Results 21 to 30 of about 8,483 (184)

Detecting Adverse Drug Events Through the Chronological Relationship Between the Medication Period and the Presence of Adverse Reactions From Electronic Medical Record Systems: Observational Study

JMIR Medical Informatics, 2021
BackgroundMedicines may cause various adverse reactions. An enormous amount of money and effort is spent investigating adverse drug events (ADEs) in clinical trials and postmarketing surveillance.
Kei Teramoto, Toshihiro Takeda, Naoki Mihara, Yoshie Shimai, Shirou Manabe, Shigeki Kuwata, Hiroshi Kondoh, Yasushi Matsumura   +7 more
doaj   +1 more source

Ticlopidine-Induced Cholestatic Inflammatory Hepatitis: New Insights into Pathogenetic Mechanisms of Drug-Related Hepatotoxicity

European Journal of Inflammation, 2006
In immune-induced liver damage the reactive metabolites may covalently bind or alter liver proteins such as cytochrome P450 enzymes, which leads to activation of the immune system. Ticlopidine is an inhibitor of CYP2C19 human liver cytochrome.
I. Kraslova, L. Muchova, L. Vitek, A. Novotny, T. Svestka, R. Bruha   +5 more
doaj   +1 more source

Agranulocytosis and hepatic toxicity with ticlopidine therapy: a case report

Journal of Medical Case Reports, 2010
Introduction Ticlopidine is a platelet inhibitor used to prevent thrombosis in patients with cerebrovascular or coronary artery disease. The most common side effects are mild and transitory: diarrhea, dyspepsia, nausea and rashes.
Previtera Antonino M, Pagani Rossella
doaj   +1 more source

The effect of antiaggregational therapy on the long-term patency of the femoropopliteal/crural bypass [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2012
Introduction. Antiaggregational therapy can reduce thrombosis development following the arterial reconstruction surgery. In most cases acetylsalicylic acid and ticlopidine are used as antiaggregational agents. Objective.
Vasić Dragan, Radmili Oliver, Davidović Lazar, Vraneš Milica   +3 more
doaj   +1 more source

THE EFFECTIVENESS OF CLOPIDOGREL AS AN ANTITHROMBOTIC COMPARED TO TICLOPIDINE AND ASPIRIN (META-ANALYSIS)

Jurnal Farmasi Sains dan Komunitas, 2017
Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix® was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to ...
Titien Siwi Hartayu, Dewi Setyaningsih
doaj   +1 more source

Study of Factors to Increase the Usage Rate of Generic Drugs in Platelet Aggregation Inhibitors

Inquiry: The Journal of Health Care Organization, Provision, and Financing, 2023
To reduce pharmacy-related medical expenses, it is necessary to reduce drug costs. One way to achieve this is by increasing the usage rate of generic drugs.
Takaaki Suzuki BS, Mari Iwata BS, Mika Maezawa MS, Kiyoka Matsumoto BS, Mizuki Tanaka BS, Riko Satake BS, Misaki Inoue BS, Yu Yoshida BS, Kazuhiro Iguchi PhD, Mitsuhiro Nakamura PhD   +9 more
doaj   +1 more source

Ticlopidine-induced cholestatic hepatitis: A case report and review of the literature

Italian Journal of Medicine, 2012
Introduction Cholestatic hepatitis is frequently a drug-related syndrome. We describe the case of a 57-year-old man who developed cholestatic hepatitis two months after starting therapy with ticlopidine following a carotid endarterectomy.Materials and ...
Luigi Anastasio, Valerio Manno, Maria Carbone, Nicola Lentini, Sandro Baldari, Lucia Sofia, Giuseppe Topa, Antonio Arone   +7 more
doaj   +1 more source

Antiplatelet drugs for secondary prevention in patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis

BMC Neurology, 2021
Background Antiplatelet drugs may prevent recurrent ischemic events after ischemic stroke but their relative effectiveness and harms still need to be clarified.
Cinzia Del Giovane, Giorgio B. Boncoraglio, Lorenza Bertù, Rita Banzi, Irene Tramacere   +4 more
doaj   +1 more source

Safety of Percutaneous Muscle Biopsy: An Update Based on Over 2400 Procedures. [PDF]

Scand J Med Sci Sports
ABSTRACT This study assessed the safety of percutaneous muscle biopsy by analyzing over 2400 procedures performed between 2007 and 2025 in healthy individuals and patients with chronic diseases. We retrospectively reviewed biopsy‐related adverse events among 1246 participants (471 healthy adults and 775 patients) to investigate whether health status or
Santos JVP, Casale AR, Azevedo RA, Politi GBGE, Shinjo SK, Roschel H, Gualano B.   +6 more
europepmc   +2 more sources

Incidence of neutropenia in patients with ticlopidine/Ginkgo biloba extract combination drug for vascular events: A post-marketing cohort study.

PLoS ONE, 2019
Background and purposeThe ticlopidine/Ginkgo biloba ext. combination drug (Yuclid) is used as an antiplatelet agent for prevention of vascular events since its approval in 2008.
Han-Gil Jeong, Jae Sun Yoon, Juneyoung Lee, Hee-Joon Bae   +3 more
doaj   +1 more source