Results 71 to 80 of about 74,896 (329)
Nature Communications, 2019 Metal-organic frameworks have shown promise as nanoreactors, facilitating the synthesis of molecules that are otherwise difficult to isolate. Here, the authors design a framework featuring unobstructed adenine linkers to which thymine molecules can base ...
Samantha L. Anderson +10 more
doaj +1 more source
Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5‐Aminouracil: A Different Binding Mode from the Anticancer Drug 5‐Fluorouracil [PDF]
, 2022 En‐Shyh Lin +3 more
openalex +1 more source
Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate*
Journal of Biological Chemistry, 2014 Background: E3 ubiquitin ligases facilitate destruction of other proteins. Results: In frog egg extract, the DNA repair factor thymine DNA glycosylase (TDG) was destroyed during DNA replication and repair, dependent on the E3 ubiquitin ligase CRL4Cdt2 ...
Tamara J. Slenn +5 more
semanticscholar +1 more source
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
Nature Chemical Biology, 2012 Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a key oxidation product of 5-methylcytosine in a recently discovered cytosine demethylation pathway.
Liang Zhang +8 more
semanticscholar +1 more source
Balkan Medical Journal, 2017 Background: Atopic dermatitis is the most common chronic inflammatory skin disease. A complex interaction of both genetic and environmental factors is thought to contribute to the disease. Aims: To evaluate whether single nucleotide polymorphisms in the
Ceren Can +5 more
doaj +1 more source
Animal Research and One Health, EarlyView.The paper is divided into three main sections: a review of the development of spatial transcriptomics technology, its applications in livestock and poultry research, and its future prospects. This article provides an overview of the current state of spatial transcriptomics in animal research, exploring its integration with multiomics technologies as ...
Mingyu Wang +5 more
wiley +1 more source
Isolation of acetylcholinesterase gene from Egyptian Anopheles pharoensis (Theobald)
Journal of Basic and Applied Zoology, 2012 Acetylcholinesterase (ACE) is the target of two major insecticide families, organophosphates (OPS) and carbamates. Acetylcholinesterase is a frequent resistance mechanism in insects and responsible mutations were identified in many dipteran species.
Nahla M. Wassim
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Joining Nanotubes Comprising Nucleobase-carrying Amphiphilic Polypeptides
CHIMIA, 2018 Three kinds of amphiphilic polypeptides, X-poly(sarcosine)-b-(L-Leu-Aib)6 (X = adenine, thymine, glycolic acid), were synthesized and self-assembled in a tris buffer to take on nanotube morphology.
Toru Itagaki +4 more
doaj +1 more source
Covalent Attachment of a Platinum(II) Complex inside DNA Duplexes
ChemistryEurope, EarlyView.Oxidative addition is used for the site‐specific incorporation of an organometallic PtII complex as an artificial nucleobase into a DNA duplex. The platination stabilizes the duplex and confers it with phosphorescence. An organometallic phosphorescent PtII complex is introduced into DNA duplexes via oxidative addition to a tailor‐made artificial ...
Tim Schäfer +6 more
wiley +1 more source