Results 41 to 50 of about 179,790 (311)

Thyroid hormone receptors and resistance to thyroid hormone disorders [PDF]

Nature Reviews Endocrinology, 2014
Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal
Tânia M, Ortiga-Carvalho, Aniket R, Sidhaye, Fredric E, Wondisford   +2 more
openaire   +2 more sources

Functional Divergence of Glycoprotein Hormone Receptors [PDF]

, 2010
Two lamprey glycroprotein hormone receptors (lGpH-R I and II) highly similar with gnathostome GpH-Rs were cloned from sea lamprey testes and thyroid, respectively.
Freamat, Mihael, Sower, Stacia A.
core   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Thyroid Functioning in Diabetes Mellitus Complicated with Chronic Renal Disease

Mìžnarodnij Endokrinologìčnij Žurnal, 2013
Thyroid hormones affect renal physiological development, kidney structure, renal hemodynamics, glomerular filtration rate, the function of a number of nephron transport systems, and water-electrolyte metabolism.
Ye.G. Sazonova, T.V. Mokhort
doaj   +1 more source

Thyroid hormone replacement after thyroid lobectomy [PDF]

Surgery, 2009
The purpose of this study was to determine the incidence of and identify risk factors for postoperative hypothyroidism in patients undergoing thyroid lobectomy.We retrospectively reviewed patients who underwent a thyroid lobectomy for benign disease from May 2004 to December 2007.
Samantha J, Stoll, Susan C, Pitt, Jing, Liu, Sarah, Schaefer, Rebecca S, Sippel, Herbert, Chen   +5 more
openaire   +2 more sources

Perubahan Kadar Hormon Tiroid pada Penderita Sindroma Nefrotik [PDF]

, 2008
Thyroid hormones levels in nephrotic syndromeBackground: Nephrotic syndrome is one of the most found kidney disease. A great part (>99%) of circulating thyroid hormones were bound to proteins, thus derangements of blood proteins in nephrotic syndrome are
Asripurwanti, A. (Asripurwanti), Koesnadi, L. (Lydia), Rochmanaji, W. (W), Samad, S. (Samad), Susanto, R. (Rudy)   +4 more
core  

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Measurement of salivary thyroid hormones using the LC-MS/MS technique in a clinical setting

Therapeutic Advances in Endocrinology and Metabolism
Background: Saliva could be an attractive alternative to blood for assessing thyroid hormonal function. Objectives: Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person’s thyroid status and if they ...
Nadia Sawicka-Gutaj, Piotr Glinicki, Kacper Nijakowski, Barbara Bromińska, Magdalena Ostrowska, Alicja Szatko, Zuzanna Sobol, Konrad Kowalski, Paweł Wilk, Wojciech Zgliczyński, Marek Ruchała   +10 more
doaj   +1 more source

Thyroid Disorders and Chronic Kidney Disease

International Journal of Nephrology, 2014
Thyroid hormones play a very important role regulating metabolism, development, protein synthesis, and influencing other hormone functions. The two main hormones produced by the thyroid are triiodothyronine (T3) and thyroxine (T4).
Mohamed Mohamedali, Srikanth Reddy Maddika, Anix Vyas, Viswanathan Iyer, Pramil Cheriyath   +4 more
doaj   +1 more source