Results 51 to 60 of about 56,080 (273)

A Highly Sensitive and Selective Competition Assay for the Detection of Cysteine Using Mercury-Specific DNA, Hg2+ and Sybr Green I

Sensors, 2011
We here report a rapid, sensitive, selective and label-free fluorescence detection method for cysteine (Cys). The conformation of mercury-specific DNA (MSD) changes from a random coil form to a hairpin structure in the presence of Hg2+ due to the ...
Gang Liu, Lihua Wang, Jingwen Chen, Shuzhen Ren, Dun Pan, Quanwen Liu, Hui Xu, Shuli Gao, Min Ding   +8 more
doaj   +1 more source

Heterogenous Model of Temozolomide Resistance in Glioblastoma Reveals Phenotypic Shifts in Drug Response and Migratory Potential

Advanced NanoBiomed Research, EarlyView.
Glioblastoma mortality is driven by cell invasion and therapeutic resistance. We report a cancer engineering approach to evaluate the behavior of heterogeneous cohorts of temozolomide resistant and responsive GBM cells. We show the effect of physiologically‐relevant metronomic dosing on ensemble drug response and invasion.
Victoria A. Kriuchkovskaia, Ela K. Eames, Sydney A. McKee, Paul J. Hergenrother, Rebecca B. Riggins, Brendan A. C. Harley   +5 more
wiley   +1 more source

Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5‐Aminouracil: A Different Binding Mode from the Anticancer Drug 5‐Fluorouracil [PDF]

, 2022
En‐Shyh Lin, Ren-Hong Luo, Ya‐Ching Yang, Cheng-Yang Huang   +3 more
openalex   +1 more source

Multi-omic analysis of precocious puberty girls: pathway changes and metabolite validation

Frontiers in Endocrinology
ObjectivePrecocious puberty (PP) is a prevalent endocrine disorder affecting the physical and mental wellbeing of children. Identifying the triggering factors of PP has become a central issue.
Fang Zhou, Jianhong Mao, Zhenzhen Jin, Li Zhu, Xiaofang Li   +4 more
doaj   +1 more source

Thymineless Death, at the origin

Frontiers in Microbiology, 2015
Thymineless death (TLD) in bacteria has been a focus of research for decades. Nevertheless, the advances in the last five years, with Escherichia coli as the model organism, have been outstanding.
Elena C Guzmán, Carmen eMartín
doaj   +1 more source

Electrosynthesis of PolyFilm Modified Graphite Electrode and its Application Towards Determination of Thymine [PDF]

Materials Research
This article presents an electrochemical sensor designed for the identification of thymine, one of the nitrogenous bases in deoxyribonucleic acid, crucial for diagnosing damage and health issues such as cancer.
M.P. Amaral, R.S. Babu, L.M. Samyn, A.L.F. de Barros   +3 more
doaj   +1 more source

Nucleobase pairing and photodimerization in a biologically derived metal-organic framework nanoreactor

Nature Communications, 2019
Metal-organic frameworks have shown promise as nanoreactors, facilitating the synthesis of molecules that are otherwise difficult to isolate. Here, the authors design a framework featuring unobstructed adenine linkers to which thymine molecules can base ...
Samantha L. Anderson, Peter G. Boyd, Andrzej Gładysiak, Tu N. Nguyen, Robert G. Palgrave, Dominik Kubicki, Lyndon Emsley, Darren Bradshaw, Matthew J. Rosseinsky, Berend Smit, Kyriakos C. Stylianou   +10 more
doaj   +1 more source

DNA Flap‐Mediated Control of Transcription for Programmable RNA Synthesis

Angewandte Chemie International Edition, EarlyView.
Pyrimidine‐rich ssDNA flaps on the T7 promoter inhibit T7 RNA polymerase (T7RP) transcription. Leveraging this pyrimidine bias, we developed DNAzyme‐ and MNAzyme‐mediated flap promoter induced transcription control (D‐FIT and M‐FIT) systems. These platforms enable regulated transcription and sequence‐specific detection, highlighting the programmable ...
Eun Sung Lee, Jisu Woo, Seokjoon Kim, Seok Hyeon Kim, Gun Haeng Lee, Ki Soo Park   +5 more
wiley   +1 more source

Lack of Association Between Toll-like Receptor 2 Polymorphisms (R753Q and A-16934T) and Atopic Dermatitis in Children from Thrace Region of Turkey

Balkan Medical Journal, 2017
Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can, Mehtap Yazıcıoğlu, Hakan Gürkan, Hilmi Tozkır, Adnan Görgülü, Necdet Hilmi Süt   +5 more
doaj   +1 more source

Isolation of acetylcholinesterase gene from Egyptian Anopheles pharoensis (Theobald)

Journal of Basic and Applied Zoology, 2012
Acetylcholinesterase (ACE) is the target of two major insecticide families, organophosphates (OPS) and carbamates. Acetylcholinesterase is a frequent resistance mechanism in insects and responsible mutations were identified in many dipteran species.
Nahla M. Wassim
doaj   +1 more source