THE EFFECTIVENESS OF CLOPIDOGREL AS AN ANTITHROMBOTIC COMPARED TO TICLOPIDINE AND ASPIRIN (META-ANALYSIS) [PDF]
Jurnal Farmasi Sains dan Komunitas, 2017 Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix® was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to ...
Titien Siwi Hartayu, Dewi Setyaningsih
doaj +6 more sources
Ticlopidine and Clopidogrel [PDF]
Circulation, 1999 Abstract —The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition
Martin J. Quinn, Desmond J. Fitzgerald
openaire +3 more sources
Ticlopidine-Induced Cholestatic Inflammatory Hepatitis: New Insights into Pathogenetic Mechanisms of Drug-Related Hepatotoxicity [PDF]
European Journal of Inflammation, 2006 In immune-induced liver damage the reactive metabolites may covalently bind or alter liver proteins such as cytochrome P450 enzymes, which leads to activation of the immune system. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome.
I. Kraslova +5 more
doaj +2 more sources
Determination of ticlopidine in human plasma by capillary gas chromatography with ion trap detection [PDF]
, 2003 A gas chromatographic method for determination of ticlopidine in human plasma using mass spectrometric detection was developed. A Perkin Elmer model 8500 gas chromatograph coupled to an ion trap detector (ITD) in electron impact mode (EI) was used.
Lino, Celeste +2 more
core +3 more sources
Ticlopidine Alone Versus Ticlopidine Plus Aspirin for Preventing Recurrent Stroke
Internal Medicine, 2003 To compare the efficacy and safety of two antiplatelet regimens, ticlopidine alone (200 mg daily) and ticlopidine (100 mg daily) plus aspirin (81 mg daily), in patients with ischemic stroke from the Tokai district of Japan.A randomized comparative study was performed from April 1992 until December 1995, with follow-up for an average of 1.59 years ...
Mitsuyoshi Nakajima +5 more
openaire +5 more sources
Interstitial Pneumonia Induced by Ticlopidine.
Circulation Journal, 2002 A 67-year-old female non-smoker, who had been diagnosed with familial hypercholesterolemia associated with severe atherosclerosis of the coronary, carotid and vertebral arteries, developed interstitial pneumonia 4 months after initiating ticlopidine to inhibit platelet aggregation.
Takeshi Matsuo +11 more
openaire +5 more sources
APLASTIC ANAEMIA AND TICLOPIDINE [PDF]
British Journal of Haematology, 1993 Fernando Sanchez-Gil +3 more
openaire +3 more sources
Ticlopidine and aspirin interactions. [PDF]
Heart, 1997 The risk-benefit balance when aspirin is compared with aspirin combined with ticlopidine is being investigated in several multicentre trials (MUSIC and WEST II versus TASTE, MUST, and STARS respectively). Cardiologists follow one of two strategies. Some prefer a more aggressive antiplatelet regimen, disregarding the risk of neutropenia (0.7%) because ...
Luisa Gregorini, J. Marco
openaire +3 more sources
Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke:Pooled analysis of randomized trials [PDF]
, 2015 Background and Purpose: Lacunar stroke accounts for ≈25% of ischemic stroke, but optimal antiplatelet regimen to prevent stroke recurrence remains unclear.
Benavente, Oscar R. +5 more
core +1 more source
Adherence to secondary stroke prevention strategies - Results from the German stroke data bank [PDF]
, 2003 Only very limited data are available concerning patient adherence to antithrombotic medication intended to prevent a recurrent stroke. Reduced adherence and compliance could significantly influence the effects of any stroke prevention strategies.
Busse, O. +4 more
core +1 more source