Results 31 to 40 of about 65,002 (285)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Genetic variations in the human cannabinoid receptor gene are associated with happiness.

PLoS ONE, 2014
Happiness has been viewed as a temporary emotional state (e.g., pleasure) and a relatively stable state of being happy (subjective happiness level).
Masahiro Matsunaga, Tokiko Isowa, Kaori Yamakawa, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Hideki Ohira   +6 more
doaj   +1 more source

Thymine, C5H6N2O2

, 2021
Thymine ...
Shchukarev, Andrey
core   +1 more source

Formation of cyclobutane thymine dimers by tiaprofenic acid and its photoproducts: approach to the photosensitizer triplet state energy limit value [PDF]

RSC Advances, 2015
Cyclobutane thymine dimers, the major photoproducts produced in UV-irradiated DNA, are the main causative agents for mutagenesis and skin cancer. This lesion can also be initiated under UVA radiation, involving triplet–triplet energy transfer mechanism ...
Sandra Michaud, Guillaume Bordeau, Valérie Sartor, Jose Luis Bourdelande, Jordi Hernando, Gonzalo Guirado, Nadia Chouini-Lalanne   +6 more
doaj   +1 more source

Studies on the Two Thymine Residues in the Catalytic Core of 10-23 DNAzyme: The Impact on the Catalysis of Their 5-Substituted Functional Groups

Molecules, 2017
In the 15-mer catalytic core of 10-23 DNAzyme, each residue contributes to the catalytic conformation differently. Here, the critically conserved T4 and the least conserved T8 were modified on their 5-position with hydroxyl, imidazolyl, and amino groups ...
Pengyu Li, Shanshan Du, Yang Li, Junlin He   +3 more
doaj   +1 more source

Platinum(II)–dithiocarbamate complexes with phosphines: Synthesis, characterization and precursor for Pt nanoparticles using ultrasound assisted method [PDF]

E3S Web of Conferences
The reaction between Na2[PtCl4] and thymine bisdithiocarbamate (tdtc) in a 2:1 molar ratio (Metal:Ligand) produced a square planar complex called [Pt(tdtc)2]n (1).
Al-Douri Mawahib Q., Yaseen Asra’a I., Mohammed Modher Y.   +2 more
doaj   +1 more source

1,3-Bis(2-oxopropyl)thymine

IUCrData, 2020
In the title compound [systematic name: 5-methyl-1,3-bis(2-oxopropyl)pyrimidine-2,4(1H,3H)-dione], C11H14N2O4, the two 2-oxopropyl groups are nearly perpendicular to the planar thymine unit. One methyl group of oxopropyl substituent is disordered. In the
Bogdan Doboszewski, Alexander Y. Nazarenko, Fábio da Paixão Soares   +2 more
doaj   +1 more source

Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives

Molecules, 2019
The coupling of 2-bromo-3-benzoyloxycyclobutanone with purine under basic conditions produces two regioisomers consisting of the N-7 and N-9 alkylated products in equal amounts in their racemic forms.
Noha Hasaneen, Abdelaziz Ebead, Muhammad Murtaza Hassan, Hanan Afifi, Howard Hunter, Edward Lee-Ruff, Nadia S. El-Gohary, Azza R. Maarouf, Ali A. El-Emam   +8 more
doaj   +1 more source

Thymine dimers bend DNA. [PDF]

, 1988
A 32-base-pair DNA fragment containing a thymine photodimer was constructed and ligated head-to-tail to obtain multimers of this sequence in which thymine dimers were in phase with the helix screw axis (approximately equal to 3 turns apart). The ligation
Griffith, J., Husain, I., Sancar, A.
core   +1 more source

Low-energy Electron Collisions with Gas-phase Thymine Molecule

Medžiagotyra, 2011
The paper presents an investigation of the negative ion formation of the thymine (T) molecule. The formation of negative ions by electron impact of this molecule is measured.
Irina V. CHERNYSHOVA, Jeno E. KONTROS, Otto B. SHPENIK, Jelena TAMULIENE, Mindaugas L. BALEVICIUS   +4 more
doaj   +1 more source