Results 71 to 80 of about 7,297 (209)

Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?

open access: yesClinical Ophthalmology, 2010
Hooshang Lahooti, Kishan R Parmar, Jack R WallThe Department of Medicine, University of Sydney, Nepean Clinical School, Penrith, NSW, AustraliaAbstract: Thyroid-associated ophthalmopathy (TAO), or thyroid eye disease, is a complex inflammatory disorder ...
Hooshang Lahooti   +2 more
doaj  

Association between copy number variation of complement component C4 and Graves' disease [PDF]

open access: yes, 2011
Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Yu-Huei Liu   +7 more
core   +2 more sources

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

open access: yesAdvanced Science, Volume 12, Issue 45, December 4, 2025.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng   +14 more
wiley   +1 more source

Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatment

open access: yesClinical Ophthalmology, 2008
Kimihito Maeda, Yuichiro Ohara, Masato Hashimoto, Hiroshi OhguroDepartment of Ophthalmology, Sapporo Medical University, School of Medicine, Sapporo, JapanPurpose: To investigate whether serum levels of soluble Fas (sFas) and interleukin-6 (IL-6) could ...
Kimihito Maeda   +3 more
doaj  

Association between G protein polymorphisms (GNAS1 T393C and GNB3 C825T) and course of Graves’ disease and Graves’ orbitopathy [PDF]

open access: yes, 2011
Summary The biology of initiation and progression of Graves’ hyperthyroidism and Graves’ orbitopathy is complex. For the individually tailored therapy of the diseases it is very important to identify the risk factors.
Dmuchowska, Diana
core  

Toll-like receptor gene polymorphisms are associated with susceptibility to graves' ophthalmopathy in Taiwan males [PDF]

open access: yes, 2010
Background Toll-like receptors (TLRs) are a family of pattern-recognition receptors, which plays a role in eliciting innate/adaptive immune responses and developing chronic inflammation. The polymorphisms of TLRs have been associated with the
Wen-Ling Liao   +7 more
core   +2 more sources

Corneal Confocal Microscopy to Diagnose Peripheral Neuropathy: A Systematic Review and Meta‐Analysis

open access: yesEuropean Journal of Neurology, Volume 32, Issue 11, November 2025.
ABSTRACT Background and Objectives Peripheral neuropathy (PN) may be diagnosed late or may remain undiagnosed. Studies have shown that measurement of corneal nerve fiber length (CNFL) using corneal confocal microscopy (CCM) may have diagnostic utility in diabetic and other peripheral neuropathies. Methods The main databases [CENTRAL, Embase (Ovid), and
Ioannis N. Petropoulos   +6 more
wiley   +1 more source

Graves' ophthalmopathy [PDF]

open access: yes, 2009
A 40-year-old woman who recently received a diagnosis of Graves' disease comes for a follow-up visit. She has been taking methimazole, at a dose of 10 mg daily, and is now euthyroid, but for the past 3 months, she has had bothersome eye symptoms ...
Bartalena, Luigi   +1 more
core   +1 more source

Radiological Activity Score (RAS)—MRI Characteristics in Dysthyroid Optic Neuropathy in a Multi‐Ethnic Thyroid Eye Disease Population

open access: yesClinical Endocrinology, Volume 103, Issue 3, Page 385-395, September 2025.
ABSTRACT Purpose Dysthyroid Optic Neuropathy (DON) is a sight threatening and diagnostically challenging complication of Thyroid Eye Disease (TED). We provide a comparative analysis of the MRI features associated between patietnts with and without DON. Methods Anonymised retrospective cohort study of patients with TED over eleven years.
Malik Moledina   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy