Results 41 to 50 of about 60,531 (292)
Molecules, 2014 The regioisomeric cycloadducts of bromonitrile oxide and N-benzoyl-2,3-oxaza-norborn-5-ene were easily prepared and elaborated into a novel class of uracil-based scaffolds. The key-synthetic step is the nucleophilic substitution at the sp2 carbon atom of
Misal Giuseppe Memeo +3 more
doaj +1 more source
, 2020 The effects of ionizing radiation on DNA constituents is a widely studied fundamental process using experimental and computational techniques. In particular radiation effects on nucleobases are usually tackled by mass spectrometry in which the nucleobase
Said, Ouaskit +4 more
core +1 more source
Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems
Advanced Materials, EarlyView.DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther +9 more
wiley +1 more source
Incorporation of Thymine into Prototrophic and Thymine-dependent Mutants of Bacillus anthracis [PDF]
Journal of General Microbiology, 1969 SUMMARY: Mutants of Bacillus anthracis which were prototrophic in a defined medium below 32° required either thymidine (mutant thy) or low concentration of thymine (mutant thytlr) for growth at 37°. No thymidylate synthetase was produced by these mutants at 37°. Normal enzyme activity was found in bacteria grown at 25°.
Ivánovics, György +2 more
openaire +3 more sources
Probing the Molecular Frame of Uracil and Thymine with High Harmonic Generation Spectroscopy
, 2020 In this work we present computed high-harmonic generation (HHG) spectra of uracil and thyminemolecules, by means of the real-time time-dependent formulation of Gaussian-based configurationinteraction with single excitations (RT-TD-CIS).
Emanuele, Coccia, Eleonora, Luppi
core +1 more source
Advanced Materials, EarlyView.The intimate interaction between negatively charged RNA molecules and conjugated polymers in organic electrochemical transistors (OECTs) in aqueous electrolytes is investigated. It demonstrates that RNA binding reduces the volumetric capacitance of the polymer channel, enabling the development of an ultrasensitive biosensing platform capable of ...
Hong Liu +7 more
wiley +1 more source
Expression and the Peculiar Enzymatic Behavior of the Trypanosoma cruzi NTH1 DNA Glycosylase. [PDF]
PLoS ONE, 2016 Trypanosoma cruzi, the etiological agent of Chagas' disease, presents three cellular forms (trypomastigotes, epimastigotes and amastigotes), all of which are submitted to oxidative species in its hosts. However, T.
Fernando Ormeño +10 more
doaj +1 more source
Photoinduced Formation Mechanism of the Thymine–Thymine (6–4) Adduct
, 2016 The photoinduced mechanism leading to the formation of the thymine–thymine (6–4) photolesion has been studied by using the CASPT2//CASSCF approach over a dinucleotide model in vacuo.
Angelo Giussani (1753096) +4 more
core +1 more source
Mechanozyme: An Artificial Enzyme With a Mechanophore Framework
Advanced Science, EarlyView.Mechanical destabilization of a G‐quadruplex mechanophore in a DNAzyme markedly boosts its catalytic activity, demonstrating “mechanozymes” as artificial enzymes whose functions are modulated by mechanical stress exerted by ultrasonication. This mechanozyme principle is broadly applicable to control biomolecular activities.
Jiahao Ji +7 more
wiley +1 more source
Molecules, 2022 A DNA Holliday junction (HJ) has been used as a versatile scaffold to create a variety of covalently templated molecular dye aggregates exhibiting strong excitonic coupling. In these dye-DNA constructs, one way to attach dyes to DNA is to tether them via
Shibani Basu +5 more
doaj +1 more source