Results 51 to 60 of about 5,666,574 (155)

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Absent Bell’s phenomenon in patients with thyroid eye disease

BMC Ophthalmology, 2021
Background To investigate the incidence of absent Bell’s phenomenon (BP) and the relationship between absent BP and inferior rectus muscle hypertrophy and other clinical features in patients with thyroid eye disease (TED). Methods A total of 104 patients
Hyun Woo Chung, Hwa Lee, Sehyun Baek
doaj   +1 more source

The thyrotropin receptor in thyroid eye disease

, 1998
Thyroid eye disease (TED) has an autoimmune etiology, but the nature of the autoantigen that is the target of the initiating event remains unknown. A number of candidates have been proposed based on Western blotting, library screening, and deduction from
Daumerie, Chantal, Ludgate, M, Many, Marie-Christine, Costagliola, S, International Satellite Symposium of the 25th Annual Meeting of the European-Thyroid-Association on Advances in Thyroid Eye Disease, Crisp, M, Weetman, A, Vassart, G., Lane, C   +8 more
core   +1 more source

Clinical Profile of Thyroid Eye Disease and Factors Predictive of Disease Severity in Chennai District of Tamil Nadu

TNOA Journal of Ophthalmic Science and Research
Background: Thyroid eye disease (TED) is a possibly sightthreatening ocular disease generally occurring in the patients diagnosed with hyperthyroidism.
Mohamed Uwais Ulla, Pratheebadevi Nivean, Mohamed Abrar, Nivean Madhivanan   +3 more
doaj   +1 more source

Demographics, Initial Clinical Presentation, and Diagnostic Practices of Thyroid Eye Disease: Insights From a Pilot Survey of Oculoplastic Surgeons

Advances in Public Health, Volume 2026, Issue 1, 2026.
Purpose Thyroid eye disease (TED) is the most common orbital disorder in adults. Its initial clinical manifestations are heterogeneous and may influence early diagnosis and management. However, limited data exist on real‐world perspectives from oculoplastic surgeons who frequently manage patients with TED.
Shiqi Hui, Lihua Luo, Zhijia Hou, Dongmei Li, Weike Zhang   +4 more
wiley   +1 more source

Nanoperlite Particles Enhance Fibrogenesis in Thyroid Orbital Fibroblasts: A Potential Activated Cell Source for Ocular Tissue Engineering

BioMed Research International, Volume 2026, Issue 1, 2026.
Fibroblasts are crucial in tissue engineering because of their ability to synthesize the extracellular matrix (ECM) and secrete growth factors. Orbital fibroblasts (OFs) from patients with thyroid eye disease (TED) exhibit enhanced fibroblastic properties, making them ideal candidates for regenerative medicine in ocular tissue. In the present study, we
Fatemeh Sanie-Jahromi, Razi Sahraeian, Behzad Khademi, Nour El-Gendy   +3 more
wiley   +1 more source

Alemtuzumab‐Induced Graves’ Disease Complicated by Pretibial Myxoedema: A Case Report

Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.
Background Alemtuzumab, a monoclonal antibody targeting CD52, is associated with a high incidence of secondary autoimmune disease, most commonly thyroid dysfunction. Alemtuzumab‐induced Graves’ disease (AIGD) typically follows a relapsing course and may exhibit atypical or severe phenotypes during immune reconstitution (IR). Case Presentation We report
Aongus O’Brolchain, Elham Reda, Kalyani Sen   +2 more
wiley   +1 more source

Unmasking Orbital Myopathy: When Enlarged Extraocular Muscles Indicate More Than Thyroid Eye Disease: Report of Two Cases

Case Reports in Ophthalmological Medicine, Volume 2026, Issue 1, 2026.
Introduction Orbital myopathy is a condition involving the extraocular muscles, and establishment of a differential diagnosis is crucial to determine its etiology. However, the broad spectrum of the etiologies and the overlap in their clinical and radiological findings often make the diagnosis challenging.
Daisuke Shinohara, Muhammad Abumanhal, Yasuhiro Takahashi, Karuna Sharma   +3 more
wiley   +1 more source

Severe Thyroid Eye Disease in the US: A National Perspective

, 2021
Background: Thyroid eye disease (TED) is an unpredictable autoimmune inflammatory disease which can be sight-threatening, debilitating, and disfiguring.
Singh, Gurkirpal, Alabiad, Chris, Mithal, Alka, Sehgal, Maanek, Kossler, Andrea   +4 more
core   +1 more source

Dry eye disease in thyroid eye disease: A narrative review of pathogenic mechanisms and therapeutic implications

Therapeutic Advances in Ophthalmology
Dry eye disease (DED) is a common and persistent manifestation of thyroid eye disease (TED), often remaining symptomatic despite apparent control of orbital inflammation or systemic thyroid dysfunction.
Seyed Mohsen Rafizadeh MD, Enes Eroglu BS, Ali A. Haydar MD, Haniyeh Zeidabadinejad MD, Mostafa Heidari MD, MPH, Mohammad Taher Rajabi MD, Amirhossein Aghajani MD, Ali Davarpanah MD, Kamran Rezaei BS, Mohammad Soleimani MD   +9 more
doaj   +1 more source