Results 11 to 20 of about 8,483 (184)

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper. [PDF]

Allergy
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Cortellini G, Nakonechna A, Barbaud A, Bavbek S, Calogiuri G, Doña I, Kvedariene V, Laguna Martinez JJ, Liberati S, Pagani M, Romano A.   +10 more
europepmc   +2 more sources

Multivariate Adjustments for Average Equivalence Testing. [PDF]

Stat Med
ABSTRACT Multivariate (average) equivalence testing is widely used to assess whether the means of two conditions of interest are “equivalent” for different outcomes simultaneously. In pharmacological research for example, many regulatory agencies require the generic product and its brand‐name counterpart to have equivalent means both for the AUC and ...
Boulaguiem Y, Insolia L, Victoria-Feser MP, Couturier DL, Guerrier S.   +4 more
europepmc   +2 more sources

Comparative Risk of Major Bleeding With Concomitant Use of Oral Anticoagulants and Corticosteroid Bursts. [PDF]

Clin Transl Sci
ABSTRACT The choice of oral anticoagulants and oral corticosteroid (OCS) burst cotherapy may influence the risk of major bleeding; however, this risk remains poorly characterized. We aimed to quantify the comparative safety of non–vitamin K oral anticoagulants (NOACs) versus warfarin on major bleeding while receiving OCS burst cotherapy among patients ...
Yao TC, Chang SM, Tsai YF, Chiang SJ, Tsai HJ.   +4 more
europepmc   +2 more sources

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential. [PDF]

ChemMedChem
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Omar AM, El-Araby ME, Ahmed TA, Donkor AK, Opare A, Ghatge MS, Aljahdali AS, Alhashimi RT, Robinson TN, Balogun B, Macias M, Roland S, Zhang Y, Musayev FN, Abdulmalik O, Safo MK.   +15 more
europepmc   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Effectiveness and Safety of Reduced-Dose Prasugrel in an East Asian Population: PRASFIT-ACS Emulation Using National Health Insurance Claims Data. [PDF]

Clin Pharmacol Ther
Prasugrel is recommended for acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI). However, East Asians exhibit a stronger antiplatelet response, raising concerns about bleeding risks with standard dosing. This retrospective cohort study evaluated the real‐world effectiveness and safety of reduced‐dose prasugrel in
Huang LW, Wu YJ, Lin FJ, Wu CC, Huang HY, Wang CC, Li X.   +6 more
europepmc   +2 more sources

Exposure-Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCM. [PDF]

J Clin Pharmacol
Abstract Mavacamten, a cardiac myosin inhibitor, is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4, and coadministration with strong CYP3A4 or CYP2C19 inhibitors was contraindicated in patients with obstructive hypertrophic cardiomyopathy (HCM) in the US Prescribing Information. This study assessed the safety and efficacy
Merali S, Bunn H, Sychterz C, Chiang M, Puli S, Sehnert AJ, Murthy B, Gobburu J.   +7 more
europepmc   +2 more sources

Repurposing the Antiplatelet Agent Ticlopidine to Counteract the Acute Phase of ER Stress Condition: An Opportunity for Fighting Coronavirus Infections and Cancer

Molecules, 2022
Different pathological conditions, including viral infections and cancer, can have a massive impact on the endoplasmic reticulum (ER), causing severe damage to the cell and exacerbating the disease.
Anna Tesei, Michela Cortesi, Martina Bedeschi, Noemi Marino, Giacomo Rossino, Roberta Listro, Daniela Rossi, Pasquale Linciano, Simona Collina   +8 more
doaj   +1 more source

Sensitive Voltammetric Determination of Ticlopidine in Pharmaceuticals Employing a Multi-Walled Carbon Nanotubes Paste Electrode

Orbital: The Electronic Journal of Chemistry, 2016
A sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE). Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-
Igor Rebech, Jessica Scremin, César Ricardo Teixeira Tarley, Elen Romão Sartori   +3 more
doaj   +3 more sources

Highly productive and scalable approach to synthesize ticlopidine: A potent thienopyridine anti-platelet aggregation drug

Heliyon, 2020
Ticlopidine (trade name Ticlid), an acidic thienopyridine derivative, is an effective, well-known and long-acting inhibitor of platelet aggregation.
Muhammad Faisal, Quret ul Aein, Aamer Saeed, Amara Mumtaz, Fayaz Ali Larik   +4 more
doaj   +1 more source