Results 231 to 240 of about 56,080 (273)
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Radiation-induced Formation of Thymine-thymine Crosslinks
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1984The formation of dimers upon gamma-irradiation of thymine, thymidine and thymidine-5'-monophosphate in N2O-saturated aqueous solution is reported. A method using capillary gas chromatography-mass spectrometry was developed for their separation and identification.
M, Dizdaroglu, M G, Simic
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Facially-selective thymine thymine photodimerization in TTT triads
Photochemical & Photobiological Sciences, 2012Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3'- and 5'-neighbors. Selective formation of the 3'-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.
Prakash P, Neelakandan +3 more
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Physical Chemistry Chemical Physics, 2006
We discuss the photochemistry and photodissociation dynamics of thymine as revealed by two-colour photofragment Doppler spectroscopy and by one-colour slice imaging. Thymine is optically excited into the pipi* state, known to deactivate quickly.
Michael, Schneider +5 more
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We discuss the photochemistry and photodissociation dynamics of thymine as revealed by two-colour photofragment Doppler spectroscopy and by one-colour slice imaging. Thymine is optically excited into the pipi* state, known to deactivate quickly.
Michael, Schneider +5 more
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Thymine-metal ion interactions: relevance for thymine quartet structures
JBIC Journal of Biological Inorganic Chemistry, 2001Apart from their function as counter ions for the charge neutralization of nucleic acids, alkali metal ions play important roles in stabilizing particular multistranded nucleic acids, e.g. guanine quartets in telomeres and uracil (U) or thymine (T) quartets. Here X-ray crystal structure determinations of a series of alkali metal ions (Na+, K+, Rb+, Cs+)
Freisinger, Eva +2 more
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Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ
Science, 1996The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn
J R, Nelson, C W, Lawrence, D C, Hinkle
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Crystal and Molecular Structure of a Thymine-Thymine Adduct
Science, 1969Thymine-thymine adduct is a product isolated from thymine irradiated with ultraviolet light in frozen aqueous solution. This compound is presumably formed through the rearrangement of an initial photoproduct. Single crystal x-ray diffraction analysis has confirmed the molecular formula of the adduct, 5-hydroxy-6-4′-(5′-methylpyrimid-2′-one ...
I L, Karle, S Y, Wang, A J, Varghese
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2001
More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
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More than 50% of colon cancer-associated mutations in the p53 tumor suppressor gene are C-->T transitions. The majority of them locate in CpG dinucleotides and are thought to have arisen through spontaneous hydrolytic deamination of 5-methylcytosine. This deamination process gives rise to G.T mispairs that need to be repaired to G.C in order to avoid C-
Hardeland, U. +5 more
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Conical Intersections in Thymine
The Journal of Physical Chemistry A, 2006The mechanisms which are responsible for the radiationless deactivation of the npi* and pipi* excited singlet states of thymine have been investigated with multireference ab initio methods (the complete-active-space self-consistent-field (CASSCF) method and second-order perturbation theory with respect to the CASSCF reference (CASPT2)) as well as with ...
Serhiy, Perun +2 more
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Photochemistry of thymine dimers
Journal of Molecular Biology, 1962The extinction coefficient and the quantum yield of photodissociation of a thymine dimer obtained by irradiating thymine in frozen solution have been measured for the range 225 to 289 mμ. The dinucleotides di(thymidine-5′-phosphate) (pTpT), cyclic dithymidylic acid Download : Download full-size image and thymidylyl-(5′−3′)-thymidine ...
H E, JOHNS, S A, RAPAPORT, M, DELBRUECK
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Context-Dependent Photodimerization in Isolated Thymine−Thymine Steps in DNA
Journal of the American Chemical Society, 2008The effect of 280 nm irradiation on a family of synthetic DNA hairpins possessing an alkane linker connecting a six-base pair stem having a single T-T step located at different positions within the hairpin has been investigated. A single adduct assigned to the product of 2+2 dimerization is obtained except in the case of a T-T step located adjacent to ...
Mahesh, Hariharan, Frederick D, Lewis
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