Results 231 to 240 of about 124,338 (379)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

DNA Triplet Energies by Free Energy Perturbation Theory. [PDF]

J Chem Theory Comput
García-Messeguer R, Navarrete-Miguel M, Martí S, Tuñón I, Roca-Sanjuán D.   +4 more
europepmc   +1 more source

Properties and Assay of Thymine Deoxyribonucleotide Phosphatase of Mammalian Cells in Tissue Culture

, 1965
Per Eker
openalex   +1 more source

Development of Competence in Thymine-starved Bacillus subtilis with Chromosomes Arrested at the Terminus [PDF]

, 1969
L. J. Archer, Otto E. Landman
openalex   +1 more source

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping. [PDF]

Commun Chem
Wen J, Zhang C, Chen X, Dai Z, Li M, Ma W, Yam C, Huang X, Xiong C, Mei H.   +9 more
europepmc   +1 more source

γ-Irradiation of Thymine Dimers in Aqueous Solution

, 1968
R. A. Deering, Wallace Snipes
openalex   +1 more source

A STUDY OF THE MECHANISMS OF DNA AND THYMINE DEGRADATION IN CULTURED HUMAN CELLS INFECTED WITH A LIPOVIRUS [PDF]

, 1962
R. Shihman Chang, H. Liepins
openalex   +1 more source

Recent Advances in Xenes Based FET for Biosensing Applications

Advanced Science, Volume 12, Issue 21, June 5, 2025.
Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang, Chen Wang, Yule Zhang, Ziqian Wang, Yihan Zhu, Yun Wang, Xiangqian Hong, Han Zhang, Ning Fan, Meng Qiu   +9 more
wiley   +1 more source

A DNP‐Supported Solid‐State NMR Approach to Study Nucleic Acids In Situ Reveals Berberine‐Stabilized Hoogsteen Structures in Mitochondria

Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.
Mitochondria are vital for energy production and rely on intricate nucleic acid structures to regulate gene expression. Using DNP‐ssNMR (dynamic nuclear polarization solid‐state NMR), we observed G‐quadruplex formation in intact mitochondria treated with berberine.
Michaela Dzurov Krafčíková, David Beriashvili, Salima Bahri, Menno Bergmeijer, Stuart C. Howes, Andrei Gurinov, Friedrich G. Förster, Gert E. Folkers, Marc Baldus   +8 more
wiley   +2 more sources