Mutagenicity of a unique thymine-thymine dimer or thymine-thymine pyrimidine pyrimidone (6-4) photoproduct in mammalian cells [PDF]
Nucleic Acids Research, 1996 The mutagenic properties of UV-induced photoproducts, both the cis-syn thymine-thymine dimer (TT) and the thymine-thymine pyrimidine pyrimidone (6-4) photoproduct [T(6-4)T] were studied in mammalian cells using shuttle vectors. A shuttle vector able to replicate in both mammalian cells and bacteria was produced in its single-stranded DNA form. A unique
A, Gentil +5 more
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Thymine-Modified Nanocarrier for Doxorubicin Delivery in Glioblastoma Cells
Molecules, 2023 Brain tumor glioblastoma is one of the worst types of cancer. The blood–brain barrier prevents drugs from reaching brain cells and shields glioblastoma from treatment.
Albina Y. Ziganshina +10 more
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Prebiotic Route to Thymine from Formamide—A Combined Experimental–Theoretical Study
Molecules, 2021 Synthesis of RNA nucleobases from formamide is one of the recurring topics of prebiotic chemistry research. Earlier reports suggest that thymine, the substitute for uracil in DNA, may also be synthesized from formamide in the presence of catalysts ...
Lukáš Petera +12 more
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Adenine and Thymine Effect on Quartz Dissolution at Different Artificial Seawaters
Orbital: The Electronic Journal of Chemistry, 2018 According to Bernal (1951) minerals may have played important roles in the origin of life such as: protect biomolecules against degradation by UV radiation or hydrolysis, pre-concentrate biomolecules from prebiotic seas and formation of polymers.
Dimas Augusto Morozin Zaia +2 more
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Thymine-Modified Silicones: A Bioinspired Approach to Cross-Linked, Recyclable Silicone Polymers
, 2023 In DNA, thymine typically forms hydrogen bonds with adenine to hold two complementary strands together and to preserve the genetic code. While thymine is typically absent in RNA, a thymine–thymine hydrogen bonding structure is reminiscent of the wobble ...
Paul M. Zelisko +5 more
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Investigation of the spin-forbidden process in thymine [PDF]
Hemijska Industrija, 2012 The intersystem crossing rate from the lowest singlet to the lowest triplet state of thymine was studied by means of the ab initio methods. The rate was calculated employing the time-dependent approach based on the correlation function.
Etinski Mihajlo R.
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, 2022 One-dimensional (1D) supramolecular polymers of aggregation-induced emission (AIE)-active chromophores belong to an in-demand group of functional materials because of their potential applications in optoelectronic devices like optical waveguides, lasers,
Sajena K. Saraswathi +3 more
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Nanomaterials, 2017 Mercury ion (Hg2+) is recognized as one of the most toxic metal ions for the environment and for human health. Techniques utilized in the detection of Hg2+ are an important factor.
Hao Yang +8 more
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Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa [PDF]
شیمی کاربردی روز, 2019 In this study, due to the importance of dipeptide compounds in diagnosis of disease or as drug compounds, new dipeptide compounds were synthesized using pyrimidine derivatives of thymine and uracil.
Azam Heidari +3 more
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A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine [PDF]
, 2014 We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzyme’s active ...
Fox, Keith R. +11 more
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