Results 161 to 170 of about 409,890 (320)

Zebrafish as a Versatile Model Organism: From Tanks to Treatment

MedComm – Future Medicine, Volume 4, Issue 3, September 2025.
The zebrafish, with its optical transparency and genetic tractability, serves as a versatile in vivo platform for biomedical research. This review underscores its significance in modeling a wide spectrum of human diseases—from cancer to metabolic disorders—and in leveraging cutting‐edge technologies like CRISPR and TALENs.
Rupali Srivastava, Kalyani Eswar, Sasvat Sayee Ram Ramesh, Akshit Prajapati, Tanvi Sonpipare, Apoorva Basa, Mounika Gubige, Sribala Ponnapalli, Shashidhar Thatikonda, Aravind Kumar Rengan   +9 more
wiley   +1 more source

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Immune checkpoints in tumor immunotherapy. Ligand binding to the receptor inhibits immune cell function, promotes tumor cell immune escape, and suppresses the immune response. The pathways of action are VISTA‐IGSF11, TIM‐3‐Ceacam1, CD47‐SIRPα, CTLA‐4‐CD80/CD86, PD‐L1‐PD‐1, MHC‐1‐LILRB, and CD24 ‐ Siglec ‐10. There are also other immune checkpoints such
Han Sun, Dan Huang, Huiling Zhang, Mingyuan Dong, Simiao Wang, Man Sun, Jiayi Liu, Yiqi Wang, Xiaojie Qu, Xuefeng Li, Zhaogang Yang   +10 more
wiley   +1 more source

Thymic Microenvironment Remodeling in Cancer Cachexia as a Determinant of Checkpoint Inhibitor Efficacy and Toxicity. [PDF]

J Cachexia Sarcopenia Muscle
Huang RK, Xing YF, Wu XY, Shi ZH, Wei L, Lv XT, Peng LJ, Pang XQ, Yang QT, Li X.   +9 more
europepmc   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

True Thymic Hyperplasia: An Extremely Rare Incidental Finding. [PDF]

Cureus
Salvado de Carvalho I, Baldo MJ.
europepmc   +1 more source

Ruthenium(II)‐Arene Complexes Containing Aryl‐Isatin Schiff Bases and Their Effects on Colon Cancer Cell Lines

Applied Organometallic Chemistry, Volume 39, Issue 8, August 2025.
Aryl‐isatin Schiff base ruthenium (II)‐arene Ru1 complex has (IC50 value of 5.36 ± 1.09) a strong ability to inhibit the growth of SW620 cell line. The intrinsic binding constant Kb of the complex Ru1 was 5.14 × 106 M−1. In absorption spectral study, hyperchromism and hypsochromism were clear indicators that suggested the intercalative type of mode of ...
Aslıhan Karaer Tunçay, Yonca Gungor, Hande Karabıyık, Hulya Ayar Kayali, Hayati Türkmen   +4 more
wiley   +1 more source

Histologic features, growth patterns and classification of atypical thymomas. [PDF]

Mediastinum
Suster DI, Suster S.
europepmc   +1 more source

Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis &Rheumatology, Volume 77, Issue 8, Page 971-980, August 2025.
Objective Rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA‐ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA‐ILD discrimination beyond clinical and genetic ...
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley IV, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +18 more
wiley   +1 more source

Immunodeficiency Diseases and Tumor Immunobiology [PDF]

, 1974
Abramoff, Peter A., Duquesnoy, Rene J.
core   +1 more source

Development and validation of AI-based automatic segmentation and measurement of thymus on chest CT scans. [PDF]

BMC Med Imaging
Guo Y, Gong B, Jiang G, Du W, Dai S, Wan Q, Zhu D, Liu C, Li Y, Sun Q, Fan Q, Liang B, Yang L, Zheng C.   +13 more
europepmc   +1 more source