Results 41 to 50 of about 8,106 (209)

ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL?

open access: yesРациональная фармакотерапия в кардиологии, 2016
Mechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are ...
I. A. Latfullin, A. A. Podolskaya
doaj   +1 more source

Do antithrombotic drugs have a role in migraine prevention? A systematic review

open access: yesHeadache: The Journal of Head and Face Pain, Volume 65, Issue 4, Page 709-727, April 2025.
Abstract Objectives To explore the available evidence on the role of antithrombotics as migraine preventive medication. Background In clinical practice, the use of antithrombotic drugs in individuals with migraine is sometimes considered, especially in the case of frequent auras, association with patent foramen ovale, or prothrombotic states.
Federico De Santis   +7 more
wiley   +1 more source

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

open access: yesAdvanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John   +5 more
wiley   +1 more source

Interception and Synthetic Application of Diradical and Diene Forms of Dual‐Nature Azabicyclic o‐Quinodimethanes Generated by 6π‐Azaelectrocyclization

open access: yesAngewandte Chemie, Volume 136, Issue 41, October 7, 2024.
2‐Alkenylarylimines have been shown to undergo 6π‐azaelectrocyclization thermally to generate azabicyclic o‐quinodimethanes. These o‐quinodimethanes show dual nature as a cyclic diene and a benzylic diradical. The interception of the diradicaloid o‐quinodimethanes by H‐atom transfer enabled the synthesis of five tetrahydroisoquinoline alkaloids.
Majji Shankar   +5 more
wiley   +2 more sources

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

open access: yesMicrobiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions.
Selvi C. Ersoy   +9 more
doaj   +1 more source

Pharmacokinetic Profiles of Lansoprazole in Patients With Morbid Obesity Post‐Roux‐en‐Y Gastric Bypass Surgery

open access: yesClinical and Translational Science, Volume 18, Issue 3, March 2025.
ABSTRACT Data on the effects of Roux‐en‐Y gastric bypass (RYGB) surgery on lansoprazole pharmacokinetics in morbidly obese patients are limited. This study aimed to evaluate the impact of RYGB surgery on the pharmacokinetic profile of lansoprazole in Thai morbidly obese patients. Participants received 30 mg of lansoprazole twice daily for 7 days before
Suthep Udomsawaengsup   +9 more
wiley   +1 more source

Drug‐Induced Liver Injury in Patients With Chronic Liver Disease

open access: yesLiver International, Volume 45, Issue 3, March 2025.
ABSTRACT Objective Drug‐induced liver injury (DILI) is a global problem and can develop from exposure to prescription or over‐the‐counter medications as well as herbal and dietary supplements. The diagnosis of DILI is clinically challenging, and liver injury can be severe leading to liver failure, death, or liver transplantation.
Marwan Ghabril   +2 more
wiley   +1 more source

Role of the Extracellular Matrix in Cancer: Insights into Tumor Progression and Therapy

open access: yesAdvanced Therapeutics, Volume 8, Issue 2, February 2025.
The extracellular matrix (ECM) is pivotal in cancer progression, influencing tumor growth, metastasis, and therapy resistance. This paper explores ECM remodeling, highlighting components like collagens and proteoglycans, their impact on immune evasion, and emerging therapies targeting ECM mechanics and composition.
Nimeet Desai   +8 more
wiley   +1 more source

Highly productive and scalable approach to synthesize ticlopidine: A potent thienopyridine anti-platelet aggregation drug

open access: yesHeliyon, 2020
Ticlopidine (trade name Ticlid), an acidic thienopyridine derivative, is an effective, well-known and long-acting inhibitor of platelet aggregation.
Muhammad Faisal   +4 more
doaj  

Antiplatelet combinations for prevention of atherothrombotic events

open access: yesVascular Health and Risk Management, 2011
Mario Bollat,i Fiorenzo Gaita, Matteo AnselminoDepartment of Internal Medicine, Division of Cardiology, University of Torino, ItalyAbstract: Antiplatelet therapy plays a fundamental role in reducing atherothrombotic events by several pathways.
Anselmino M, Bollati M, Gaita F
doaj  

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