 Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment.
Albina Y. Ziganshina +10 more
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Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells [PDF]
Nucleic Acids Research, 1996 The mutagenic properties of UV-induced photoproducts, both the cis-syn thymine-thymine dimer (TT) and the thymine-thymine pyrimidine pyrimidone (6-4) photoproduct [T(6-4)T] were studied in mammalian cells using shuttle vectors. A shuttle vector able to replicate in both mammalian cells and bacteria was produced in its single-stranded DNA form. A unique
A, Gentil +5 more
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